Pharmacokinetics and Safety of Atogepant Co ‐administered with Quinidine Gluconate in Healthy Participants: A Phase 1, Open‐Label, Drug‐Drug Interaction Study
AbstractAtogepant, an oral calcitonin gene-related peptide receptor antagonist, is approved for the preventive treatment of migraine. Atogepant is a substrate of P-glycoprotein (P-gp), breast cancer resistance protein, organic anion transporting polypeptide transporters, and cytochrome P450 (CYP)3A4 and 2D6. Quinidine is a strong P-gp and CYP2D6 inhibitor. A phase 1 open-label study evaluated the effect of P-gp and CYP2D6 inhibition by quinidine on the pharmacokinetics of atogepant, and the safety and tolerability of atogepant and quinidine gluconate (QG) when co-administered and when given alone in 33 healthy adults. Ther...
Source: Clinical Pharmacology in Drug Development - May 4, 2024 Category: Drugs & Pharmacology Authors: Ramesh Boinpally,
Lisa Borbridge,
Veronica Wangsadipura Tags: Original Article Source Type: research
Steering benzyl alcohol electrooxidation coupled with hydrogen evolution via hetero ‐interface construction
AbstractIt is still a challenge to develop electrocatalyst for the efficient adsorption and conversion of organic molecule in aqueous media. Herein, a hetero-interface structure based on CuO@Ni(OH)2 is rationally designed to enhance the performance of benzyl alcohol oxidation to benzoic acid. A high Faradaic efficiency of 99% and the yield of 3.09 mmol cm−2 h−1 are achieved at 1.70 V versus reversible hydrogen electrode, outperforming the previously reported electrocatalysts. Furthermore, a membrane-free flow electrolyzer was assembled based on CuO@Ni(OH)2 hetero-interface, exhibiting a much high yielding of ...
Source: AIChE Journal - May 4, 2024 Category: Science Authors: Xin Du,
Wenfu Xie,
Yanfei Wang,
Hao Li,
Jinze Li,
Yang Li,
Yuke Song,
Zhenhua Li,
Jin Yong Lee,
Mingfei Shao Tags: RESEARCH ARTICLE Source Type: research
Narrowband emission from fully bridged triphenylamine derivatives: Insight into effects of structure modification and pressure
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D4CP00906A, PaperQing Zhang, Tao Liu, Yuhua Guo, Yujian Zhang, Chunyan Lv, Yue Zhang, Zexing Cao Triphenylamine derivatives with narrowband emission have drawn growing attention in purely organic thermally activated fluorescence (TADF) materials due to their inspired color purity and flexible molecular design strategy. The combined... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - May 4, 2024 Category: Chemistry Authors: Qing Zhang Source Type: research
Tuning the ion conductivity of Zr-based metal –organic framework ionogels by linker functionalization
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Antonija Ferbezar, Roman Zettl, Katharina Hogrefe, Harald Fitzek, Bernhard Gadermaier, H. Martin R. Wilkening, Ilie Hanzu The conductivity of ionogels, made by embedding an ionic liquid into lithium alkoxide-grafted MOFs from the UiO-66 family, can be improved by 6 orders of magnitude. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - May 4, 2024 Category: Chemistry Authors: Antonija Ferbezar Source Type: research
Stereocontrolled synthesis of the aconitine D ring from D-glucose
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ian A Pocock, Julien Doulcet, Craig Rice, Joseph B Sweeney, Duncan Michael Gill The synthesis of a fully oxygenated aconitine D ring precursor from (D)-(+)-glucose is described. The route features a highly diastereoselective alkynyl Grignard ketone addition and a base-mediated enelactone to 1,3-diketone... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 3, 2024 Category: Molecular Biology Authors: Ian A Pocock Source Type: research
Asymmetric Total Syntheses of Aspilactonol F, Aspiketolactonol and Synthetic Studies Toward Diplofuranoxin
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00549J, PaperRodney Agustinho Fernandes, Sagar B Khandekar The first asymmetric total synthesis of C9 polyketides, aspilactonol F and aspiketolactonol has been achieved. A ring-closing-metathesis has been employed as the key step in the synthesis. The total syntheses... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 3, 2024 Category: Molecular Biology Authors: Rodney Agustinho Fernandes Source Type: research
Metal- and photocatalyst-free approach to visible-light-induced acylation of quinoxalinones
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00630E, PaperWorawat Niwetmarin, Naiyana Saesian, Rungroj Saruengkhanphasit, Chatchakorn Eurtivong, Nopporn Thasana, Somsak Ruchirawat A transition-metal- and photocatalyst-free photochemical acylation strategy driven by the photoexcitation of an electron donor –acceptor (EDA) complex has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 3, 2024 Category: Molecular Biology Authors: Worawat Niwetmarin Source Type: research
Synergistic crystallization regulation and defect passivation for growth of high-quality perovskite single crystals towards ultrasensitive X-ray detection
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA01688B, PaperZhilong Chen, Hu Wang, Jie Fu, Pengxiang Wang, Xin Liu, Hao Dong, Shuang Yang, Yuchuan Shao Organic-inorganic hybrid perovskite single crystals are the most promising candidates for X-ray detection. However, the growth of high-quality large-size single crystals is still challenging. In this work, a passivator assisted... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - May 3, 2024 Category: Chemistry Authors: Zhilong Chen Source Type: research
Growth of p/n-type BiFeO3 thin films for construction of a bilayer p –n junction for photodegradation of organic pollutants
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D4TA01615G, PaperHao-Yun Tu, Xiaoding Qi BiFeO3 (BFO) films were grown on LaNiO3 (LNO) buffered glass substrates under tailored conditions to exhibit either n-type or p-type conductivity, allowing fabrication of a bilayer p –n junction for efficient photodegradation of organic pollutants. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - May 3, 2024 Category: Chemistry Authors: Hao-Yun Tu Source Type: research
Ionic Pairs ‐Engineered Fluorinated Covalent Organic Frameworks Toward Direct Air Capture of CO2
A cascade structure engineering approach is developed to afford an ionic pair-functionalized fluorinated COF (F-COF). The sorbent is featured by ordered structure, high crystallinity, and abundant active sites for CO2 integration. Using 400 ppm CO2 as the feeding gas, high CO2 uptake capacity and facile sorbent regeneration is achieved. Operando spectroscopy-, X-ray-, and neutron-based techniques are deployed to afford information on the CO2 insertion pathway and thermodynamics. AbstractThe covalent organic frameworks (COFs) possessing high crystallinity and capability to capture low-concentration CO2 (400 ppm) from ai...
Source: Small - May 3, 2024 Category: Nanotechnology Authors: Liqi Qiu,
Ming Lei,
Caiqi Wang,
Jianzhi Hu,
Lilin He,
Alexander S. Ivanov,
De ‐en Jiang,
Hongfei Lin,
Ilja Popovs,
Yanpei Song,
Juntian Fan,
Meijia Li,
Shannon M. Mahurin,
Zhenzhen Yang,
Sheng Dai Tags: Research Article Source Type: research
The origin of betaine in mouse oocytes and preimplantation embryos †
Biol Reprod. 2024 May 3:ioae053. doi: 10.1093/biolre/ioae053. Online ahead of print.ABSTRACTBetaine has important roles in preimplantation mouse embryos, including as an organic osmolyte that functions in cell volume regulation in the early preimplantation stages and as a donor to the methyl pool in blastocysts. The origin of betaine in oocytes and embryos was largely unknown. Here, we found that betaine was present from the earliest stage of growing oocytes. Neither growing oocytes nor early preantral follicles could take up betaine, but antral follicles were able to transport betaine and supply the enclosed oocyte. Betai...
Source: Reproductive Biology - May 3, 2024 Category: Reproduction Medicine Authors: Emily R McIntosh Taylor McClatchie Martin Lee Steven H Zeisel Andrea Jurisicova Jay M Baltz Source Type: research
Assessment of parent and alkyl -PAHs in surface sediments of Iranian mangroves on the northern coast of the Persian Gulf: Spatial accumulation distribution, influence factors, and ecotoxicological risks
Chemosphere. 2024 May 1:142176. doi: 10.1016/j.chemosphere.2024.142176. Online ahead of print.ABSTRACTSpatial patterns, potential origins, and ecotoxicological risk of alkylated (APAH) -and parent -(PPAH) polycyclic aromatic hydrocarbons (PAHs) were studied in mangrove surface sediments along the northern coasts of the Persian Gulf, Iran. The mean total concentrations (ngg-1dw) ∑32PAH, ∑PPAHs and ∑APAHs in sediments were 3482 (1689-61228), 2642 (1109-4849), and 840 (478-1273), respectively. The spatial variability was similar among these PAH groups, with the highest levels occurring in Nayband National Marine Park (N...
Source: Chemosphere - May 3, 2024 Category: Chemistry Authors: Ali Ranjbar Jafarabadi Alireza Riyahi Bakhtiari Hamid Moghimi Elena Gorokhova Source Type: research
Phosphorus immobilization/release behavior of lanthanum-modified bentonite amended sediment under the dual effects of pH and dissolved organic carbon
Chemosphere. 2024 May 1:142221. doi: 10.1016/j.chemosphere.2024.142221. Online ahead of print.ABSTRACTLanthanum modified bentonite (LMB) is typical P-inactivating agent that has been applied in over 200 lakes. Dissolved organic carbon (DOC) and high pH restrict the phosphorus (P) immobilization performance of LMB. However, the P immobilization/release behaviors of LMB-amended sediment when suspended to overlying water with high pH and DOC have not yet been studied. In the present work, batch adsorption and long-term incubation experiments were performed to study the combined effects of pH and DOC on the P control by LMB. T...
Source: Chemosphere - May 3, 2024 Category: Chemistry Authors: Xiaodi Li Xiaomeng Zhou Junxia Yu Chunqiao Xiao Ruan Chi Source Type: research
Transformation of dissolved organic matter during groundwater arsenite removal using air cathode iron electrocoagulation
Chemosphere. 2024 May 1:142083. doi: 10.1016/j.chemosphere.2024.142083. Online ahead of print.ABSTRACTDissolve organic matters (DOM) usually showed negative effect on the removal of inorganic arsenic (As) in groundwater by electrochemical approaches, yet which parts of sub-component within DOM played the role was lack of evidence. Herein, we investigated the effects of land-source humic-like acid (HA) on groundwater As(III) removal using air cathode iron electrocoagulation, based on the parallel factor analysis of three-dimensional excitation-emission matrix and statistical methods. Our results showed that the land-source ...
Source: Chemosphere - May 3, 2024 Category: Chemistry Authors: Ying Yuan Jiabao Chen Hao Zhang Yue Wu Yu Xiao Wan Huang Yang Wang Jun Tang Fang Zhang Source Type: research
Organophotoelectrocatalytic C(sp < sup > 2 < /sup > )-H alkylation of heteroarenes with unactivated C(sp < sup > 3 < /sup > )-H compounds
Chem Commun (Camb). 2024 May 3. doi: 10.1039/d4cc01335b. Online ahead of print.ABSTRACTAn organophotoelectrocatalytic method for the C(sp2)-H alkylation of heteroarenes with unactivated C(sp3)-H compounds through dehydrogenation cross-coupling has been developed. The C(sp2)-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions....
Source: Chemical Communications - May 3, 2024 Category: Chemistry Authors: Qinhui Wan Xia-Die Wu Zhong-Wei Hou Yongmin Ma Lei Wang Source Type: research
