National Institutes of Health (NIH) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A patent review on aldehyde dehydrogenase inhibitors: an overview of small molecule inhibitors from the last decade
. (Source: Expert Opinion on Therapeutic Patents)
Source: Expert Opinion on Therapeutic Patents - December 1, 2023 Category: Drugs & Pharmacology Authors: Biswajit KunduMalliga R. IyerSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA Source Type: research

Real-World Evidence for Causal Inference —Are We Ready?
In the propensity score matching of patients from the Korea Acute Myocardial Infarction Registry –National Institutes of Health (KAMIR-NIH) registry with an acute myocardial infarction and associated renal impairment by Oh et al,1 angiotensin II receptor blockers (ARBs; n=1945) compared with angiotensin-converting enzyme inhibitors (ACEIs; n=2845) at 3 years of follow-up had a significantly higher incidence of major cardiovascular disease (CVD) events (hazard ratio [HR], 1.34; 95% CI, 1.15 to 1.56). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - December 1, 2023 Category: Internal Medicine Authors: Martin H. Strauss, Krzysztof Narkiewicz, Carl J. Lavie, Stefano Masi Tags: Letters to the editor Source Type: research

Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study
DiscussionA higher proportion of cases experienced early seizures compared to what has been commonly reported in similar studies. Watershed stroke and low Barthel index at discharge were both identified as independent risk factors of PSE in ischemic strokes, which sheds light on the underlying mechanisms that may predispose individuals to post-stroke epilepsy after experiencing an ischemic stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - December 1, 2023 Category: Neurology Source Type: research

Comparison of different diagnostic criteria for sarcopenia assessment in patients with chronic hepatitis C
Rationale: There is neither a gold standard definition nor a universal consensus to diagnose sarcopenia in patients with chronic hepatitis C (CHC). Thus, we aimed to compare the prevalence of sarcopenia and the agreement and discrepancies between the European Working Group on Sarcopenia in Older People (EWGSOP1), the EWGSOP2 and The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project (FNIH) consensuses in CHC. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: T.P. de Vries, A.M. Pires, K. G. Dias Diniz, A.L.S. Chagas, D.A. Vieira, A.M. Kakehasi, V.M.M. Suen, T. Bering, E.A. Colosimo, G.A. Rocha, K.D.P. Farah, L.D. Silva, Nutriclim - Grupo Interdisciplinar e Interprofissional em Nutri ção Clínica e Metabolis Source Type: research

OP28 Are Best Practice Methods for Expert Elicitation Being Applied in NICE Highly Specialized Technology (HST) Submissions? A Review and Evaluation
Expert elicitation is commonly used when there is a paucity of evidence for healthcare decision-making, especially for Highly Specialized Technologies (HST) for rare conditions. This method, however, can introduce uncertainty in or bias the results. Bojke et al. (2021) and INFARMED (Portugal ’s health authority; 2019) issued guidance on how to best conduct elicitation. The current study critically examined how structured expert elicitation has been reported in HST submissions to the National Institute of Health and Care Excellence (NICE). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Ta, A. Kaproulia, E. Vinand, S. Sadler Source Type: research

HTA357 Cost-Comparisons, an Easier Route to NICE Recommendations?
The number of appraisals published annually by the National Institute of Health and Care Excellence (NICE) has increased by 25% between 2017/18 and 2022/23. To ensure timely access to cost-effective treatments, NICE introduced the fast-track appraisal (FTA) process in April 2017, and limited this route to only cost-comparison (CC) analyses in February 2022. Our aim was to identify how many CC analyses have taken place, the type of clinical evidence submitted and the associated funding recommendations. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: J. Armand, A.M. Fontrier, L. Sawyer Source Type: research

HTA263 NICE Listens: Engaging the Public on How Environmental Sustainability Should Be Considered in Health Technology Assessment and Guideline Development
Involving and engaging the public is an essential step to build trust and confidence in HTA organizations. National Institute of Health and Care Excellence (NICE) runs a deliberative public engagement program, NICE Listens. It is used to gather informed public opinion on moral and social value issues. Climate change poses a major threat to our health as well as our planet. NICE Listens was used to explore public opinion on NICE ’s role in making healthcare more environmentally sustainable. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Murray, K. Shah Source Type: research

HTA241 Health Equity and the Health Technology Assessment Process: Are Children and Young People Being Overlooked? A Review of Pediatric National Institute of Health and Care Excellence Technology Appraisals
Drug development for children and young people (CYP) is complex due to methodological, operational, and ethical challenges which are perpetuated in health technology assessments (HTA). Most drugs for CYP are used off label or off license reflecting the current pediatric treatment landscape, although several recent regulatory initiatives aimed to change this trend. We aimed to assess National Institute of Health and Care Excellence (NICE) technology appraisals (TA) for CYP and to identify methodological challenges unique to this population. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: D. Freigofaite, A. Kaproulia, A. Verhoek, G. Sarri Source Type: research

HTA62 A Systematic Review of the New NICE Highly Specialised Technologies Criteria: How Do NICE Judge Criteria 3 and 4 to be Met?
Since February 2022, eligibility for the National Institute of Health and Care Excellence (NICE) Highly Specialized Technologies (HST) program has been based on four revised criteria. Criteria 1 and 2 are based on the rarity of the treated condition and are quantitatively defined, whereas Criterion 3 (significantly shortens life/severely impairs quality of life [QoL]) and Criterion 4 (no satisfactory treatments/significant benefit over existing treatments) require judgement. We investigated how NICE judge Criteria 3 and 4 to be met. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Berkley, S. Campbell-Hill Source Type: research

UK Biobank releases half a million whole-genome sequences for biomedical research
One of the world’s largest databases of whole genomes has just become a lot larger. The British health study known as the UK Biobank today made the full genetic sequences of nearly 500,000 people available to scientists for analysis, more than doubling the size of an earlier data set. Combined with long-term health data on participants, this “treasure trove” has the potential to transform biomedical science, organizers say. Geneticists are excited by the news. Such a large set of sequences provides a uniquely rich resource for studying the biological underpinnings of human health and disease, says Eleftheria Ze...
Source: Science of Aging Knowledge Environment - November 30, 2023 Category: Geriatrics Source Type: research

Adolescent health behavior research.
Health Psychology, Vol 42(12), Dec 2023, 839; doi:10.1037/hea0001314The Adolescent Brain Cognitive Development (ABCD) Study is the largest, long-term study of brain development and child and adolescent health that has ever been conducted in the United States. The ABCD Research Consortium is supported by the National Institutes of Health and includes a central coordinating center, a data analysis and informatics core, and 21 research sites across the country. This special issue of Health Psychology presents some important findings on adolescent health behavior that have recently emerged from the ABCD Study (PsycInfo Databas...
Source: Health Psychology - November 30, 2023 Category: Psychiatry & Psychology Source Type: research

Cheaper microscope could bring protein mapping technique to the masses
Talk to any structural biologist, and they’ll tell you how a cool new method is taking over their field. By flash freezing proteins and bombarding them with electrons, cryo–electron microscopy (cryo-EM) can map protein shapes with near-atomic resolution, offering clues to their function and revealing bumps and valleys that drug developers can target. The technique can catch wriggly proteins in multiple configurations, and it can even capture those that have been off-limits to traditional x-ray analysis because they stubbornly resist being crystallized. Many researchers expect cryo-EM will surpass x-ray crystallography ...
Source: Science of Aging Knowledge Environment - November 27, 2023 Category: Geriatrics Source Type: research

Exercise and aerobic capacity in individuals with spinal cord injury: A systematic review with meta-analysis and meta-regression
by Daniel D. Hodgkiss, Gurjeet S. Bhangu, Carole Lunny, Catherine R. Jutzeler, Shin-Yi Chiou, Matthias Walter, Samuel J. E. Lucas, Andrei V. Krassioukov, Tom E. Nightingale BackgroundA low level of cardiorespiratory fitness [CRF; defined as peak oxygen uptake (V ˙O2peak) or peak power output (PPO)] is a widely reported consequence of spinal cord injury (SCI) and a major risk factor associated with chronic disease. However, CRF can be modified by exercise. This systematic review with meta-analysis and meta-regression aimed to assess whether certain SCI characteristics and/or specific exercise considerations are moderators ...
Source: PLoS Medicine - November 27, 2023 Category: Internal Medicine Authors: Daniel D. Hodgkiss Source Type: research

News at a glance: New cancer institute head, NIH ’s applied research tilt, and bias-free clinical algorithms
BIOMEDICINE U.K. approves CRISPR therapy for sickle cell In a world first, U.K. regulators last week approved a therapy that uses CRISPR, the Nobel Prize–winning gene-editing tool invented in 2012. The treatment has been shown to help people with beta thalassemia and sickle cell disease, both inherited blood disorders that involve defects in the oxygen-carrying protein hemoglobin. It relies on removing blood stem cells from patients, using CRISPR to turn on the gene for a fetal form of hemoglobin, then reinfusing the cells. The therapy, developed by the companies Vertex Pharmaceuticals and CRISPR T...
Source: Science of Aging Knowledge Environment - November 22, 2023 Category: Geriatrics Source Type: research

National priorities for oral health research, Peru 2022-2026: process, experiences and perspectives
This article aims to describe the process used to identify these priorities, which consisted of five phases: i) identification of the strategic objectives of the Ministry of Health, ii) identification of needs in oral health research, iii) review by experts and assessment of needs according to criteria and v) presentation of the priorities. As a result, 12 priorities were obtained, which were subsequently approved by Ministerial Resolution No. 262-2022/MINSA, for a period of 2022-2026. In addition, we provide recommendations for future processes.PMID:37991040 | DOI:10.17843/rpmesp.2023.403.12082 (Source: Revista Peruana de...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - November 22, 2023 Category: International Medicine & Public Health Authors: Adriana Echevarria-Goche Gilmer Solis-S ánchez Lesly V Tuesta-Orbe Christian Andamayo-Flores Margot Vidal-Anzardo Source Type: research