Cancers, Vol. 16, Pages 947: Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes
Cancers, Vol. 16, Pages 947: Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes
Cancers doi: 10.3390/cancers16050947
Authors:
Rana
Koeller
Walker
Unal
Levine
Chittenden
Isidro
Hayes
Manam
Buehler
Manning
Barletta
Hornick
Garber
Ghazani
INT²GRATE Oncology Consortium
Standard methods of variant assessment in hereditary cancer susceptibility genes are limited by the lack of availability of key supporting evidence. In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor progression. We have previously demonstrated the value of integrating tumor and germline findings to comprehensively assess germline variants in hereditary cancer syndromes. Building on this work, herein, we present the development and application of the INT²GRATE|HPPGL platform. INT²GRATE (INTegrated INTerpretation of GeRmline And Tumor gEnomes) is a multi-institution oncology consortium that aims to advance the integrated application of constitutional and tumor data and share the integrated variant information in publicly accessible repositories. The INT²GRATE|HPPGL platform enables automated parsing and integrated assessment of germline, tumor, and genetic findings in hereditary paraganglioma–pheochromocy...
Source: Cancers - Category: Cancer & Oncology Authors: Rana Koeller Walker Unal Levine Chittenden Isidro Hayes Manam Buehler Manning Barletta Hornick Garber Ghazani INT ²GRATE Oncology Consortium Tags: Article Source Type: research