Patient acceptable symptom state and treatment failure threshold values for work productivity and activity Impairment and EQ-5D-5L in osteoarthritis
ConclusionPASS and TF threshold values for WPAI and EQ-5D-5L might be useful for meaningful interpretation of these measures among people with OA. The observed baseline dependency of estimated thresholds limits their generalizability and values should be applied with great caution in other settings/populations. (Source: Quality of Life Research)
Source: Quality of Life Research - April 25, 2024 Category: Health Management Source Type: research
Cartilage stem/progenitor cells-derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model
In this study, we prepared exosomes (EXOs) from cartilage stem/progenitor cells (CSPCs) and found that treatment with EXOs increased the viability, migration, and proliferation of cultured primary chondrocytes. In a subacute OA rat model, the application of EXOs facilitated cartilage regeneration as evidenced by histological staining. Exosomal protein analysis together with bioinformatics suggested that cyclin-dependent kinase 9 (CDK9) is a key factor for chondrocyte growth and migration. Functional studies confirmed this prediction, that is, inhibiting CDK9 reduced the beneficial effects induced by EXOs in primary chondro...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Jing Chen Xiaohui Ni Jian Yang Hongwei Yang Xiaoyu Liu Minhao Chen Cheng Sun Youhua Wang Source Type: research
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF- κB pathway
CONCLUSIONS: This study demonstrated that CHMP5 repressed IL-1β-induced chondrocyte apoptosis and ECM degradation and blocked NF-κB activation. It was shown that CHMP5 might be a novel potential therapeutic target for OA in the future.PMID:38664616 | DOI:10.1186/s10020-024-00819-6 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Weilu Gao Rui Liu Keke Huang Wenhan Fu Anquan Wang Gongwen Du Hao Tang Li Yin Zongsheng S Yin Source Type: research
Cartilage stem/progenitor cells-derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model
In this study, we prepared exosomes (EXOs) from cartilage stem/progenitor cells (CSPCs) and found that treatment with EXOs increased the viability, migration, and proliferation of cultured primary chondrocytes. In a subacute OA rat model, the application of EXOs facilitated cartilage regeneration as evidenced by histological staining. Exosomal protein analysis together with bioinformatics suggested that cyclin-dependent kinase 9 (CDK9) is a key factor for chondrocyte growth and migration. Functional studies confirmed this prediction, that is, inhibiting CDK9 reduced the beneficial effects induced by EXOs in primary chondro...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jing Chen Xiaohui Ni Jian Yang Hongwei Yang Xiaoyu Liu Minhao Chen Cheng Sun Youhua Wang Source Type: research
Dysplastic Hips That Are Too Late For Periacetabular Osteotomy Are Not Too Early For Total Hip Arthroplasty
Total hip arthroplasty (THA) is often performed in symptomatic patients who have hip dysplasia and do not qualify for periacetabular osteotomy (PAO). The impact of osteoarthritis (OA) severity on postoperative outcomes in dysplasia patients who undergo THA is not well described. We hypothesized that dysplasia patients who have mild OA have slower initial recovery postoperatively, but similar one-year patient-reported outcome measures (PROMs) compared to dysplasia patients who have severe OA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - April 25, 2024 Category: Orthopaedics Authors: Emily A. Treu, Eleanor H. Sato, Olaoluwa Omotowa, Tanner Heaton, Jill A. Erickson, Brenna E. Blackburn, Christopher L. Peters, Lucas A. Anderson Tags: Proceedings of the Hip Society 2023 Source Type: research
Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint
AbstractThe study of neuroimmune crosstalk and the involvement of neurotransmitters in inflammation and bone health has illustrated their significance in joint-related conditions. One important mode of cell-to-cell communication in the synovial fluid (SF) is through extracellular vesicles (EVs) carrying microRNAs (miRNAs). The role of neurotransmitter receptors in the pathogenesis of inflammatory joint diseases, and whether there are specific miRNAs regulating differentially expressed HTR2A, contributing to the inflammatory processes and bone metabolism is unclear. Expression of neurotransmitter receptors and their corre...
Source: Clinical and Experimental Medicine - April 25, 2024 Category: Research Source Type: research
IJERPH, Vol. 21, Pages 539: Home Care for the Elderly: An Integrated Approach to Perception, Quality of Life, and Cognition
This study investigated the impact of home care, health status, and cognition. A qualitative and quantitative approach was employed through a cross-sectional study with a sample of 60 elderly individuals in need of home care in the municipality of Itatiba, São Paulo, Brazil. The analysis utilized the Discourse of the Collective Subject (DCS), EQ-5D, EQ VAS, and Mini-Mental State Examination (MMSE). The sample consisted of 40.0% male and 60.0% female individuals. The majority (61.6%) received weekly visits, mainly from community health agents, who were responsible for the majority of the care (45%). Positive ...
Source: International Journal of Environmental Research and Public Health - April 25, 2024 Category: Environmental Health Authors: Luis Eduardo Genaro Jos é Victor Marconato Elaine Pereira da Silva Tagliaferro Felipe Eduardo Pinotti Aylton Valsecki J únior T ânia Adas Saliba Fernanda Lopez Rosell Tags: Article Source Type: research
Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives
This article explores the heterogeneity observed in clinical studies evaluating OA pain treatments, highlighting the necessity for refined methodologies, personalized patient categorization, and consistent outcome measures. It discusses the role of the multidimensional nature of OA pain, underlying pain mechanisms, and other contributing factors to the heterogeneity in outcome measures. Addressing these variations is crucial to establishing a more consistent framework for evidence-based treatments and advancing care of the patient with OA pain. (Source: Pain and Therapy)
Source: Pain and Therapy - April 25, 2024 Category: Anesthesiology Source Type: research
Post-Traumatic Arthritis of the Knee and Ankle
Post-traumatic osteoarthritis (PTOA) occurs following injury to joints. It accounts for approximately 12% of osteoarthritis and has far-reaching effects on individual patients and social/health care systems. Present work focuses on evaluating the role of the post-traumatic inflammatory response in the development and progression of the disease. As there is minimal evidence to suggest the capacity of cartilage to undergo self-healing, most of this work focuses strictly on the avoidance or prevention of PTOA as opposed to treatment solutions following its onset. Ongoing and future investigations may reveal therapeutic target...
Source: Orthopedic Clinics of North America - April 25, 2024 Category: Orthopaedics Authors: Lucas S. Marchand, Justin M. Haller Source Type: research
Preventing hip osteoarthritis in athletes: is it really a mission impossible?
Hip osteoarthritis (OA) in athletes is important to acknowledge, with early hip OA associated with elite-level high joint impact sports, such as football, ice hockey and handball.1 Current management of hip OA is largely reactive (when OA disease is established and irreversible). Identifying athletes at risk of, or with early-stage hip OA, may improve treatment success and reduce disease burden. Clinicians and researchers need to understand the natural history of OA in active populations, risk factors for early hip OA and whether OA in athletes can be prevented. In this editorial, focussing on elite athletes, we aim to des...
Source: British Journal of Sports Medicine - April 25, 2024 Category: Sports Medicine Authors: Heerey, J. J., van Klij, P., Agricola, R., Dijkstra, H. P., Plass, L., Crossley, K. M., Kemp, J. L. Tags: BJSM Editorial Source Type: research
Policies in Canada fail to address disparities in access to person-centred osteoarthritis care: a content analysis
Women are disproportionately impacted by osteoarthritis (OA) but less likely than men to access OA care, particularly racialized women. One way to reduce inequities is through policies that can influence healt... (Source: BMC Health Services Research)
Source: BMC Health Services Research - April 25, 2024 Category: General Medicine Authors: Angelina Abbaticchio, Madeline Theodorlis, Deborah Marshall, Crystal MacKay, Cornelia M. Borkhoff, Glen Stewart Hazlewood, Marisa Battistella, Aisha Lofters, Vandana Ahluwalia and Anna R. Gagliardi Tags: Research Source Type: research
Risk of Adverse Events Following Total Knee Arthroplasty in Asthma Patients
DISCUSSION: Over one-tenth of patients undergoing TKA were identified as having asthma, and these patients were at greater odds of numerous pulmonary and non-pulmonary adverse events (a trend that increased with asthma severity), as well as 5-year revisions. Clearly, patients with asthma need specific risk mitigation strategies when considering TKA.LEVEL OF EVIDENCE: III.PMID:38657178 | DOI:10.5435/JAAOS-D-23-01142 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 24, 2024 Category: Orthopaedics Authors: Julian Smith-Voudouris Lee E Rubin Jonathan N Grauer Source Type: research
Development of engineered transferosomal gel containing meloxicam for the treatment of osteoarthritis
CONCLUSION: MLX loaded transferosomes containing gel improved the skin penetration and therefore resulted into increased inhibition of TNF-α level.PMID:38657858 | DOI:10.1016/j.pharma.2024.04.006 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 24, 2024 Category: Drugs & Pharmacology Authors: Rahul Maheshwari Mayank Sharma Vijay R Chidrawar Source Type: research
Frozen Shoulder - a short review for the practice
Praxis (Bern 1994). 2024 Mar;113(3):68-73.ABSTRACTThe Frozen Shoulder is a frequently encountered pathology in clinical practice. This condition often coexists with various comorbidities and is characterized by severe pain and a significantly restricted motion of the affected shoulder. A limited passive external rotation with the arm in adduction, with no signs of any other pathology that could explain the finding, such as shoulder osteoarthritis or an undetected posterior dislocation, is pathognomonic. The course of the disease typically spans over one to two years and is usually self-limiting. In the vast majority of cas...
Source: Praxis - April 24, 2024 Category: General Medicine Authors: David Windischbauer Karim Eid Source Type: research
Risk of Adverse Events Following Total Knee Arthroplasty in Asthma Patients
DISCUSSION: Over one-tenth of patients undergoing TKA were identified as having asthma, and these patients were at greater odds of numerous pulmonary and non-pulmonary adverse events (a trend that increased with asthma severity), as well as 5-year revisions. Clearly, patients with asthma need specific risk mitigation strategies when considering TKA.LEVEL OF EVIDENCE: III.PMID:38657178 | DOI:10.5435/JAAOS-D-23-01142 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 24, 2024 Category: Orthopaedics Authors: Julian Smith-Voudouris Lee E Rubin Jonathan N Grauer Source Type: research
