Enhanced chronic inflammation and increased branched chain amino acids in adrenal disorders: a cross-sectional study
CONCLUSION: Patients with functioning and non-functioning adrenal masses demonstrated increased GlycA and BCAA, biomarkers associated with adverse cardiometabolic disorders and mortality. Patients with NFA demonstrated an adverse metabolic profile similar to patients with MACS and CS.PMID:38546526 | DOI:10.1210/clinem/dgae204 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 28, 2024 Category: Endocrinology Authors: Annop Kittithaworn A Prerna Dogra Jasmine Saini Eke G Gruppen Elizabeth Atkinson Sara Achenbach Kai Yu Karthik Thangamuthu Margery A Connelly Robin Pf Dullaart Irina Bancos Source Type: research
Deteriorated bone microarchitecture caused by sympathetic overstimulation in pheochromocytoma and paraganglioma
ConclusionsPPGL patients had significantly deteriorated bone microarchitecture and strength, especially in the trabecular bone, with an increased bone resorption rate. Our findings provide clinical evidence that sympathetic overstimulation may serve as a secondary cause of osteoporosis, especially in subjects with increased sympathetic activity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 27, 2024 Category: Endocrinology Source Type: research
Large Paraganglioma of the Larynx-Surgical Resection With Laryngeal Framework Preservation
Ear Nose Throat J. 2024 Mar 27:1455613241241961. doi: 10.1177/01455613241241961. Online ahead of print.NO ABSTRACTPMID:38533742 | DOI:10.1177/01455613241241961 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - March 27, 2024 Category: ENT & OMF Authors: Jelena Sotirovi ć Nenad Baleti ć Aleksandar Dimi ć Biserka Vukomanovi ć Đurđević Milanko Milojevi ć Ognjen Čukić Aleksandar Peri ć Source Type: research
Large Paraganglioma of the Larynx-Surgical Resection With Laryngeal Framework Preservation
Ear Nose Throat J. 2024 Mar 27:1455613241241961. doi: 10.1177/01455613241241961. Online ahead of print.NO ABSTRACTPMID:38533742 | DOI:10.1177/01455613241241961 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - March 27, 2024 Category: ENT & OMF Authors: Jelena Sotirovi ć Nenad Baleti ć Aleksandar Dimi ć Biserka Vukomanovi ć Đurđević Milanko Milojevi ć Ognjen Čukić Aleksandar Peri ć Source Type: research
Large Paraganglioma of the Larynx-Surgical Resection With Laryngeal Framework Preservation
Ear Nose Throat J. 2024 Mar 27:1455613241241961. doi: 10.1177/01455613241241961. Online ahead of print.NO ABSTRACTPMID:38533742 | DOI:10.1177/01455613241241961 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - March 27, 2024 Category: ENT & OMF Authors: Jelena Sotirovi ć Nenad Baleti ć Aleksandar Dimi ć Biserka Vukomanovi ć Đurđević Milanko Milojevi ć Ognjen Čukić Aleksandar Peri ć Source Type: research
Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension
DiscussionsOur study indicates cortisol, cortisone, and catecholamine excess are significantly associated with metabolomic variances in EHT versus PHT patients. Notably, catecholamine excess is key to PPGL’s metabolomic changes, whereas in PA, other non-defining adrenal steroids mainly account for metabolomic differences. In CS, cortisol, alongside other non-defining adrenal hormones, contributes to these differences, suggesting that metabolic disorders and cardiovascular morbidity in these conditions could also be affected by various adrenal steroids. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Current prospects of hereditary adrenal tumors: towards better clinical management
AbstractAdrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL) are two rare types of adrenal gland malignancies. Regarding hereditary tumors, some patients with ACC are associated with with Li-Fraumeni syndrome (LFS), and those with PPGL with multiple endocrine neoplasia type 2. Recent studies have expanded this spectrum to include other types of hereditary tumors, such as Lynch syndrome or familial adenomatous polyposis. Individuals harboring germlineTP53 pathogenic variants that cause LFS have heterogeneous phenotypes depending on the respective variant type. As an example, R337H variant found in Brazil...
Source: Hereditary Cancer in Clinical Practice - March 26, 2024 Category: Cancer & Oncology Source Type: research
Constructing a Novel Amino Acid Metabolism Signature: A New Perspective on Pheochromocytoma Diagnosis, Immune Landscape, and Immunotherapy
This study aimed to build a risk model using amino acid metabolism-related genes, enhancing PGPG diagnosis and treatment decisions. We analyzed RNA-sequencing data from the PCPG cohort in the GEO dataset as our training set and validated our findings using the TCGA dataset and an additional clinical cohort. WGCNA and LASSO were utilized to identify hub genes and develop risk prediction models. The single-sample gene set enrichment analysis, MCPCOUNTER, and ESTIMATE algorithm calculated the relationship between amino acid metabolism and immune cell infiltration in PCPG. The TIDE algorithm predicted the immunotherapy efficac...
Source: Biochemical Genetics - March 25, 2024 Category: Genetics & Stem Cells Authors: Zechen Yan Yongkun Luan Yu Wang Yilin Ren Zhiyuan Li Luyang Zhao Linnuo Shen Xiaojie Yang Tonghu Liu Yukui Gao Weibo Sun Source Type: research
Efficacy and Safety of Preoperative Embolization in Glomus Jugulare Tumors: A Systematic Review and Meta-analysis of Clinical Outcomes and Complications
ConclusionThis study suggests that preoperative embolization could decrease surgery duration and blood loss, but emphasizes the importance of evaluating risks like nerve damage. However, the generalizability of these findings is restricted due to the diversity of available data.Graphical Abstract (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - March 25, 2024 Category: Radiology Source Type: research
Management of Pheochromocytomas and Paragangliomas
Pheochromocytomas and paragangliomas are distinctive neuroendocrine tumors which frequently produce excess catecholamines with resultant cardiovascular morbidity. These tumors have a strong genetic component, with up to 40% linked to hereditary pathogenic variants; therefore, germline genetic testing is recommended for all patients. Surgical resection offers the only potential cure in the case of localized disease. Given the potential for catecholaminergic crises, appropriate perioperative management is crucial, and all patients should undergo alpha-adrenergic blockade before resection. Therapeutic options for metastatic d...
Source: Surgical Clinics of North America - March 23, 2024 Category: Surgery Authors: Jesse E. Passman, Heather Wachtel Source Type: research
Interdisciplinary Treatment Of Tumorous And Tumour-Like Lesions Of Peripheral Nerves
Handchir Mikrochir Plast Chir. 2024 Feb;56(1):11-20. doi: 10.1055/a-2250-7772. Epub 2024 Mar 20.ABSTRACTTumorous or tumour-like lesions of peripheral nerves are generally rare, heterogeneous and challenging to diagnose and treat. They may become apparent by a palpable swelling (lump) near nerves, sensory and/or motor deficits, pain to touch or neuropathic pain. In 91% of cases, tumours are benign. The differentiation of entities and their characteristics as well as a function-preserving resection strategy are highly relevant. Misdiagnosis and inadequate treatment can lead to severe deficits and pain syndromes. Benign tumou...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - March 20, 2024 Category: Cosmetic Surgery Authors: Nora Franziska Dengler Maria Teresa Pedro Jonas Kolbenschlag Source Type: research
Contrast-enhanced CT in the differential diagnosis of bladder cancer and paraganglioma
ConclusionThe corticomedullary phase of CECT plays an important role in the preoperative differential diagnosis of BPG and bladder cancer.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - March 19, 2024 Category: Radiology Source Type: research
Stereotactic radiotherapy for head and neck paragangliomas: How long should we wait for treatment response?
CONCLUSION: While SRT demonstrates an excellent LC rate for H&N paragangliomas, it's important to note that the response to treatment may require time. TVR may last beyond the initial year of treatment in a substantial proportion of patients.PMID:38499272 | DOI:10.1016/j.radonc.2024.110232 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 18, 2024 Category: Radiology Authors: Gozde Yazici Alper Kahvecioglu Sezin Yuce Sari Gokhan Ozyigit Demet Yildiz Mustafa Cengiz Source Type: research
Stereotactic radiotherapy for head and neck paragangliomas: How long should we wait for treatment response?
CONCLUSION: While SRT demonstrates an excellent LC rate for H&N paragangliomas, it's important to note that the response to treatment may require time. TVR may last beyond the initial year of treatment in a substantial proportion of patients.PMID:38499272 | DOI:10.1016/j.radonc.2024.110232 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 18, 2024 Category: Radiology Authors: Gozde Yazici Alper Kahvecioglu Sezin Yuce Sari Gokhan Ozyigit Demet Yildiz Mustafa Cengiz Source Type: research
