Effective bolus dose of remimazolam for i-gel ® insertion in nonparalyzed patients: a dose-finding study
ConclusionBased on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg−1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL−1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.Study registrationClinicalTrials.gov (NCT05298228); first submitted 6 March 2022. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - April 26, 2024 Category: Anesthesiology Source Type: research
Is time really brain in stroke therapy?: A meta-analysis of mechanical thrombectomy up to 155 h post ictus
ConclusionOur meta-analysis provides evidence that supports the need of further randomized and prospective clinical trials to better assess the effectiveness and safety of MT in these patients. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 26, 2024 Category: Neurosurgery Source Type: research
Letter to editor : Local anesthesia with sedation and general anesthesia for the treatment of chronic subdural hematoma: a systematic review and meta ‑analysis of published cases
AbstractThis critique evaluates the systematic review and meta-analysis titled “Local anesthesia with sedation and general anesthesia for the treatment of chronic subdural hematoma.” The study provides valuable insights into anesthesia techniques’ effectiveness in managing this condition but has limitations, including selection bias, heterogeneity among cases, lack of st andardized protocols, and retrospective design. Despite these limitations, the review contributes to understanding chronic subdural hematoma management but underscores the need for future research to address these shortcomings. (Source: Neurosurgical Review)
Source: Neurosurgical Review - April 26, 2024 Category: Neurosurgery Source Type: research
Cost-effectiveness of surgery for degenerative cervical myelopathy in the United Kingdom
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - April 26, 2024 Category: Neurosurgery Authors: Edward GoacherStefan YardanovRichard PhillipsAlexandru BuduEdward DysonMarcel IvanovGary BartonMike HuttonAdrian GardnerNasir A. QuraishiGordan GrahovacJosephine JungAndreas K. DemetriadesPierluigi VergaraErlick PereiraVasileios ArzoglouJibin FrancisRikin Source Type: research
Is time really brain in stroke therapy?: A meta-analysis of mechanical thrombectomy up to 155 h post ictus
ConclusionOur meta-analysis provides evidence that supports the need of further randomized and prospective clinical trials to better assess the effectiveness and safety of MT in these patients. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 26, 2024 Category: Neurosurgery Source Type: research
Which patients do we need to consider augmentation of muscle active potentials regarding transcranial electrical stimulation motor-evoked potentials monitoring before spine surgery?
Intraoperative neurophysiological monitoring (IONM) is important to prevent spinal cord or nerve root injuries during spinal surgery. Among the various modalities, transcranial electrical stimulation motor-evoked potentials (Tc-MEPs) have been widely used for IONM to assess motor pathway damage [1,2]. However, the amplitudes of compound muscle action potentials (CMAPs) can be suppressed by anesthetics and neuromuscular blockers [2,3]. Furthermore, patient-related factors such as preoperative motor deficits, age, presence of a lesion in the spinal cord, and endogenous diseases may also affect CMAPs [4 –7]. (Source: The Spine Journal)
Source: The Spine Journal - April 26, 2024 Category: Orthopaedics Authors: Takahiro Mui, Hideki Shigematsu, Tsunenori Takatani, Masaki Ikejiri, Sachiko Kawasaki, Hironobu Hayashi, Masahiko Kawaguchi, Yasuhito Tanaka Tags: Clinical Study Source Type: research
Malignant Nerve Sheath Tumour – A Case Report
AbstractMalignant nerve sheath tumors are rare and aggressive soft tissue sarcomas. They contribute to 5 –10% of all soft tissue sarcomas. They can be sporadic, occur in patients with NF1 (neurofibromatosis 1) or can occur after radiation therapy. A high rate of recurrence and hematogenous metastasis is seen in these patients. They are also associated with poor prognosis. A case of malignant nerve sh eath tumor seen in a 44-year-old male with pre-existing NF1 is being discussed here due to the unique nature of the disease and its rarity. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 26, 2024 Category: ENT & OMF Source Type: research
The effect of the collateral cerebrovascular circulation on tolerance to carotid artery cross-clamping and on early outcome after carotid endarterectomy
The Circle of Willis (CoW) serves as the primary source of contralateral blood supply in patients who undergo carotid artery cross-clamping (CC) for carotid endarterectomy (CEA). It has been suggested that CoW ’s anatomy influences CEA outcomes. The aim of this study was to evaluate associations between the cerebral collateral circulation, a positive awake test for intraoperative neurologic deficit after carotid CC and postoperative adverse neurologic events. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 26, 2024 Category: Surgery Authors: Piotr Myrcha, Filipe Pinheiro, Jo ão Rocha-Neves, Jakub Myrcha, Peter Gloviczki Source Type: research
Comparison of central diabetes insipidus (antidiuretic hormone deficiency) and stalk effect in patients with adamantinomatous and papillary craniopharyngioma
AbstractCraniopharyngioma (CP), a rare benign intracranial tumor, is still a major clinical challenge. There are two major histologic phenotypes: papillary CP (PCP) and adamantinomatous CP (ACP). This research aimed to assess the occurrence of central diabetes insipidus (antidiuretic hormone deficiency), the level of prolactin, and the stalk effect between PCP and ACP subtypes prior to and after surgery. Clinical data of CP patients before and after surgical resection of the tumor were analyzed retrospectively. These patients were divided into PCP and ACP groups, in accordance with the pathologic classification. The data o...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
The application value and improved warning criterion of D-wave monitoring in intramedullary spinal cord tumor surgery
The primary treatment method for intramedullary spinal cord tumor (IMSCT) is surgical resection, but this procedure carries a significant risk of neurological damage. Intraoperative neurophysiological monitoring (IONM) has become a necessary adjunctive tool for IMSCT resection. (Source: The Spine Journal)
Source: The Spine Journal - April 26, 2024 Category: Orthopaedics Authors: Ke Li, Xiaorong Tao, Jiajia Liu, Jun Yang, Jiawei Shi, Xiao Wu, Wenqing Jia, Xing Fan, Hui Qiao Tags: Clinical Study Source Type: research
Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma
ConclusionsThis pilot study suggests that insertion of pedicled autologous TPFF/PCF along a GBM resection cavity is safe and feasible. Based on the encouraging response rate in 6-month PFS and OS, larger phase II studies are warranted to assess and reproduce safety, feasibility, and efficacy.Trial registration number and date of registration for prospectively registered trialsClinicalTrials.gov ID NCT03630289, dated: 08/02/2018. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
Letter: Ethical concerns and scientific communication on neuralink device
(Source: Neurosurgical Review)
Source: Neurosurgical Review - April 26, 2024 Category: Neurosurgery Source Type: research
News at a glance: Plants ’ tree of life, conserving U.S. federal lands, and entertaining invertebrate sentience
CONSERVATION
Interior Department boosts restoration
The largest manager of public lands in the United States last week announced it will manage them to promote ecological stewardship, while continuing to allow extractive commercial uses such as mining, oil drilling, and cattle grazing. The Bureau of Land Management (BLM) oversees nearly 1 million square kilometers of federal land, about 10% of the country’s landmass, mostly in Western states. Under a rule issued on 18 April,
BLM will now assess the ecological condition of all hectares it manages
, not just grazing land. The agency will a...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Can science find ways to ease loneliness?
Related podcast
The science of loneliness, making one of organic chemistry’s oldest reactions safer, and a new book series
BY
Sarah Crespi
,
Kelly Servick
,
Ariana Remmel
,
Valerie Thompson
,
Angela Saini
Podcast
25 Apr 2024
One Wednesday in May 2023, a small group gathered at an outdoor café in Barcelona, Spain, sipping coffee in t...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Unravelling pituitary tumours in medically treated patients with acromegaly: the impact of systematic MRI reassessment
CONCLUSION: In most patients with pharmacologically treated acromegaly, we identified a certain or suspected pituitary tumor. These findings were more frequent compared to the routine MRI reports. Based on our results, patients will be considered for a change in long-term treatment modality.PMID:38659302 | DOI:10.1177/02841851241246107 (Source: Acta Radiologica)
Source: Acta Radiologica - April 25, 2024 Category: Radiology Authors: Shahriar Atai Martin Knudtzon Andersen Markus Wiedmann Daniel Dahlberg Kristin Astrid B Øystese Jens Bollerslev Geir Ringstad Ansgar Heck Source Type: research
