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Maternal Mortality: A National Institutes of Health Pathways to Prevention Panel Report
Obstet Gynecol. 2023 Dec 21. doi: 10.1097/AOG.0000000000005488. Online ahead of print.ABSTRACTThe National Institutes of Health's (NIH) Pathways to Prevention panel on postpartum health provides a consensus statement on the evidence, research gaps, and future priorities to prevent maternal morbidity and mortality. The panel reviewed an NIH-commissioned evidence review and workshop that included epidemiologic studies, demonstration interventions, and other maternal morbidity and mortality research to create these national recommendations. The panel concludes that a maternal morbidity and mortality crisis reflects a systemic...
Source: Obstetrics and Gynecology - December 21, 2023 Category: OBGYN Authors: Karina W Davidson Mary Beth Terry Paula Braveman Pamela J Reis Stefan Timmermans John W Epling Source Type: research

SARS-CoV-2 Rebound With and Without Use of COVID-19 Oral Antivirals
MMWR Morb Mortal Wkly Rep. 2023 Dec 22;72(51):1357-1364. doi: 10.15585/mmwr.mm7251a1.ABSTRACTEarly treatment with a first-line therapy (nirmatrelvir/ritonavir [Paxlovid] or remdesivir) or second-line therapy (molnupiravir) prevents hospitalization and death among patients with mild-to-moderate COVID-19 who are at risk for severe disease and is recommended by the National Institutes of Health COVID-19 Treatment Guidelines. On May 25, 2023, the Food and Drug Administration approved nirmatrelvir/ritonavir for treatment of adults at high risk for severe disease. Although antiviral therapies are widely available, they are under...
Source: MMWR Morb Mortal Wkl... - December 21, 2023 Category: Epidemiology Authors: Dallas J Smith Anastasia Lambrou Pragna Patel Source Type: research

Developing research programs that align with the clinical mission
Building a competitive research program within a department of surgery requires a significant commitment by the department and the institution to provide the necessary resources for faculty recruitment, retention of current faculty, and physical space/infrastructure to support research activities. We expanded the academic footprint of our department as demonstrated by the expansion of the department of surgery research funding by 13-fold over a period of 7 years, resulting in an increase in national ranking from 55th place to 10th place in the National Institutes of Health extramural funding. (Source: Surgery)
Source: Surgery - December 19, 2023 Category: Surgery Authors: James F. George, Herbert Chen Source Type: research

Depression in patients with Raynaud ’s phenomenon: A case-control study in the National Institutes of Health's All of Us Research Program
To the Editor: Raynaud ’s phenomenon (RP) is a clinical condition characterized by exaggerated vasospasm, triphasic color change, and in severe cases, ulceration and necrosis of the digits. With an estimated prevalence of 1.6% to 7.2%, RP can occur as an isolated phenomenon (“primary RP”) or in the setting of autoim mune connective tissue disease (most commonly systemic sclerosis [SSc], systemic lupus erythematosus [SLE], or Sjogren’s syndrome [SS]) as so-called “secondary RP.”1 While prior literature has suggested that patients with RP experience increased psychological distress and poorer overall mental healt...
Source: Journal of the American Academy of Dermatology - December 19, 2023 Category: Dermatology Authors: Gloria F. Chen, Katharina S. Shaw, Suzanne Xu, Kimberly B. Hashemi, Rochelle L. Castillo, Ruth Ann Vleugels, Jeffrey M. Cohen Tags: Research letter Source Type: research

The pivotal role of timing of intravenous thrombolysis bridging treatment prior to endovascular thrombectomy
In this study, we found OTD times to have a significant effect on the impact of IVT bridging treatment. Our study shows that among patients with OTD < 2 h bridging treatment may be associated with higher rates of successful recanalization. By contrast, in patients with OTD > 2 h, bridging treatment was associated with worse outcomes. Further time-sensitive randomized trials are needed.PMID:38107442 | PMC:PMC10725133 | DOI:10.1177/17562864231216637 (Source: Adv Data)
Source: Adv Data - December 18, 2023 Category: Epidemiology Authors: Jeremy Molad Hen Hallevi Estelle Seyman Einor Ben-Assayag Tali Jonas-Kimchi Udi Sadeh Ofer Rotschild Naaem Simaan Anat Horev Jose Cohen Ronen R Leker Asaf Honig Source Type: research

Biomarkers have to make sense
In this issue of Osteoarthritis and Cartilage, Kraus and co-workers report that no more than eight serum protein markers are required to separate, on group levels, persons with radiographic knee osteoarthritis (OA) from those free of radiographic OA (non-OA) in hands, hips, knees and spine. Sera from the knee OA cohort Foundation National Institutes of Health (FNIH; n = 596, Kellgren-Lawrence [KL] grade 1-3) were compared with sera from the non-OA multi-joint control cohort Johnston County Osteoarthritis Project (JoCoOA; n = 127, KL = 0). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 18, 2023 Category: Rheumatology Authors: Andr é Struglics Source Type: research

NIH advisory group recommends $14,000 boost in postdoc pay
The minimum starting salaries of U.S. biomedical postdocs should increase to $70,000, up from the current minimum of $56,484, concludes a report released today by an advisory group to the U.S. National Institutes of Health (NIH). “We feel that this is crucial to … protect the U.S. biomedical competitiveness,” said co-chair Shelley Berger, an epigenetics professor at the University of Pennsylvania, during the presentation unveiling the report’s recommendations. If enacted, such a salary boost could impact researchers well beyond the biomedical research community, as many academic institutions across the country set ...
Source: Science of Aging Knowledge Environment - December 15, 2023 Category: Geriatrics Source Type: research

Mechanical thrombectomy for AIS from large vessel occlusion - current trends and future perspectives
Ann Med Surg (Lond). 2023 Oct 4;85(12):6021-6028. doi: 10.1097/MS9.0000000000001385. eCollection 2023 Dec.ABSTRACTStroke is found to be one of the global top causes of mortality and the major factor in years of life with a handicap (DALYs). Ischemic strokes contributed to nearly 70% of all strokes worldwide. For endovascular thrombectomy in acute ischemic stroke with large vessel obstruction (AIS-LVO), using stent retrievers and/or reperfusion catheters has become the gold standard of therapy. The methodology involved keyword-based search in databases like PubMed, Embase, and Google Scholar for recent publications on mecha...
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Gauri Parvathy Rohit C Dey Lakshmi Venkata Simhachalam Kutikuppala Aakansh R Maheshwari Elwy Josey Jyothi S Chintala Mohammed Abdullah Swathi Godugu Source Type: research

Webinar report: stakeholder perspectives on informed consent for the use of genomic data by commercial entities
This report describes the consensus concerns and recommendations raised during the meeting and will be informative for future research on ethical considerations for genomic research in the African research context. (Source: Journal of Medical Ethics)
Source: Journal of Medical Ethics - December 14, 2023 Category: Medical Ethics Authors: Schultz, B., Agamah, F. E., Ewuoso, C., Madden, E. B., Troyer, J., Skelton, M., Mwaka, E., On behalf of H3Africa Ethics and Community Engagement Working Group Tags: Open access Short report Source Type: research

National Institutes of Health R-series Grants portfolio of racism and healthcare, 2017 –2022
Any form of racism in healthcare is an unacceptable barrier to receiving equitable and quality care, further contributing to health disparities among populations. For these reasons, it is critical to have a be... (Source: BMC Public Health)
Source: BMC Public Health - December 14, 2023 Category: Consumer Health News Authors: Judith Aponte and Maria Isabel Rold ós Tags: Research Source Type: research

Gender distribution and NIH funding rank in dermatology leadership: a cross-sectional analysis
AbstractIn examining the influence of National Institute of Health (NIH) funding on gender distribution within dermatology leadership roles, a cross-sectional analysis of Accreditation Council for Graduate Medical Education (ACGME) accredited dermatology residencies was conducted. The gender of leadership faculty was verified using online resources, while institutions were categorized by their 2022 NIH dermatology funding status. Results revealed that male dermatologists predominantly occupied department chair roles, whereas female dermatologists were more frequently found in associate program director roles, regardless of...
Source: Archives of Dermatological Research - December 12, 2023 Category: Dermatology Source Type: research