Thiazide diuretics and primary hyperparathyroidism
Br J Hosp Med (Lond). 2023 Dec 2;84(12):1-8. doi: 10.12968/hmed.2023.0228. Epub 2023 Dec 20.ABSTRACTThiazide diuretics exert a natriuretic and diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule. Furthermore, thiazide diuretics affect renal calcium handling by increasing calcium reabsorption, leading to hypocalciuria. The effect that thiazide diuretics exert on parathyroid hormone secretion is controversial. Some studies found parathyroid hormone levels were suppressed with the use of thiazide diuretics, while others found that thiazides were associated with initial parathyroid hormone suppres...
Source: British Journal of Hospital Medicine - December 28, 2023 Category: Internal Medicine Authors: Simon Mifsud Gabriella Montanaro Sarah Craus Emma L Mifsud Mark Gruppetta Source Type: research
Thiazide diuretics and primary hyperparathyroidism
Br J Hosp Med (Lond). 2023 Dec 2;84(12):1-8. doi: 10.12968/hmed.2023.0228. Epub 2023 Dec 20.ABSTRACTThiazide diuretics exert a natriuretic and diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule. Furthermore, thiazide diuretics affect renal calcium handling by increasing calcium reabsorption, leading to hypocalciuria. The effect that thiazide diuretics exert on parathyroid hormone secretion is controversial. Some studies found parathyroid hormone levels were suppressed with the use of thiazide diuretics, while others found that thiazides were associated with initial parathyroid hormone suppres...
Source: British Journal of Hospital Medicine - December 28, 2023 Category: Internal Medicine Authors: Simon Mifsud Gabriella Montanaro Sarah Craus Emma L Mifsud Mark Gruppetta Source Type: research
Thiazide diuretics and primary hyperparathyroidism
Br J Hosp Med (Lond). 2023 Dec 2;84(12):1-8. doi: 10.12968/hmed.2023.0228. Epub 2023 Dec 20.ABSTRACTThiazide diuretics exert a natriuretic and diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule. Furthermore, thiazide diuretics affect renal calcium handling by increasing calcium reabsorption, leading to hypocalciuria. The effect that thiazide diuretics exert on parathyroid hormone secretion is controversial. Some studies found parathyroid hormone levels were suppressed with the use of thiazide diuretics, while others found that thiazides were associated with initial parathyroid hormone suppres...
Source: British Journal of Hospital Medicine - December 28, 2023 Category: Internal Medicine Authors: Simon Mifsud Gabriella Montanaro Sarah Craus Emma L Mifsud Mark Gruppetta Source Type: research
Thiazide diuretics and primary hyperparathyroidism
Br J Hosp Med (Lond). 2023 Dec 2;84(12):1-8. doi: 10.12968/hmed.2023.0228. Epub 2023 Dec 20.ABSTRACTThiazide diuretics exert a natriuretic and diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule. Furthermore, thiazide diuretics affect renal calcium handling by increasing calcium reabsorption, leading to hypocalciuria. The effect that thiazide diuretics exert on parathyroid hormone secretion is controversial. Some studies found parathyroid hormone levels were suppressed with the use of thiazide diuretics, while others found that thiazides were associated with initial parathyroid hormone suppres...
Source: British Journal of Hospital Medicine - December 28, 2023 Category: Internal Medicine Authors: Simon Mifsud Gabriella Montanaro Sarah Craus Emma L Mifsud Mark Gruppetta Source Type: research
A > 50% Intraoperative Parathyroid Hormone Decrease Into Normal Reference Range Predicts Complete Excision of Malignancy in Patients With Parathyroid Carcinoma
The mainstay of successful treatment for parathyroid carcinoma remains complete surgical excision. Although intraoperative parathyroid hormone (ioPTH) monitoring is a useful adjunct during parathyroidectomy for benign primary hyperparathyroidism, its utility for parathyroid carcinoma remains unclear. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - December 27, 2023 Category: Surgery Authors: Valerie L. Armstrong, Tanaz M. Vaghaiwalla, Cima Saghira, Cheng-Bang Chen, Yujie Wang, Johan Anantharaj, Mehmet Ackin, John I. Lew Source Type: research
< em > GCM2 < /em > p.Tyr394Ser variant in Ashkenazi Israeli patients with suspected familial isolated hyperparathyroidism
CONCLUSION: In contrast to previous observations, the GCM2 p.Tyr394Ser variant-associated phenotype may be mild in AJ with FIHP, sometimes mimicking FHH. Because surgery may be curative, surgeons should be aware of the possibility of multiple gland diseases in these patients. The clinical spectrum and clinical utility of screening for this variant warrant further investigation.PMID:38130397 | PMC:PMC10733520 | DOI:10.3389/fendo.2023.1254156 (Source: Atherosclerosis)
Source: Atherosclerosis - December 22, 2023 Category: Cardiology Authors: Auryan Szalat Shoshana Shpitzen Rena Pollack Haggi Mazeh Ronen Durst Vardiella Meiner Source Type: research
Nerve monitoring in endocrine surgery: Practice patterns differ among surgeons for parathyroidectomy and thyroidectomy
It is unknown whether intraoperative nerve monitoring is associated with reduced vocal cord dysfunction after parathyroidectomy. We aimed to investigate intraoperative nerve monitoring use among Collaborative Endocrine Surgery Quality Improvement Program surgeons and factors associated with vocal cord dysfunction after parathyroidectomy. (Source: Surgery)
Source: Surgery - December 21, 2023 Category: Surgery Authors: Patricia C. Conroy, Alexander Wilhelm, Taufiq Rajwani, Michelle Mulder, Jessica Gosnell, Wen T. Shen, Quan-Yang Duh, Sanziana Roman, Julie Ann Sosa Source Type: research
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism
Physiol Res. 2023 Dec 17;72(S4):S357-S363.ABSTRACTMultiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic a...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V čelák Z Šerková K Zaj íčková Source Type: research
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism
Physiol Res. 2023 Dec 17;72(S4):S357-S363.ABSTRACTMultiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic a...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V čelák Z Šerková K Zaj íčková Source Type: research
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism
Physiol Res. 2023 Dec 17;72(S4):S357-S363.ABSTRACTMultiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic a...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V čelák Z Šerková K Zaj íčková Source Type: research
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism
Physiol Res. 2023 Dec 17;72(S4):S357-S363.ABSTRACTMultiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic a...
Source: Physiological Research - December 20, 2023 Category: Physiology Authors: J V čelák Z Šerková K Zaj íčková Source Type: research
GCM2 p.Tyr394Ser variant in Ashkenazi Israeli patients with suspected familial isolated hyperparathyroidism
ConclusionIn contrast to previous observations, the GCM2 p.Tyr394Ser variant-associated phenotype may be mild in AJ with FIHP, sometimes mimicking FHH. Because surgery may be curative, surgeons should be aware of the possibility of multiple gland diseases in these patients. The clinical spectrum and clinical utility of screening for this variant warrant further investigation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 7, 2023 Category: Endocrinology Source Type: research
Performance of [18F]fluorocholine PET/CT in MEN1-related primary hyperparathyroidism before initial surgery or for persistent/recurrent disease
Conclusion[18F]fluorocholine PET/CT is a reliable and robust imaging modality for the evaluation ofMEN1-related pHPT and could guide surgeons in achieving the optimal benefit-risk ratio. This study gives a great impetus for its adoption as a primary diagnostic tool in this context. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 7, 2023 Category: Nuclear Medicine Source Type: research
Performance of [ < sup > 18 < /sup > F]fluorocholine PET/CT in MEN1-related primary hyperparathyroidism before initial surgery or for persistent/recurrent disease
CONCLUSION: [18F]fluorocholine PET/CT is a reliable and robust imaging modality for the evaluation of MEN1-related pHPT and could guide surgeons in achieving the optimal benefit-risk ratio. This study gives a great impetus for its adoption as a primary diagnostic tool in this context.PMID:38057652 | DOI:10.1007/s00259-023-06537-1 (Source: Molecular Medicine)
Source: Molecular Medicine - December 6, 2023 Category: Molecular Biology Authors: Aymeric Boucher Julia Delabie Charlotte Lussey-Lepoutre Magalie Haissaguerre Eric Ouvrard Vija Lavinia Ma ëlle Le Bras Marie Batisse-Lignier Thomas Cuny Nicolas Jacquet-Francillon S ébastien Gaujoux Oc éane Molina Alessio Imperiale Adrien Latge Catheri Source Type: research
