Steroid reduction ‐resistant pulmonary involvement with Sweet's syndrome suspected of being vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome: A case report
Few cases of lung lesions presenting with respiratory failure in Sweet's syndrome have been reported. We herein report a case of Sweet's syndrome in a patient suspected with VEXAS syndrome. AbstractIn cases of Sweet's syndrome with pulmonary involvement, fever of unknown origin, and macrocytic anaemia, VEXAS syndrome can be considered in the differential diagnosis. A 67-year-old man who was taking prednisolone for a fever of unknown origin and Sweet's syndrome was referred to us because of an abnormal chest shadow. Computed tomography revealed a nonfibrotic hypersensitivity pneumonitis-like opacity, and blood test results ...
Source: Respirology Case Reports - February 21, 2024 Category: Respiratory Medicine Authors: Yuki Amakusa,
Tatsuro Suzuki,
Masaya Takemura,
Tetsuya Oguri Tags: CASE REPORT Source Type: research
Low-dose methotrexate toxicity leading to pancytopenia: leucovorin as a rescue treatment
Proc (Bayl Univ Med Cent). 2024 Feb 8;37(2):339-343. doi: 10.1080/08998280.2023.2289299. eCollection 2024.ABSTRACTLow-dose methotrexate has several known side effects associated with mild toxicity including nausea, oral ulcers, and anemia. However, it is rare for patients taking low-dose methotrexate to present with symptoms of severe toxicity including pancytopenia, macular punctate rash, and severe stomatitis. Here we present an 83-year-old patient with a history of rheumatoid arthritis on low-dose methotrexate for 1 year presenting with 5 days of worsening facial swelling, oral lesions, and a macular rash to the extremi...
Source: Baylor University Medical Center Proceedings - February 12, 2024 Category: Universities & Medical Training Authors: George Schelzel Anirudh Palicherla Abubakar Tauseef Paul Millner Source Type: research
What is your next step? In a case of hemolysis and pancytopenia
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - February 7, 2024 Category: Emergency Medicine Source Type: research
Aplastic anemia: history and recent developments in diagnosis and treatment
Int J Hematol. 2024 Feb 4. doi: 10.1007/s12185-024-03715-1. Online ahead of print.ABSTRACTAcquired aplastic anemia is an immune-mediated disease that targets hematopoietic stem cells, which is diagnosed by findings of peripheral blood pancytopenia and hypocellular bone marrow. Although the diagnostic definition is simple, differential diagnosis from other overlapping hematopoietic disorders such as hypoplastic myelodysplastic syndrome and inherited bone marrow failure syndrome is not easy. Immune suppressive therapy and allogeneic hematopoietic stem cell transplantation are important treatment approaches for aplastic anemi...
Source: International Journal of Hematology - February 3, 2024 Category: Hematology Authors: Yasushi Onishi Source Type: research
High variability in short and long-term recovery kinetic of blood cell count and blood chemistry in a partial body irradiation mouse model
CONCLUSIONS: Irradiated animals had significant depletion of white blood cells, red blood cells and platelets up to 10 days post-irradiation. Separation between PBI and WBI were observed at 10- and 20-days post-irradiation at which point PBI animals showed sign of recovery while overall cell count remains depleted in WBI animals up to 30 days post-irradiation. In addition, significant changes were found in parameters indicative of hematopoietic injury including hemoglobin count, hematocrit count and white blood cell population. Significant changes were observed in kidney function with changes to blood urea nitrogen and cal...
Source: International Journal of Radiation Biology - February 2, 2024 Category: Radiology Authors: Tien T Tang Janice A Zawaski Omaima M Sabek M Waleed Gaber Source Type: research
Visceral leishmaniasis misdiagnosed as an upper respiratory infection and iron-deficiency anemia in a 20-month-old male patient: a case report
ConclusionBoth in endemic and non-endemic areas the awareness about VL should be increased among the medical professionals. We also recommend that our colleagues take the same approach when dealing with bicytopenia and fever, just as with pancytopenia and fever. The medical community should make sure that none of the cases of fever and pancytopenia are overlooked, especially if we have hepatomegaly and/or splenomegaly. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 31, 2024 Category: General Medicine Source Type: research
Deciphering cytopenias in internal medicine: a single-center observational study
In conclusion, cytopenias in the internal medicine setting are mainly severe, more frequently secondary to associated comorbidities (2/3 of patients) and deserve proper workup before second/third-level tests (immune-hematological assays and CT scan or PET and bone-marrow evalua tion, respectively). (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - January 25, 2024 Category: Emergency Medicine Source Type: research
Upfront umbilical cord blood transplantation versus immunosuppressive therapy for pediatric patients with idiopathic severe aplastic anemia
Acquired severe aplastic anemia (SAA) is a rare, life-threatening disorder characterized by severe progressive pancytopenia mediated by autoimmunity attack on hematopoietic stem and progenitor cells1. The upfront therapy option for SAA is either an allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a human leukocyte antigen (HLA)-matched sibling donor or IST based on the patient's age, comorbidities, and donor availability2. For newly diagnosed children and adolescents with SAA, the standard IST with horse anti-thymocyte globulin (ATG) and cyclosporine (CSA) are often started when an MSD is not available2....
Source: Biology of Blood and Marrow Transplantation - January 24, 2024 Category: Hematology Authors: Xuxu Zhao, Wenxiu Lv, Kaidi Song, Wen Yao, Chun Li, Baolin Tang, Xiang Wan, Liangquan Geng, Guangyu Sun, Ping Qiang, Huilan Liu, Hongjun Liu, Zimin Sun Source Type: research
Pediatric Pancytopenia and Monosomy 7: A Case Report of SAMD9L-Associated Disease
(Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - January 17, 2024 Category: Allergy & Immunology Source Type: research
Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis
Adv Exp Med Biol. 2023;1442:29-44. doi: 10.1007/978-981-99-7471-9_3.ABSTRACTHematopoietic stem cells (HSCs) are adult stem cells with the ability of self-renewal and multilineage differentiation into functional blood cells, thus playing important roles in the homeostasis of hematopoiesis and the immune response. Continuous self-renewal of HSCs offers fresh supplies for the HSC pool, which differentiate into all kinds of mature blood cells, supporting the normal functioning of the entire blood system. Nevertheless, dysregulation of the homeostasis of hematopoiesis is often the cause of many blood diseases. Excessive self-re...
Source: Advances in Experimental Medicine and Biology - January 16, 2024 Category: Research Authors: Hui Wang Yingli Han Pengxu Qian Source Type: research
Caroli disease combined with Banti syndrome in a woman: a case report
In this report, we describe a 29-year-old woman who presented with a >20-year history of hepatitis B surface antigen positivity and a >1-year history of recurrent fatigue and malaise. On examination, the patient had abdominal distension with marked splenomegaly (7 cm below the ribs) and ascites with tenderness of the abdominal muscles to palpation. A complete blood count showed a low white blood cell count, red blood cell count, and hemoglobin concentration. During the course of treatment, the patient developed multiple symptoms of pancytopenia and concomitant splenomegaly, and she was discharged after total splenect...
Source: Cell Research - January 8, 2024 Category: Cytology Authors: Shian Yu Hang Yuan Yong Cao Source Type: research
Graves' disease with pancytopenia: A rare case report
Key Clinical MessageIn this case report we describe a patient with Grave's disease (GD) who was first diagnosed with pancytopenia and did not have any typical symptoms of GD. His hematologic abnormalities were alleviated after treatment with an anti-thyroid drug. Hence, in patients with pancytopenia, GD should also be considered.AbstractA variety of hematologic abnormalities can be seen in Graves' disease (GD), however; here, we describe a patient with GD and a very rare complication; pancytopenia. His hematologic abnormalities and clinical status were alleviated after treatment with an anti-thyroid drug. Hence, in patient...
Source: Clinical Case Reports - January 6, 2024 Category: General Medicine Authors: Neda Meftah,
Sadegh Sedaghat,
Soghra Rabizadeh,
Sara Seifouri,
Khatereh Nasirimeh,
Manouchehr Nakhjavani Tags: CASE REPORT Source Type: research
Numerous gastric nodules in a leukaemia patient
Clinical presentation An 81-year-old white man presented with 2 weeks of odynophagia and dysphagia to solids and liquids limiting his oral intake and leading to 5 lb weight loss. He has a history of chronic myelomonocytic leukaemia with recent transition to myelofibrosis, uncontrolled gastro-oesophageal reflux disease (GORD) and chronic obstructive pulmonary disease on home oxygen. He denied fever, chills, nausea, vomiting, early satiety, abdominal pain, melena or haematemesis. The physical examination was unremarkable, and he had no oral thrush. His laboratory tests showed pancytopenia (absolute neutrophils count 62 cells...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Bahdi, F., Alkassis, S., Lewis, M. S., El-Masry, M., Bejjani, A., Kolb, J. M. Tags: GUT Snapshot, Gut Editor ' s quiz: GI snapshot Source Type: research
