A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Cancer Control - December 24, 2023 Category: Cancer & Oncology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research

Development and internal validation of a novel predictive model for SDHB mutations in pheochromocytomas and retroperitoneal paragangliomas
ConclusionsThis study provided a novel and useful tool for predicting SDHB mutations by integrating easily obtained clinical data. It may help clinicians select suitable genetic testing methods and make appropriate clinical decisions for these high-risk patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 21, 2023 Category: Endocrinology Source Type: research