Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Effects of Extracellular Vesicles from Senescent Cells in Osteoarthritis
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Upregulation of YAP or FOXD1 Reduces Cellular Senescence and Osteoarthritis in Mice
Senescent cells are now a prominent target for the development of therapies to treat aging and age-related diseases. Senescent cells accumulate with age, and are responsible for a sizable amount of the chronic inflammation that accompanies old age - as well as fibrosis, compromised regeneration, and a laundry list of other issues. While the dominant approach is selective destruction of these cells, which appears to produce rejuvenation robustly and effectively in mice, a fair number of research groups are interested in finding ways to prevent cells from becoming senescent in the first place. The investigation here into cel...
Source: Fight Aging! - April 9, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CBX4 Upregulation Reduces Cellular Senescence and Osteoarthritis in Mice
Cellular senescence is one of the causes of aging; the inflammatory signals generated by growing numbers of senescent cells disrupt tissue maintenance and cell function, and play an important role in many age-related conditions, including osteoarthritis. The best approach to senescent cells appears to be the simple one: destroy them. They accumulate slowly, and therapies that selectively remove senescent cells have been shown in animal studies to produce significant reversal of numerous aspects of aging. Nonetheless, many research groups are more interested in preventing or modulating senescence, with the open access paper...
Source: Fight Aging! - April 3, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 1st 2019
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults.
Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease
https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/
Cells are equipped with a protein disposal system in the form of the proteas...
Source: Fight Aging! - March 31, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The iovera ° Cryoanalgesia Device: Interview with Tim Still, CEO of Myoscience
Myoscience, a medtech company based in California, has developed the iovera° cryoanalgesia device. The device was FDA cleared in 2013, with an additional clearance in 2017 for knee pain, and uses cryotherapy to freeze peripheral nerves to reduce pain without affecting nearby tissues. The company claims that the device is a useful alternative to opioid therapy for chronic pain.
The iovera° is handheld, and can deliver precise, controlled doses of cryotherapy to specific sensory nerves through a series of needles. The needles create a cold zone around the nerve which is −20°C (-4° F). This causes the myelin sheath and ...
Source: Medgadget - March 28, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Orthopedic Surgery Pain Management Source Type: blogs
Phase II Clinical Trial Results for the Eidos Therapeutics Approach to Transthyretin Amyloidosis
This study represents the first clinical experience with AG10 in the target patient population of transthyretin amyloidosis cardiomyopathy (ATTR-CM). Administration of AG10 was well tolerated and was not associated with safety signals of potential clinical concern. In the present study AG10 treatment increased serum TTR levels from baseline and brought those levels to within the normal range in all subjects, both mutant and wild-type. This included subjects whose baseline levels were markedly below the normal range. The 28-day treatment duration of the present study limits any assessment of clinical benefit.
The ser...
Source: Fight Aging! - March 27, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Placebo Effect, Digested – 10 Amazing Findings
By Christian Jarrett
The placebo effect usually triggers an eye-brow raise or two among even the most hard-nosed of skeptics. We may not be able to forecast the future or move physical objects with our minds, but the placebo effect is nearly as marvellous (Ben Goldacre once called it the “coolest, strangest thing in medicine”).
The term “placebo effect” is short-hand for how our mere beliefs about the effectiveness of an inert treatment or intervention can lead to demonstrable health benefits and cognitive changes – an apparently incontrovertible demonstration of the near-magical power of mind ove...
Source: BPS RESEARCH DIGEST - March 11, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Feature Source Type: blogs
Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Outline of the OncoAge Consortium
The OncoAge consortium is a scientific interest group focused on the overlap between cancer and aging. Like many factions in the broader aging research community, its members are apparently giving cellular senescence a great deal of their attention these days. Better late than never, I'd say, but this focus is arguably less of an example of scrambling to catch up in their case than for purely aging-focused researchers. After all, the cancer research community studied cellular senescence to a significant degree well prior to the 2011 proof of concept study that finally persuaded gerontologists that accumulation of senescenc...
Source: Fight Aging! - March 5, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019
Jim Mellon's Juvenescence venture is at present one of the few major venture organizations focused on approaches to treat aging as a medical condition. Mellon and his colleagues outlined their take on the field in a 2017 book, also called Juvenescence. We are fortunate in that he is among the first few high net worth individuals to both agree with the SENS philosophy of damage repair, and then, much more importantly, follow through in action as well as word. He is not just seeing a massive market opportunity in treating aging, though that is certainly there, but is doing this because he wishes to achieve the goal of radica...
Source: Fight Aging! - March 4, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Is wheat really THAT bad?
Because it has become such a frequent item in everyday meals, suggesting that something so commonplace must be fine, people often ask: Is wheat really that bad?
Let’s therefore catalog the health conditions that are associated with wheat consumption.
Health conditions we know with 100% certainty are caused by consumption of wheat and related grains:
Celiac disease, dermatitis herpetiformis, cerebellar ataxia, “idiopathic” peripheral neuropathy, temporal lobe seizures, gluten encephalopathy, type 1 diabetes, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, tooth decay
Health conditions ...
Source: Wheat Belly Blog - March 2, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune diabetes gluten-free grain-free grains wheat wheat belly Source Type: blogs
Inflammaging and Degenerative Joint Disease
The age-related degeneration of joint cartilage is a strongly inflammatory condition, in which the accumulation of senescent cells plays an important role. Senescent cells produce potent inflammatory signaling that harms the local environment in a range of ways. Systemic inflammation is also thought to be a meaningful contribution to osteoarthritis, however. The immune system becomes dysfunctional throughout the body with age, becoming more active and inflammatory even as it becomes ever less capable of defending against pathogens and errant cells. Minimizing joint issues with aging will no doubt require dealing with both ...
Source: Fight Aging! - February 21, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Goodbye to Compounded Analgesic Creams
This study is one of the largest and best-designed study I ' m aware of of these creams, and the findings are pretty clear: such creams benefit patients via placebo mechanisms, aka they don ' t work.Note that there is a separate body of research on some other topicals which should not be confused with this study. Eg, the 5% lidocaine patch for post-herpetic neuralgia, topical capsaicin for a variety of neuropathies, and at least some topical NSAIDs for osteoarthritis, and topical opioids. I ' m not broadly endorsing those either - it ' s complicated - however they weren ' t tested here and the take home point is we should ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - February 11, 2019 Category: Palliative Care Source Type: blogs
