Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
Mitral valve dysfunction in a woman with newly diagnosed acute promyelocytic leukemia
Clinical introduction A woman in her mid-40s with a recent diagnosis of pulmonary embolism (on rivaroxaban) presented to the emergency room with dyspnea and fatigue. Vital signs were stable on arrival but a new holosystolic murmur was noted on exam and labs revealed pancytopenia. Infectious workup was unrevealing. CT revealed stable pulmonary emboli compared with prior imaging, along with a new splenic infarct. Transthoracic echocardiography (TTE) (figures 1 and 2, ) demonstrated new findings since the patient’s last normal TTE 3 months prior. Following hospital admission, the patient underwent a bone marrow biopsy w...
Source: Heart - March 12, 2024 Category: Cardiology Authors: Bierowski, M. J., Warner, E. D., Edirisuriya, C. D. Tags: Image challenges Source Type: research
Dioscin alleviates aplastic anemia through regulatory T cells promotion
Conclusion: Dioscin markedly attenuated bone marrow failure, and promoted Tregs differentiation, suggesting the maintenance of theimmune balance effect of Dioscin. Dioscin attenuates pancytopenia and bone marrow failure via its Tregs promotion properties.PMID:38466633 | DOI:10.1080/16078454.2024.2326389 (Source: Hematology)
Source: Hematology - March 11, 2024 Category: Hematology Authors: Liwei Fan Runfeng Ni Haijin Wang Le Zhang Aidi Wang Baoshan Liu Source Type: research
Probable secondary hemophagocytic lymphohistiocytosis manifesting as central nervous system lesions after COVID-19 vaccination: a case report
ConclusionTo date, 23 cases of COVID-19 vaccine-related HLH have been reported. Additionally, HLH in COVID-19 patients has been reported in various case reports. To the best of our knowledge, this is the first reported case of central nervous system involvement in HLH related to any type of COVID-19 vaccine. This case suggests that even when there are no systemic symptoms after COVID-19 vaccination, HLH should be considered as a differential diagnosis if brain lesions are suggestive of CNS demyelinating disease. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Case report: A case of novel homozygous LRBA variant induced by chromosomal segmental uniparental disomy - genetic and clinical insights
ConclusionLRBA gene variants can lead to a rare inborn error of immunity disease. The c.2584C>T (p.Gln862Ter) variant in exon 22 of the LRBA gene is a newly identified pathogenic variant, and the homozygous variant caused by uniparental disomy is exceedingly rare. This case represents the second global report of an LRBA gene function loss due to uniparental disomy abnormalities. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 5, 2024 Category: Allergy & Immunology Source Type: research
Pancytopenia following adjuvant therapy with interferon gamma (IFN- γ) in a patient with disseminated nocardiosis
We report a case of pancytopenia following treatment with recombinant interferon gamma (IFN- γ) in a patient with disseminated nocardiosis. A 78-year-old woman presented with non-specific symptoms of general weakness, cough, fever, right-hand paresis, unsteady gait, and vision deterioration. Her medical record revealed multiple allergic reactions, notably to salicylates (including aspirin) , histamines, penicillin, ciprofloxacin, erythromycin, bisoprolol, and iodide. She reported having Henoch–Schönlein purpura, asthma, and arterial hypertension. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2024 Category: Infectious Diseases Authors: Thomas Derungs, Denis Poddubnyy, Thomas Schneider Tags: Case Report Source Type: research
Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis
We report a case of pancytopenia following treatment with recombinant interferon-gamma (IFN- γ) in a patient with disseminated nocardiosis. A 78-year-old woman presented with non-specific symptoms of general weakness, cough, fever, right-hand paresis, unsteady gait, and vision deterioration. Her medical record revealed multiple allergic reactions, notably to salicylates (including aspirin) , histamines, penicillin, ciprofloxacin, erythromycin, bisoprolol, and iodide. She reported having Henoch–Schönlein purpura, asthma, and arterial hypertension. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2024 Category: Infectious Diseases Authors: Thomas Derungs, Denis Poddubnyy, Thomas Schneider Tags: Case Report Source Type: research
Recombinant Human Thrombopoietin Promotes Platelet Engraftment in Severe Aplastic Anemia Patients following Treatment with Haploid Hematopoietic Stem Cell Transplantation using Modified Post-transplantation Cyclophosphamide
Severe aplastic anemia (SAA) is a life-threatening disorder characterized by peripheral blood pancytopenia resulting from bone marrow failure1, 2. Intensive immunosuppressive therapy (IST) and human leukocyte antigen (HLA)-matched sibling donor-hematopoietic stem cell transplantation (MSD-HSCT) are the standard treatment options for SAA. Due to the slow hematopoietic recovery of IST and limited donor sources for MSD-HSCT, HLA-haploidentical-hematopoietic stem cell transplantation (Haplo-HSCT) has become an effective alternative therapy3-5. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - March 3, 2024 Category: Hematology Authors: Andie Fu, Yizhou Peng, Ping Cheng, Jiaying Wu, Xiaojian Zhu, Yang Yang, Lifang Huang, Na Wang, Jue Wang, Jinhuan Xu, Yuling Wan, Yang Cao, Jia Wei, Yi Xiao, Fankai Meng, Hui Cheng, Yicheng Zhang, Donghua Zhang Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research
