Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Myostatin in Muscle Growth, and Efforts to Produce Myostatin-Targeted Therapies
Myostatin is one of the better targets for enhancement therapies from the point of view of feasibility and existing data on its effects. Myostatin suppresses muscle growth via intracellular signaling. A range of possible methods exist to interfere in this process, some of which have been trialed in human patients: reducing production of myostatin, binding to circulating myostatin with antibodies to ensure clearance, preventing myostatin from binding to cell surface receptors in other ways, upregulation of follistatin, an antagonist to myostatin, and so forth. Myostatin loss of function mutants, natural and artificial, exis...
Source: Fight Aging! - April 28, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Are antidepressants also pain relievers?
Did you know that antidepressant medications are often prescribed for people without depression?
It’s true. Antidepressants are frequently prescribed for chronic pain, especially pain related to nerve disease (called neuropathic pain), chronic low back or neck pain, and certain types of arthritis.
In fact, some guidelines for the treatment of chronic low back pain and osteoarthritis (the most common type of arthritis) include antidepressants. One antidepressant in particular, duloxetine (Cymbalta), is FDA-approved for these conditions.
Just how antidepressants reduce pain is not well understood. One possibility is they a...
Source: Harvard Health Blog - April 16, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Back Pain Bones and joints Health Osteoarthritis Pain Management Source Type: blogs
Family and friends matter
I’m going back to my series on behavioural approaches to pain management (it’s a slow process!). For the first two go here and here. Now I want to talk about the impact of family and friends on people living with pain.
The people we live with are so influential on what we do and believe about pain. It’s our parents who first taught us the relationship between the word “pain” and the experience we know as pain. It’s our parents and family who responded when we cried, who kissed it better (or not), who told us to “harden up” (or not), who took us to the doctor (or not), who...
Source: HealthSkills Weblog - April 11, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Back pain Chronic pain Coping strategies Professional topics Science in practice behavioural family pain behaviour spouse Source Type: blogs
Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders.
Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Feedback Loop Between Chronic Inflammation and Pressure Sensing Drives Osteoarthritis
Researchers here present an interesting view of how chronic inflammation affects cartilage tissue to cause the progression of osteoarthritis. A feedback loop is established between mechanisms of inflammation and mechanisms of pressure sensing, leading to the outcome of cartilage degeneration. Novel points of intervention will no doubt arise as the result of this work, with researchers seeking to break the feedback loop. The best approach still appears to be prevention of the chronic inflammation of aging, given the degree to which rising inflammation contributes to myriad age-related conditions.
An unfortunate bio...
Source: Fight Aging! - April 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aquatic treadmill for exercise in the elderly
Aquatic or underwater treadmill exercise is gaining popularity as a means of exercise training in persons with osteoarthritis who cannot exercise on a land treadmill. Water jets opposite to the direction of walking can be used to achieve high ratings of perceived exertion in aquatic treadmill. Water currents in the direction of walking can also support higher speeds if needed, for a morale boost, in those with lower exercise capacity. The advantage of underwater treadmill is that there is no joint impact due to the body weight as occurs with land treadmill.
Both motorised and non motorised versions of aquatic treadmills ...
Source: Cardiophile MD - March 22, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, March 8th 2021
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-a...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pharmacology to Target the Mechanisms of Aging is a Going Concern
Traditional pharmacological drug development involves (a) identifying a protein or protein interaction of interest in the body, (b) screening the small molecule libraries for a compound that affects that target, and then (c) making a better version of that small molecule: more effective, less harmful. That remains the bulk of the medical research and development industry, despite the proliferation of other approaches, including cell therapies, gene therapies, recombinant proteins, monoclonal antibodies, and so forth. There are goals that cannot be achieved by small molecules, and, as techniques improve and costs fall, gene...
Source: Fight Aging! - March 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immun...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Further Evidence for Cellular Senescence to Contribute Meaningfully to the Progression of Diabetic Retinopathy
Ever more of the research community is drawn to work on cellular senescence by the clear, robust, and expanding evidence for senescent cell accumulation to be a major contributing cause of aging. Clearance of senescent cells by senolytic treatments produces extension of healthy life span and rejuvenation in mice, the reversal of many different age-related conditions. Senolytics are presently in the early stages of human clinical trials, with promising results for some of the approaches taken, such as use of the dasatinib and quercetin combination.
The role of senescent cells in the progression of diabetic retinopath...
Source: Fight Aging! - February 15, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Engineered Cartilage Cells Produce Anti-Inflammatory Drugs
Osteoarthritis affects millions of people worldwide, and occurs when the cartilage that protects the ends of bones starts to degrade and wear down. With the aim of ultimately developing treatments for osteoarthritis, researchers from the Washington University School of Medicine in St. Louis have genetically engineered cartilage cells to release an anti-inflammatory drug when they undergo mechanical stress, such as that caused during bending of knees or lifting of heavy loads. Their research is part of a rapidly growing field called mechano-genetics, that studies the effect of physical and mechanical forces on genetic expre...
Source: Medgadget - January 29, 2021 Category: Medical Devices Authors: Rukmani Sridharan Tags: Materials Medicine Orthopedic Surgery Source Type: blogs
Are early detection and treatment always best?
Throughout my medical career, I’ve heard statements like these:
Early detection offers the best chance of cure.
If you wait for symptoms, you’ve waited too long.
Knowledge is power, and the sooner you have the information, the better.
Over time, I’ve realized they are often untrue. Many health conditions go away on their own. In such cases, early testing may amount to wasted effort, time, and medical cost. Some testing is invasive and has a significant risk of complications. And minor abnormalities may lead to more testing. There’s also the anxiety of waiting for results, or learning you have an abnormality of unce...
Source: Harvard Health Blog - January 28, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Back Pain Heart Health Managing your health care Prevention Screening Tests and procedures Source Type: blogs
Sarah ’ s Wheat Belly health and life transformation
Sarah’s story reminds us how the simple matter of diet can shape our lives for decades, affecting energy, body weight, emotional health–just about every aspect of our physical and social lives before we finally stumble on the right answers. After many years of struggling with poor health, relying on prescription medications that never addressed underlying causes, it therefore came as a surprise to Sarah that she could indeed achieve magnificent health without the drugs by simply following the diet programmed into human genetic code and supplementing nutrients that are deficient in modern life.
...
Source: Wheat Belly Blog - January 28, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open grain-free Inflammation joint pain wheat belly Source Type: blogs
Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
