B2M as a Surface Marker of Cellular Senescence
Before the advent of the first senolytic drugs capable of selectively destroying senescent cells, it was thought by many that progress towards producing rejuvenation in the old via the safe elimination of senescent cells from the body would require the identification of surface markers that are distinctive to the state of senescence. Given a surface marker that clearly and distinctively identifies a cell population, a broad range of strategies become available for the development of targeted therapies. As it turned out,, however, the first senolytics took advantage of the peculiarities of the internal state of senescent ce...
Source: Fight Aging! - October 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gene Therapies Make Compensatory Metabolic Adjustment More Precise, But That Still Isn't Damage Repair
Given a suitable delivery system, one that localizes to the desired target tissues to a far greater degree than to all other undesirable off-target tissues, the big advantage of a gene therapy is it precisely achieves the manipulation desired. It dials up or dials down expression for selected genes, alters the amount of proteins produced from those genes, and thereby changes cell behavior as a consequence - and that is all it does. One doesn't have the endless concern about off-target effects that characterize small molecule drug development.
There are, of course, different challenges. Setting aside some adventurous...
Source: Fight Aging! - October 13, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 11th 2021
In conclusion, this study examined how age and the process of aging are associated with changes in the microbiome of the small intestine, using validated sampling and processing techniques. The most significant differences are higher relative abundance of the phylum Proteobacteria and decreased relative abundance of Bacteroidetes in older subjects when compared to the youngest group. The higher relative abundance of Proteobacteria appeared to affect other duodenal microbial taxa, leading to decreased microbial diversity and increased relative abundance of coliforms and of anaerobic bacteria. The small intestine is vital to...
Source: Fight Aging! - October 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Mesenchymal Cells Cause Localized Inflammation in Osteoarthritic Cartilage
Given the failure of a locally injected senolytic drug to make a meaningful impact in osteoarthritis, the present consensus at the senolytics end of the longevity industry appears to be that systemic inflammatory signalling from senescent cells elsewhere in the body outweighs the contribution of local senescent cells in osteoarthritic joints. But perhaps the senolytic drug used in the failed trial was not a good candidate for humans; it remains to be seen as to whether better outcomes can be produced by systemic senolytic approaches in clinical trials for osteoarthritis. Meanwhile, researchers here suggest that there is in...
Source: Fight Aging! - October 8, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pain – or pain-related disability?
I’m struck at how often clinicians focus on pain intensity when how much pain intrudes on life matters more. I wonder whether new therapists might not have read some of the old studies looking at the relationship between pain intensity and disability – because while there is a relationship there, it’s not nearly as strong as we might think.
Let’s define a couple of terms first: pain is, I think most of us can agree, “an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage”. (click for full definition and not...
Source: HealthSkills Weblog - October 3, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, September 6th 2021
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity.
Building a Therapy for Aging Based on SIRT6 Upregulation
https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/
G...
Source: Fight Aging! - September 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
miR-455 is Protective in Osteoarthritis
MicroRNAs are involved in the regulation of gene expression, increasing or decreasing the production of proteins for specific genes, and thereby changing cell behavior. Researchers here find a microRNA that acts to reduce cartilage degeneration in osteoarthritis. Levels are reduced in human osteoarthritic cartilage, and delivering this microRNA as a therapy reduces the level of pathology in a mouse model of injury-induced osteoarthritis. The delivery of manufactured microRNA, intended to alter cell behavior in advantageous ways, is a growing area of development. There is enough industry support to encourage more basic rese...
Source: Fight Aging! - September 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
3D-Printed Implant for Personalized Knee Realignments
Researchers at the University of Bath in the UK created a framework for 3D printing personalized high-tibial osteotomy (HTO) plates, using a titanium alloy, for knee realignments in osteoarthritis patients. The plates should fit nearly perfectly when implanted thanks to the new approach. The researchers have also developed an improved surgical technique, the TOKA (Tailored Osteotomy for Knee Alignment), which they claim should improve the fit of the HTO on the knee and significantly speed up HTO surgery from two hours to approximately 30 minutes.
“Knee osteoarthritis is a major health, social and economic issue an...
Source: Medgadget - August 9, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelial Cell Senescence Accelerates Atherosclerosis
Atherosclerosis, a condition in which fatty lesions form to narrow, weaken, and distort blood vessel walls, might be primarily thought of as a condition of macrophage dysfunction. The innate immune cells called macrophages are responsible for clearing out unwanted lipids from blood vessel walls. Unfortunately, the growing prevalence of oxidized lipids and an inflammatory environment arising in later life causes macrophages to falter at this task. Macrophages become inflammatory rather than helpful in the lesion environment, then are overwhelmed and die, but are still attracted in ever greater numbers to swell the size of t...
Source: Fight Aging! - July 26, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 28th 2021
In conclusion, in our prospective community-based study, aging-related biomarkers were associated with measures of subclinical atherosclerosis cross-sectionally and with all-cause mortality prospectively, supporting the concept that these biomarkers may reflect the aging process in community-dwelling adults.
The Role of Aging Macrophages in Skin Inflammation
https://www.fightaging.org/archives/2021/06/the-role-of-aging-macrophages-in-skin-inflammation/
The immune system is complex and ages in complex ways, pressed by the lifetime burden of infection and rising levels of molecular damage that trigger man...
Source: Fight Aging! - June 27, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senolytic Therapy Alleviates Temporomandibular Joint Degeneration in Old Mice
Senescent cell accumulation appears to be a major player in the pathology of most of the joint-related issues that occur in older individuals. Senescent cells secrete signals that provoke a state of chronic inflammation, alter nearby cell behavior, and disrupt tissue structure and maintenance. Clearance of these cells reverses numerous age-related conditions and measures of aging in mice. Hence the advent of senolytic therapies that selectively destroy senescent cells is a much anticipated development in medicine. Indeed, the first such therapies are pre-existing drugs, such as the dasatinib and quercetin combination, are ...
Source: Fight Aging! - June 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
5 Out Of The Ordinary Ways Yoga Keeps You Fit
Yoga does feel good; there’s no doubt about it. But the best thing is, it doesn’t only feel good but has tons of health benefits.
From building stamina to dealing with stress and depression, yoga can be the best friend to save your day.
If you haven’t tried yoga yet, you’re missing out on something really interesting.
The article contains 5 out of the ordinary ways yoga keeps you fit.
Let’s get off the ground:
1. Yoga Releases Stress
Not many people know about it, but yoga can release stress by promoting relaxation.
As far as scientific studies are concerned, yoga decreases cortisol sec...
Source: PickTheBrain | Motivation and Self Improvement - June 15, 2021 Category: Consumer Health News Authors: Heather Clinton Tags: featured health and fitness self-improvement mental health yoga Source Type: blogs
Coxarthrosis
Time goes by so quickly that I can’t keep up. So much to do around the house (etc.), the cats (etc)…etc.
And then…Coxarthrosis came into my life…
The pain began months ago…I don’t remember exactly when, but I recently found an October 2020 text message sent to a friend in which I wrote that I had some pain in my hip and unfortunately had to postpone our rendezvous. So something was clearly happening as many as seven (!) months ago. Back then, though, Stefano and I both thought it was just a pulled muscle or something minor that would heal itself in time…
I began paying ...
Source: Margaret's Corner - May 22, 2021 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
