A Trial of Proprietary Epigenetic Age Assessments, With No Other Attached Health Data, Provides No Value
You'll recall that a collection of research groups and companies are working to assess the benefits of alpha-ketoglutarate supplementation. The results reported to date focus exclusively on outcomes in epigenetic age assessment, using a proprietary clock algorithm that is not yet open to inspection or analysis. The open access paper I'll point out today is the formal publication of the results announced earlier this year. Since no other information on patient outcomes beyond epigenetic age is provided - such as, for example, measures of inflammation, immune health, and so forth - this data is essentially of no value whatso...
Source: Fight Aging! - December 8, 2021 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
The Relevance of Mitochondrial Metabolism to Cellular Senescence
It is plausible that the mitochondrial dysfunction characteristic of aging increases the pace at which cells become senescent, and harms the efforts of immune cells to remove senescent cells. With age, the burden of senescent cells rises in tissues throughout the body. This is likely an imbalance between the pace of creation and pace of destruction. Regardless, when even a small fraction of the cells in a tissue are senescent, the inflammatory signals they produce become disruptive of tissue function and structure. The open access review here is more focused on the question of how mitochondrial function is changed as a res...
Source: Fight Aging! - December 8, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
BDNF is Important in Muscle Function, Not Just in Brain Function
BDNF levels decline with age. Much of the focus on BDNF has been its role in neurogenesis in the brain. Interventions such as exercise and reversing (or compensating for) the aging of the gut microbiome can boost BDNF levels and cognitive function in animal studies. For a different view on the relevance of BDNF, researchers here report on their investigations of the role of BDNF in muscle tissue, finding that it can upregulate the mitochondrial quality control mechanism of mitophagy, improving muscle function. They also note that obesity can harm muscle tissue function by reducing BDNF levels and thereby causing a loss of ...
Source: Fight Aging! - December 6, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
D-Glyceric Acid Supplementation Improves Mitochondrial Function and Reduces Inflammation in Old People
This open access paper reports on a small study of D-glyceric acid supplementation in older adults. A few weeks of supplementation produced modest gains in mitochondrial function and reductions in measures of inflammation. As is usually the case, it is worth comparing this with the effects of regular exercise, which remains somewhat better at improving mitochondrial function and reducing inflammation in comparison to most of the other available approaches to manipulation of mitochondrial metabolism.
D-glyceric acid (DGA) is a natural organic acid present in very small amounts in vertebrates and plants. Nevertheles...
Source: Fight Aging! - December 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Present Calorie Restriction Mimetics are a Poor Substitute for the Practice of Calorie Restriction
The portion of the medical research and development community that is focused on aging spends most of its time and funding on classes of treatment that cannot outperform good lifestyle choices when it comes to improving health and slowing degenerative aging. Why is this? If billions and decades are to be expended on building a pipeline from fundamental research through to clinical trials, why is the goal only an incremental benefit to health, smaller than that produced by regular exercise, intermittent fasting, or the practice of calorie restriction? Why such a lack of ambition, given the many possible projects that could ...
Source: Fight Aging! - November 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Exercise Delays T Cell Population Aging
Exercise delays the aging of the immune system, particularly changes in the distribution of T cell populations, but what are the underlying mechanisms? Researchers here note the existing focus in the scientific community on mitochondrial metabolism in T cells; exercise beneficially affects mitochondrial function, and energy metabolism is an important determinant of T cell behavior. The researchers suggest, however, that the existing evidence is more supportive of effects based on differences in metabolite production and consumption. It is an interesting viewpoint.
The effect of exercise on immune health has been w...
Source: Fight Aging! - November 23, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously p...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Age-Related Decline of Energy Metabolism in Myeloid Cells as an Important Cause of Neurodegeneration
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function. (Source: Fight Aging!)
Source: Fight Aging! - November 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age,...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Uncoupling in Macrophages as a Strategy to Reduce Inflammation
Researchers here show that forcing mitochondrial uncoupling in macrophages can change their behavior to resolve inflammation. There are a range of therapeutic approaches that might achieve this goal, as mitochondrial uncoupling has been a target for drug discovery for some time, albeit largely for reasons other than the reduction of inflammation. Uncoupling in mitochondria disconnects their activity from the production of ATP to power cellular operations, leading to heat generation instead. This change influences many other cellular processes, largely in beneficial ways; uncoupling occurs during calorie restriction, and in...
Source: Fight Aging! - November 12, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Summarizing What is Known of the INDY Longevity Gene in Flies
That the INDY gene can influence life span was one of the earlier discoveries made once researchers begin to manipulate the life span of short-lived species, spurred by the study of slowed aging via calorie restriction, and searching in earnest for the mechanisms by which metabolism determines the pace of aging. Progress is very slow in this part of the scientific community. Reviews of what is known of INDY are not that different today then they were a decade ago, and it remains an open question as to how relevant this is to humans. That INDY has effects related to preserved intestinal function in flies may just be a refle...
Source: Fight Aging! - November 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Telomerase Reverse Transcriptase Improves Mitochondrial Function
In conclusion, mitochondrial, but not nuclear TERT, is critical for mitochondrial respiration and during ischemia/reperfusion injury. Mitochondrial TERT improves complex I subunit composition. TERT is present in human heart mitochondria, and remote ischemic preconditioning increases its level in those organelles. We conclude that mitochondrial TERT is responsible for cardioprotection and its increase could serve as a therapeutic strategy.
Link: https://doi.org/10.1161/CIRCULATIONAHA.120.051923 (Source: Fight Aging!)
Source: Fight Aging! - November 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Glutathione Delivery via Iontophoresis Increases Gluthathione Levels in Blood Samples
Glutathione is a mitochondrial antioxidant, and additional antioxidant capacity in mitochondria appears to be beneficial to long-term health, improving mitochondrial function and overall health. Mitochondria conduct the energetic process of producing ATP, used to power the cell, with a flux of oxidative molecules as a side-effect. With age, mitochondria tend to become less efficient and produce more oxidizing molecules, harmful to the cell. Glutathione levels decline with age, which may contribute to this age-related mitochondrial dysfunction.
Oral supplementation with gluthatione doesn't have any effect, unfortunat...
Source: Fight Aging! - November 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
