Discussing the Target Cells for Allotopic Expression of Mitochondrial DNA
The Strategies for Engineered Negligible Senescence (SENS) view of the relevance of mitochondrial DNA damage to aging is that certain types of damage, large deletions for example, can produce pathological mitochondria that are both broken and able to outcompete their peers. Clones of the original damaged mitochondrion take over a cell, turning it into an exporter of large amounts of damaging reactive molecules. Only a small number of cells are affected by this type of damage in aged tissues, but it doesn't take that many cells acting in this way to produce pervasive changes to the signaling environment, as well as signific...
Source: Fight Aging! - January 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Angiotensin II Increases Oxidative Stress in Aging
Researchers here suggest that angiotensin II expression is maladaptive in the context of aging, provoking greater oxidative stress and harmful downstream consequences for cell and tissue function. If looking to produce therapies based on interfering in angiotensin II receptor signaling, an approach already well established in the treatment of hypertension, the question is always the tradeoff between loss of function and avoidance of damage. Few if any molecular interactions in the body are entirely dispensable, and angiotensin II signaling is involved in a range of normal cellular processes. That said, this topic is well e...
Source: Fight Aging! - December 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Level Survey of Mechanisms of Brain Aging
Ultimately, we live and die as the brain lives and dies. The rest of the body is a support system, a complex one to be sure, but probably not as complex as the brain. Repairing the cell and tissue damage of aging in the body seems a more tractable challenge, in that replacement is always an option. Replace cells, replace the gut microbiome, add new tissues grown in a lab to organs like the liver and thymus, or grow a new body and transplant the brain. A path of ever increasing control over cells, cell signaling, and regeneration implies a future in which all damaged tissue can be replaced in one way or another ... except f...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Role of SIRT6 in Aging
While much the history of work on sirtuins is one of disappointing results, the majority of that work involved SIRT1. Both SIRT3 and SIRT6 may be more interesting, based on animal studies conducted since the SIRT1 era. SIRT3 localizes to the mitochondria, and mitochondrial function is important in the context of aging. Researchers have shown that SIRT3 upregulation in mice improves hematopoietic stem cell function. SIRT6 upregulation, however, has been shown to modestly extend life in mice, there is a larger body of work surrounding its effects on metabolism than is the case for SIRT3, and at least one group is attempting ...
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Age-Related Mitochondrial DNA Mutation Does Not Appear to Influence Cancer, and Vice Versa
Mitochondria have their own genome, and damage to this mitochondrial DNA is thought to be involved in aging. Some forms of mitochondrial DNA damage can result in mitochondria that are both dysfunctional and have a selection advantage over their unmutated peers, allowing them to overtake a cell, turning it into an exporter of harmful oxidative molecules. Cancer is an age-related condition, in the sense that the risk of suffering cancer grows with age, but this interesting paper provides evidence to suggest that there is little to no mechanistic link between mitochondrial DNA damage and cancer.
Mitochondria are smal...
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging.
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/
Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Assessing Mitochondrial Transfer Into Senescent Cells In Vitro
Researchers here report on in vitro experiments to show that introducing functional mitochondria into a cell culture containing senescent cells reduces markers of senescence. It is an interesting question as to how this would work in living tissue, where the numbers of senescent cells are low, and mitochondria will be introduced into all cells. Since several companies are developing mitochondrial transfer as a therapy to treat the loss of mitochondrial function that is characteristic of age-related disease, we'll find out in the years ahead. Those groups are not specifically targeting cellular senescence, but can hardly av...
Source: Fight Aging! - December 8, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Autophagy in Tauopathies Such as Alzheimer's Disease
Autophagy is the name given to a collection of maintenance processes responsible for tagging and recycling damaged, excess, or harmful proteins and structures in the cell. Better maintenance of molecular machinery means a better operation of cells and tissues. Upregulation of autophagy is a feature of many of the approaches shown to modestly slow aging in animal studies, those that mimic some of the biochemistry of calorie restriction. Calorie restriction itself is thought to improve health and longevity primarily through autophagy.
Here, researchers look at autophagy in the context of neurodegenerative conditions. ...
Source: Fight Aging! - December 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting the Aging of the Immune System in the Context of Frailty
The immune system declines into a state of incapacity (immunosenescence) and chronic inflammation (inflammaging) with advancing age. Unresolved inflammatory signaling is disruptive of tissue function in many ways, from reduced stem cell activity to pathologically altered somatic cell behavior. It is thought to be important in the declining muscle mass and strength that contributes to age-related frailty. Thus addressing immune aging is a significant and important target in the treatment of aging as a whole.
Frailty is a highly prevalent geriatric syndrome that has attracted significant attention from physicians an...
Source: Fight Aging! - November 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Anemia in cardiac failure : Needs little more attention
HF is the inability (or reduced ability) to supply oxygen and other nutrients to fulfill the body’s demands. In the process, the heart either fights or flights, and results in symptoms due to hemodynamic alterations, or adversities of neuro-hormonal activation.
Now, what is Anemia? Anemia is a condition with reduced or dysfunctional RBCs. that directly interferes with oxygen delivery to tissues. It is not at all a coincidence, the core functions of the heart and blood are strikingly similar and intertwined. While the heart is the powerhouse of the circulatory system, without good-quality blood, the greatness of th...
Source: Dr.S.Venkatesan MD - November 19, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized anemia in cardiac failure Source Type: blogs
