My EF is 45%, I am unable to walk to the mall, but …
This a story from a middle aged IT professional who had recently suffered from a cardiac event. His concern is, he has an ejection fraction (EF) of 45%, finds difficult to walk to the nearby mall ,while his neighbour, also a heart patient, has only 32% EF , but goes for cycling and hiking ! He finds this very odd and totally unacceptable. .He desperately needed an answer from his cardiologist.
How is this possible, doctor? I am sort of depressed for two reasons. You are saying, I had only a mild heart attack and recovered well with no significant blocks in the angiogram, but, I still find it difficult to do routine ...
Source: Dr.S.Venkatesan MD - November 8, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized eejection fraction ef% fallacies in ef% Source Type: blogs
Towards Electromagnetic Interventions to Improve Mitochondrial Function
The use of electromagnetic fields to manipulate cell activity is understudied in comparison to the use of small molecules, so it is always possible that meaningfully beneficial electromagnetic therapies might be awaiting discovery. The present lack of said therapies may be much more a matter of the lack of funding and experienced research groups needed for exploration and follow through rather than either an inherently greater difficulty in developing such therapies or an inherent lack of potential in this strategy. Here, researchers discuss whether one can use electromagnetism to manipulate the function and quality contro...
Source: Fight Aging! - November 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A DNA Methylation Marker of Age in Mitochondrial DNA
In this study, we present a novel, reliable, PCR-based (i.e., sequence-specific) 6mA detection method that is free of technological artifacts and show in several genetic models that relative 6mA levels at different mtDNA sites (these levels actually show that how many percent of the individual mitochondrial genomes present in a given tissue sample are methylated at a selected adenine nucleobase) are significantly related to the age of the organism. Thus, N6-adenine methylation is an inherent process in the organization of mitochondrial genomes too.
These results suggest that the widely observed age-related decline i...
Source: Fight Aging! - October 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mitochondrial DNA Mislocalization is an Important Driver of the Senescence-Associated Secretory Phenotype
The presence of lingering senescent cells characteristic of aged tissues is harmful due to the pro-inflammatory signaling produced by these cells, the senescence-associated secretory phenotype (SASP). Researchers here show that mitochondrial stress leading to mislocalization of mitochondrial DNA and a consequent inflammatory response is important in the generation of the SASP. Mammalian cells have evolved an innate immune response to the presence of foreign DNA, but mitochondrial DNA is sufficiently bacteria-like that it can trigger this response. Thus the mitochondrial stress and dysfunction that takes place in aged tissu...
Source: Fight Aging! - October 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Calorie Restriction Improves Pancreatic Function in Aging Mammals
Beta cells in the pancreas produce insulin and are essential to the regulation of glucose metabolism. Dysfunction in this cell population causes diabetes, whether the origin is autoimmune destruction of beta cells (type 1 diabetes) or senescence of beta cells brought on by obesity (type 2 diabetes). Aging also impairs beta cell function through some of the same mechanisms, such as cellular senescence and constant, unresolved inflammatory signaling. The practice of calorie restriction slows aging, albeit to a greater degree in short-lived species than in long-lived species, and so it is not surprising to see that calorie re...
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Novel Approach to Exploiting the Peculiar Biochemistry of Senescent Cells to Produce a Highly Targeted Senolytic
Senolytic drugs selectively destroy senescent cells. First generation senolytic drugs generally target apoptosis-resistance mechanisms and have off-target effects, though these appear quite acceptable in the case of dasatinib and quercetin, given the potential benefits. Nonetheless, researchers are expending a great deal of effort to search for ways to produce far more selective targeting of senescent cells. One example is the category of prodrugs that are only transformed into their cytotoxic form via the activity of β-galactosidase, upregulated in senescent cells. Another type of prodrug employs iron metabolism peculiar...
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arguing for Mitochondrial DNA Damage to Spread Between Neurons in Parkinson's Disease
The most noticeable symptoms of Parkinson's disease occur because of the loss of a small but vital population of dopamine-generating neurons in the brain. The condition is associated with the spread of misfolded, aggregated α-synuclein throughout brain tissue. α-synuclein is one of the few molecules in the body capable of misfolding in ways that encourage other molecules o α-synuclein to also misfold in the same way. It can thus spread from cell to cell, perhaps carried in extracellular vesicles. It is thought that misfolding of α-synuclein often first occurs in the intestines, and only then spreads to the brain throug...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continued Study of Urolithin A to Improve Mitochondrial Function
Urolithin A is one of a number of compounds available as supplements that can improve mitochondrial function in older individuals. Like others, urolithin A may function by improving the mitochondrial quality control process of mitophagy, responsible for removing damaged and worn mitochondria. Mitophagy becomes less efficient with age, and this is one of the contributing factors to age-related loss of mitochondrial function and its harmful impact on tissues. Like other supplement based approaches to improving mitochondrial function, it is likely that regular exercise delivers larger gains than those demonstrated for supplem...
Source: Fight Aging! - October 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Selection of Mechanisms Relevant to Atherosclerosis
Atherosclerosis is the growth of fatty lesions in blood vessel walls, leading eventually to a rupture and blockage to cause a heart attack or stroke, and along the way causing narrowing of blood vessels sufficient to lead to heart failure and dysfunction elsewhere in the body as the supply of blood to tissues is reduced. Today's paper on this topic is a little disorganized, something of a random assembly of thoughts on mechanisms relevant to the development of atherosclerosis. Atherosclerosis is the single largest cause of human mortality, and attempts to treat contributing mechanisms have so far not stopped it from being ...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Synaptic Dysfunction Precedes the Death of Neurons in Parkinson's Disease
Parkinson's disease is characterized by the loss of dopamine-generating neurons, with the inflammatory pathology leading up to that issue thought to be driven by the spread of misfolded α-synuclein. Dysfunctional mitochondrial quality control can make these dopamine-generating neurons more vulnerable to the underlying pathology, however, and thus a fraction of Parkinson's disease arises in people with mutations that cause this sort of dysfunction. That has directed researchers towards mitochondrial function as an important factor in the progression of the condition, but it will probably turn out to be more useful to focus...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inflammaging in the Aged Kidney
With age, the immune system becomes simultaneously less capable (immunosenescence) and more active and inflammatory (inflammaging). This constant, low-grade, unresolved inflammatory activity is driven by a range of different mechanisms. For example, senescent cells energetically secrete pro-inflammatory signals, and their numbers grow with age in tissues throughout the body. Further, age-related issues in cell function can lead to fragments of DNA from mitochondria and the nucleus leaking into the cytoplasm, where they trigger innate immune mechanisms intended to detect pathogens. Constant, unresolved inflammation is harmf...
Source: Fight Aging! - September 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
