A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
A Rare Reason for Severe Hypocalcemia Following Kidney Transplant: Denosumab Treatment
Exp Clin Transplant. 2024 Jan;22(Suppl 1):342-344. doi: 10.6002/ect.MESOT2023.P10.ABSTRACTDeviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Muride Aktas Hayriye Nur Oray Unlu Murat Karatas Gokalp Okut Berna Eren Adam Uslu Erhan Tatar Source Type: research
Cost-Effectiveness and Clinical Outcomes of Secondary Hyperparathyroidism Treatments in Patients with Chronic Kidney Disease
AbstractThe study addresses the challenge of treating secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, focusing on the cost-effectiveness of surgical versus pharmacological interventions. Conducting a retrospective analysis on 152 CKD patients with SHPT at the Third People's Hospital of Chengdu, the study matched 80 patients into two groups: 40 undergoing parathyroidectomy with autotransplantation (PTX + AT) and 40 treated with calcimimetics. PTX + AT was more effective in alleviating symptoms, particularly bodily pain, and demonstrated greater cost-effectiveness over a long-term peri...
Source: Calcified Tissue International - February 20, 2024 Category: Orthopaedics Source Type: research
Carotid intima-media thickness in surgically or conservatively managed patients with primary hyperparathyroidism
CONCLUSION: Our results suggest that in postmenopausal PHPT patients subclinical atherosclerosis could be halted by PTx, whereas it worsens over time in not operated patients with milder disease.PMID:38345411 | DOI:10.1210/clinem/dgae053 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 12, 2024 Category: Endocrinology Authors: Vincenzo Carnevale Flavia Pugliese Cristina Eller-Vainicher Antonio S Salcuni Luciano Nieddu Iacopo Chiodini Alfredo Scillitani Source Type: research
Improvement of mood and sleep quality in patients with primary hyperparathyroidism after parathyroidectomy: A prospective case-control study
This study aims to assess the negative effects of mood and sleep on patients with primary hyperparathyroidism compared to healthy controls and analyze their improvement after surgery. (Source: Surgery)
Source: Surgery - February 12, 2024 Category: Surgery Authors: Beatriz Febrero, Juan Jos é Ruiz-Manzanera, Inmaculada Ros-Madrid, Adrián Vergara, José M. Rodríguez Source Type: research
Some thoughts on surgery for primary hyperparathyroidism
Parathyroid surgery is an endless exercise of intelligence, enjoyment and … frustration. Even well-trained endocrine surgeons acknowledge that although straightforward parathyroidectomy (PTX) is the rule in, let's say, 90% of the cases, the remaining 10% can be a real challenge, not only from a technical point of view but also from the diagnostic, localization, genetics and postoperative aspects. I am pleased and honored to have been invited to write this introduction editorial and provide the reader with personal insights regarding some of the issues addressed in this comprehensive volume of the AJS on controversies and...
Source: American Journal of Surgery - February 10, 2024 Category: Surgery Authors: Antonio Sitges-Serra Tags: My Thoughts / My Surgical Practice Source Type: research
Which Localizing Strategy is the Most Cost-Effective in Reoperative Primary Hyperparathyroidism?
2%-10% of patients with primary hyperparathyroidism (PHPT) who undergo parathyroidectomy develop persistent/recurrent disease. The aim of this study was to determine which preoperative localization method is most cost-effective in reoperative PHPT. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - February 9, 2024 Category: Surgery Authors: Victor Gazivoda, Katherine M. Prioli, Albert C. Li, Laura Pizzi, Amanda M. Laird, Toni Beninato Tags: Endocrine Surgery Source Type: research
Four-Dimensional Computed Tomography for Parathyroid Adenoma Localization: A Pre-Operative Imaging Protocol
CONCLUSIONS: A 4D CT has impressive rates of accurate localization of parathyroid adenomas; however due to the radiation exposure involved, it should remain a second line imaging modality. PHPT patients should first be evaluated with USG, with 4D CT used if this is unsuccessful and patients are greater than 40 years old, have a high BMI, or are having revision surgery.PMID:38321924 | DOI:10.1177/00034894241230353 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - February 7, 2024 Category: ENT & OMF Authors: Nikhil Bellamkonda Julie Highland Hilary C McCrary Lauren Slattery Brody King Charles Teames Kaylee LeBaron Richard H Wiggins Dev Abraham Jason P Hunt Source Type: research
Modern Trends for Primary Hyperparathyroidism: Intervening on Less Biochemically Severe Disease
Primary hyperparathyroidism (PHPT) is defined by autonomous parathyroid hormone secretion, which has broad physiologic effects. Parathyroidectomy is the only cure and is recommended for patients demonstrating symptomatic disease and/or end organ damage. However, there may be a benefit to intervening before the development of complications. We sought to characterize institutional trends in the biochemical and symptomatic presentation of PHPT and the associated cure and complication rates. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - February 6, 2024 Category: Surgery Authors: Lauren N. Krumeich, Angelica Santos, Douglas L. Fraker, Rachel R. Kelz, Heather Wachtel Tags: Endocrine Surgery Source Type: research
Complications of microwave ablation in patients with persistent/recurrent hyperparathyroidism after surgical or ablative treatment
CONCLUSION: Complication rates for MWA post-surgical or ablative treatments were comparable to initial MWA rates. Most complications were transient, indicating MWA as a viable and safe treatment option for persistent/recurrent HPT patients.PMID:38314664 | DOI:10.1080/02656736.2024.2308063 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 5, 2024 Category: Internal Medicine Authors: Ying Wei Zhen-Long Zhao Jie Wu Shi-Liang Cao Li-Li Peng Yan Li Ming-An Yu Source Type: research
