Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Med Oncol. 2024 Feb 23;41(3):76. doi: 10.1007/s12032-024-02305-9.ABSTRACTAlveolar soft-part sarcoma (ASPS) is a rare soft tissue tumor with a broad morphologic differential diagnosis. While histology and immunohistochemistry can be suggestive, diagnosis often requires exclusion of other entities followed by confirmatory molecular analysis for its characteristic ASPSCR1-TFE3 fusion. Current stain-based biomarkers (such as immunohistochemistry for cathepsin K and TFE3) show relatively high sensitivity but may lack specificity, often showing staining in multiple other entities under diagnostic consideration. Given the discove...
Source: Ann Oncol - February 23, 2024 Category: Cancer & Oncology Authors: Alexander S Taylor Rahul Mannan Liron Pantanowitz Arul M Chinnaiyan Saravana M Dhanasekaran Steven Hrycaj Xuhong Cao May P Chan David Lucas Xiao-Ming Wang Rohit Mehra Source Type: research
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Med Oncol. 2024 Feb 23;41(3):76. doi: 10.1007/s12032-024-02305-9.ABSTRACTAlveolar soft-part sarcoma (ASPS) is a rare soft tissue tumor with a broad morphologic differential diagnosis. While histology and immunohistochemistry can be suggestive, diagnosis often requires exclusion of other entities followed by confirmatory molecular analysis for its characteristic ASPSCR1-TFE3 fusion. Current stain-based biomarkers (such as immunohistochemistry for cathepsin K and TFE3) show relatively high sensitivity but may lack specificity, often showing staining in multiple other entities under diagnostic consideration. Given the discove...
Source: Ann Oncol - February 23, 2024 Category: Cancer & Oncology Authors: Alexander S Taylor Rahul Mannan Liron Pantanowitz Arul M Chinnaiyan Saravana M Dhanasekaran Steven Hrycaj Xuhong Cao May P Chan David Lucas Xiao-Ming Wang Rohit Mehra Source Type: research
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
AbstractAlveolar soft-part sarcoma (ASPS) is a rare soft tissue tumor with a broad morphologic differential diagnosis. While histology and immunohistochemistry can be suggestive, diagnosis often requires exclusion of other entities followed by confirmatory molecular analysis for its characteristicASPSCR1-TFE3 fusion. Current stain-based biomarkers (such as immunohistochemistry for cathepsin K and TFE3) show relatively high sensitivity but may lack specificity, often showing staining in multiple other entities under diagnostic consideration. Given the discovery of RNA in situ hybridization (RNA-ISH) forTRIM63 as a sensitive...
Source: Medical Oncology - February 23, 2024 Category: Cancer & Oncology Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
