Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Transplantation as a Treatment for Kidney Damage
It is interesting see an increased focus on assessing the ability of mitochondrial transplantation to be useful in a variety of circumstances, not just as a treatment to reduce the mitochondrial dysfunction that occurs with aging. The limiting factor in bringing mitochondrial transplantation to the clinic is chiefly the speed at which the research and development communities can achieve the logistical advances needed to reliably produce enough mitochondria to deliver to an entire organ (at first), and the whole body (later). It is likely the case that mitochondria will have to be patient-matched by haplotype of mitochondri...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Examining the Details of Mitochondrial Dysfunction in the Aging Mouse Heart
Every cell contains hundreds of mitochondria, hard at work to produce the chemical energy store molecule adenosine triphosphate (ATP), used to power cellular activities. Mitochondria are complex structures, the evolved descendants of ancient symbiotic bacteria that are now integrated into the cell. At their center is the electron transport chain, a collection of protein complexes that conducts the energetic chemical reactions needed to make ATP. Mitochondria bear copies of a remnant circular genome, DNA distinct from that in the cell nucleus, which encodes some of the mitochondrial proteins necessary for mitochondrial func...
Source: Fight Aging! - July 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Copy Number in Immune Cells Strongly Correlates with 15-Year Mortality
We examined a random population sample in 2003/2005 (n = 9,360, age 45-69, the HAPIEE project) and followed up for 15 years. Using a nested case-control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake, and education.
The age-sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 and 1.59; an increased risk ...
Source: Fight Aging! - July 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SENS Research Foundation 2023 Annual Report
The SENS Research Foundation has released its 2023 annual report. This is one of the few non-profit organizations focused on advancing the state of research and development of rejuvenation therapies. It exists in the same family tree as the Methuselah Foundation and LEV Foundation, and all three now have somewhat different areas of focus within the same broad outline. In comparison to the SENS Research Foundation, the Methuselah Foundation gives more attention to tissue engineering, while LEV Foundation is presently investigating combinations of potential rejuvenation therapies in animal models, a sorely neglected area of ...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
A Small Molecule to Reduce Mitochondrial Generation of Oxidative Stress
Researchers here report on an improved version of compounds known to reduce the generation of oxidizing molecules by mitochondria. Mitochondrial dysfunction can produce sustained oxidative stress that changes cell behavior for the worse, contributing to aspects of aging. That targeting antioxidants to the mitochondria or upregulating natural antioxidant molecules can produce some benefit to health suggests that the size of the contribution is meaningful. The details matter, however, and as cells use mild mitochondrial oxidative stress to trigger beneficial maintenance activities, with the metabolic response to exercise bei...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Aging in the Context of Kidney Function
Mitochondria are responsible for producing the chemical energy store molecules, adenosine triphosphate (ATP), used to power cellular processes. Unfortunately, mitochondria become dysfunctional with age, in complex ways and for complex reasons that are not yet fully understood. Mitochondria evolved from symbiotic bacteria, and still act much like bacteria inside the cell. They carry a remnant circular genome, the mitochondrial DNA, they replicate as needed to keep their numbers up, they can fuse together and pass around component parts, they are recycled when worn or damaged by the quality control mechanisms of mitophagy. W...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Dysfunction as a Contribution to Muscle Aging
How much of the characteristic loss of muscle mass and strength that takes place with aging is the result of mitochondrial dysfunction? Mitochondria produce the chemical energy store molecules needed to power cellular processes, but in addition to the loss of this capacity, dysfunction in mitochondria can also generate oxidative stress that further impairs cell function. Some degree of mitochondrial dysfunction emerges from damage to mitochondrial DNA, but it is also the case that age-related changes in gene expression reduce the efficiency of mitochondrial quality control, the process of mitophagy responsible for removing...
Source: Fight Aging! - July 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Transplant Alleviates Stress-Induced Mitochondrial Dysfunction in Rat Brains
Mitochondrial transplantation is potentially a way to restore more youthful mitochondrial function without the need for a far greater understanding of exactly how exactly mitochondria become dysfunctional with age. Cells will readily ingest mitochondria from the surrounding intercellular space and make use of them. If those mitochondria work well in comparison to the state of the cell's native mitochondria, then cell function will be improved for some time. Animal studies suggest that the effect is lasting. In that context, it is always interesting to see studies in which outcomes are assessed for mitochondrial transplanta...
Source: Fight Aging! - June 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Dancing Organelles, AI Resources, Distracting Animations, Timed Tests & Micro-credentials | TAPP 138
In Episode 138 ofThe A&P Professor podcast for anatomy& physiology faculty, host Kevin Patton discusses somenew thinking about organelle function, whydecorative animations are not a good idea in our teaching slides, news aboutWendy Riggs and the 2023 HAPS President ' s Medal, why Idon ' t like timed tests, resources forAI in the curriculum, and whymicro-credentials are our friends. With all that, how is that we left out any mention ofcarbaminohemoglobin?00:00 | Introduction00:50 | Wendy Riggs Wins Big04:173 | Curricular Resources for AI08:55 | Timed Online Tests24:12 | Micro-credentials for Professional Develo...
Source: The A and P Professor - June 9, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
