Pancytopenia with aplastic anemia in systemic lupus erythematosus: case series and literature review
We report two cases of SLE patients who presented with pancytopenia, with bone marrow biopsy confirmed AA. One case was treated with cyclophosphamide but unfortunately succumbed to Acute Respiratory Distress Syndrome (ARDS), while the other case was managed with rituximab with a good response. Interestingly, both patients were on azathioprine before the diagnosis of AA. A comprehensive search for reported cases of AA in PubMed, Scopus, and the Directory of Open Access Journals databases was performed to enhance the understanding of the diagnostic and management challenges associated with AA in SLE, facilitating ongoing exp...
Source: Rheumatology International - April 2, 2024 Category: Rheumatology Source Type: research
Early Onset Pancytopenia Post Heart Transplant: Calcineurin Inhibitor-Induced Thrombotic Microangiopathy versus Cytomegalovirus Infection
We report a case study in which a patient was transitioned to belatacept as a result of life-threatening pancytopenia caused by CNIs in the setting of rampant CMV infection. This case emphasizes the importance of a multidisciplinary approach in the management of pancytopenia in heart transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , , J. Herre, A. Yehya Source Type: research
Solid Organ Transplant or Transfusion-Associated Graft-versus-Host Disease in a Lung Transplant Recipient: An Uncertain Culprit with Lethal Complications
Introduction: Solid organ transplant graft-versus-host disease (SOT-GVHD) and transfusion-associated graft-versus-host disease (TA-GVHD) are rare phenomena in which recipients develop GVHD due to the presence of donor lymphocytes within the transplanted organ or transfused blood product. Irradiation of blood products prevents TA-GVHD but also reduces the shelf life of packed red blood cells (pRBCs), delays the release of blood components, and increases costs. Both SOT-GVHD and TA-GVHD can present with an erythematous, maculopapular rash, diarrhea, fever, hepatomegaly, transaminitis, marrow aplasia, and pancytopenia. (Sourc...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Franz, I. Scott, H. Ayyad, K. Gaines, K. McAnally, S. Tokman Source Type: research
Pancytopenia with aplastic anemia in systemic lupus erythematosus: case series and literature review
We report two cases of SLE patients who presented with pancytopenia, with bone marrow biopsy confirmed AA. One case was treated with cyclophosphamide but unfortunately succumbed to Acute Respiratory Distress Syndrome (ARDS), while the other case was managed with rituximab with a good response. Interestingly, both patients were on azathioprine before the diagnosis of AA. A comprehensive search for reported cases of AA in PubMed, Scopus, and the Directory of Open Access Journals databases was performed to enhance the understanding of the diagnostic and management challenges associated with AA in SLE, facilitating ongoing exp...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
A rare case of Fanconi anemia with Mitomycin C sensitivity: A pediatrics case report
Key Clinical MessageFanconi anemia with Mitomycin C sensitivity is a rare, complex hematological condition. Our case study emphasizes the significance of early diagnosis, appropriate genetic testing, and cautious use of chemotherapeutic agents.AbstractFanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure, congenital anomalies, and predisposition to cancer. Here, we present the case of a 6-year-old boy with a known diagnosis of Fanconi anemia who exhibited sensitivity to Mitomycin C. The patient had a history of recurrent blood transfusions due to anemia and was referred to our institution foll...
Source: Clinical Case Reports - March 27, 2024 Category: General Medicine Authors: Vraj Bhatt,
Sunidhi Rohatgi,
Mansi Singh Tags: CASE REPORT Source Type: research
Recurrent venous thrombosis - an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B
S Afr Med J. 2023 Dec 31;114(1):17-21. doi: 10.7196/SAMJ.2024.v114i1.1477.ABSTRACTA 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her rec...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: N Letete D Vaz P H Malishi J J Pogieter P Rheeder Source Type: research
