Cartilage on a Chip to Identify New Treatments for Osteoarthritis
Researchers
from the Polytechnic University of Milan and the University Hospital of Basel
have developed a microfluidic chip containing cartilage, which can be subjected
to mechanical stress. The procedure mimics the conditions of osteoarthritis and
could help in developing new treatments.
Osteoarthritis
is relatively common among people over 60, with 20% of women and 10% of men suffering
its effects at this age. However, perhaps surprisingly, there are no drugs available
that can halt or reverse the process, with palliative care or surgery
frequently being the only options available.
Experimental
models that accur...
Source: Medgadget - August 27, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Geriatrics Medicine Orthopedic Surgery Source Type: blogs
Importance of Yoga: Yoga for Physical and Mental Health
You're reading Importance of Yoga: Yoga for Physical and Mental Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Yoga has multi-faceted definitions and terms associated with it and mainly focuses on, strength, and flexibility of the human body to keep it sound and healthy. For the wellness of our mental and physical growth and strength, Yoga has been practiced for ages. Originated in India, this technique has a bright history of over five thousand years. The exercises include a series of stretches and postures...
Source: PickTheBrain | Motivation and Self Improvement - August 12, 2019 Category: Consumer Health News Authors: UttamGhosh Tags: featured health and fitness psychology self improvement mental health stress yoga yoga benefits Source Type: blogs
Are Radiologists Prepared for The Future?
This article originally appeared on Medium here. (Source: The Health Care Blog)
Source: The Health Care Blog - August 9, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Technology Medical Practice Physicians AI Alex Logsdon Artificial intelligence Radiology Source Type: blogs
DGCR8 Overexpression Attenuates the Accumulation of Senescent Cells with Age
Given the newfound acceptance of cellular senescence as an important cause of aging, many more research groups are assessing the impact of senescent cells in their research into aging. Here, the focus is on chromatin organization, a collection of nuclear structures and processes in the cell that appear to have some influence over the pace of aging over a lifetime. The researchers discover that the gene DGCR8 accelerates the appearance of senescent cells and dysfunction when mutated, and thus producing broken protein machinery, but slows the accumulation of lingering senescent cells when overexpressed in its correct form. T...
Source: Fight Aging! - August 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 5th 2019
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - August 4, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
UNITY Biotechnology Scheduling Phase II Senolytics Trial for Late 2019
In this study, UBX0101 was well-tolerated. Improvement in several clinical outcomes, including pain and function, as well as modulation of certain senescence-associated secretory phenotype (SASP) factors and disease-related biomarkers was observed after a single dose of UBX0101.
UNITY plans to initiate a Phase 2 study of UBX0101 in patients with painful, moderate-to-severe OA of the knee. The study is expected to enroll approximately 180 patients with initiation expected in the fourth quarter of 2019 and initial 12-week results expected in the second half of 2020. This will be a randomized, double-blind, placebo-con...
Source: Fight Aging! - August 1, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fibrates as a Potential Class of Senolytic Therapy to Clear Senescent Cells
Accumulation of senescent cells with age is one of the causes of aging. In recent years, the broader scientific community has become convinced of this point, and thus funding is now directed towards many varied investigations of cellular senescence and what to do about it. A young industry has emerged, made up of biotech companies focused on the selective destruction of senescent cells, mostly using small molecule drugs. Since these drugs operate through different mechanisms, tend to be tissue specific, only clear a fraction of senescent cells that varies by tissue, and will thus probably be more effective when combined to...
Source: Fight Aging! - July 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Mainstream View of the Longevity Industry
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - July 17, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Physician Letter Essay Sample
You're reading A Physician Letter Essay Sample, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
From: Dr. Abu Salim Idris (Consultant Neurologist at KPJ Tawakkal
Hospital/ MMC NO 23250 / nsr 124687/)
To: Whom it may concern
I Am writing regarding the health of
my patient, name: MOHAMED YAHYA RASHEED AL JUMA,
Passport NO: VP3153200 (OMAN), D.O.B: 01/07/1991
The above-mentioned patient was born on the 1st day of July 1991 in Oman
and a student at the KDU University in Malaysia. The student is set to go back
for hi...
Source: PickTheBrain | Motivation and Self Improvement - July 12, 2019 Category: Consumer Health News Authors: elan peter Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, July 1st 2019
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - June 30, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rejuvenation Biotechnology Companies Presenting at Biotech Investing in Longevity, in San Francisco May 2019
Aikora Health and Foresight Institute recently collaborated to host a gathering of investors, entrepreneurs, and supporters from the core rejuvenation biotechnology community. The event was held in San Francisco, and I attended to present a summary of ongoing work at Repair Biotechnologies. It was an interesting mix of local folk and visitors from across the US, a chance to catch up with fellow travelers from other companies and some of our investors. As you probably know, the SENS Research Foundation and a number of influential aging research institutions, such as the Buck Institute, are based in the Bay Area. It has long...
Source: Fight Aging! - June 27, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age.
Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
New Scaffold Helps to Heal Torn Meniscus
A torn meniscus in the knee is one of the most common injuries that athletes, soldiers, and regular folks tend to suffer from. Surgery is an option, but today’s techniques are severely lacking and often the final result is a lack of healing coupled with osteoarthritis later in life. Now, researchers from Duke University have presented a new implantable scaffold that can help the meniscus to heal better and faster.
Previously, all kinds of scaffolds have been developed to address how torn menisci are surgically treated. These have been shown to have a host of limitations. The new scaffold is derived from pig menisc...
Source: Medgadget - June 20, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Orthopedic Surgery Source Type: blogs
Unity Biotechnology Announces Results from a Senolytics Trial for Osteoarthritis
Unity Biotechnology is the furthest ahead of the growing number of young biotech companies working on senolytic therapies that can selectively destroy harmful senescent cells in aged tissues. The company has already started human trials for osteoarthritis of the knee, using local rather than systemic administration of a small molecule senolytic drug. Other companies in the space, such as Oisin Biotechnologies, will be starting in on human trials for their approaches soon. As noted here, Unity Biotechnology recently announced results from their trial.
The accumulation of senescent cells throughout the body over the y...
Source: Fight Aging! - June 19, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
