Mitochondrial DNA Mislocalization is an Important Driver of the Senescence-Associated Secretory Phenotype

The presence of lingering senescent cells characteristic of aged tissues is harmful due to the pro-inflammatory signaling produced by these cells, the senescence-associated secretory phenotype (SASP). Researchers here show that mitochondrial stress leading to mislocalization of mitochondrial DNA and a consequent inflammatory response is important in the generation of the SASP. Mammalian cells have evolved an innate immune response to the presence of foreign DNA, but mitochondrial DNA is sufficiently bacteria-like that it can trigger this response. Thus the mitochondrial stress and dysfunction that takes place in aged tissues can provoke some fraction of the chronic inflammation of aging. This process appears to be particularly pronounced in senescent cells.

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP). Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated.

Source: Fight Aging! - October 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs