Notes from the Aging Research and Drug Discovery 2021 Conference
The Longevity.technology team has been publishing notes on the recent Aging Research and Drug Discovery (ARDD) conference, one of the few events at the end of this year to be held in person again after the long pandemic hiatus. It was a challenge for conference organizers to look into the crystal ball six to twelve months in advance and commit to a late 2021 event, but some did. The 2022 conference season will no doubt be interesting, as restrictions relax sufficiently for reliable travel and advance scheduling, and a few years of the suppressed urge to network is finally unleashed. The ARDD conferences are more focused on...
Source: Fight Aging! - September 14, 2021 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial-Derived Peptides as Targets for Cardiovascular Disease Therapies
This review takes a look at a number of peptides related to mitochondrial function, and which are thought to potentially provide therapeutic benefit. Some are interesting in the context of aging. As is the case for most peptides with enough scientific literature to justify a review paper, availability and use is somewhat ahead of the science. Peptide manufacture is easy enough and cheap enough that most studied peptides can be purchased from established manufacturers. That certainly doesn't mean that they are in fact useful at the end of the day! This marketplace is very much like the supplement marketplace in that respect...
Source: Fight Aging! - September 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Evolutionary Layering of the Mechanisms of Aging
Aging is the accumulation of molecular damage and the consequences of that damage. This molecular damage and its immediate consequences are comparatively simple to describe, but the damage takes place in a fantastically complex system of cells, cellular interactions, tissues, organs, organ interactions, and more. Every problem causes cascading, interacting chains of cause and effect, hard to pick apart via inspection and hard to reason about. Cellular metabolism and tissue structure and function are far from fully mapped, and aging involves sweeping changes throughout the organism and its countless subsystems.
Today...
Source: Fight Aging! - September 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Successfully Treating Fibrosis in Mice via the Senolytic Strategy of Bcl-2 Inhibition
It has to be said, today's research materials make for a fascinating read. A group of scientists, in 2021, a decade into the general acceptance of the importance of cellular senescence as a phenomenon, conducts a study of lung fibrosis in which they achieve a reversal of that fibrosis using a bcl-2 inhibitor, venetoclax, and then publish a paper that fails to mention cellular senescence even once.
Fibrosis is a dysfunction of tissue maintenance, producing scar-like collagen deposits that disrupt tissue function. There is a weight of evidence for fibrosis as a phenomenon to be driven by the presence of senescent cell...
Source: Fight Aging! - September 6, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
