Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI)
This study has been approved by the Institutional Review Board. All patients or surrogates will provide written consent prior to enrolment and any study intervention. Metformin is a widely available, inexpensive medication with a long track record for safety, which if effective would be accessible and easy to deploy. We describe the study methods using the Standard Protocol Items for Randomized Trials framework and discuss key design features and methodological decisions. LiMiT AKI will investigate the feasibility and safety of metformin in critically ill patients with sepsis at risk of SA-AKI, in preparation for a future ...
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Saraiva, I. E., Hamahata, N., Huang, D. T., Kane-Gill, S. L., Rivosecchi, R. M., Shiva, S., Nolin, T. D., Chen, X., Minturn, J., Chang, C.-C. H., Li, X., Kellum, J., Gomez, H. Tags: Open access, Intensive care Source Type: research
Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)--a study protocol
Introduction
Cardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a reduction in cardiac mortality and recurrent myocardial infarction. This trial assesses the feasibility of a home-based CR programme delivered using a mobile application (app).
Methods
The Rehabilitation through Exercise prescription for Cardiac patients using an Artificial intelligence web-based Programme (RECAP) randomised controlled feasibility trial is a single-centre prospective study, i...
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Witharana, P., Chang, L., Maier, R., Ogundimu, E., Wilkinson, C., Athanasiou, T., Akowuah, E. Tags: Open access, Cardiovascular medicine Source Type: research
Informed consent and trial prioritization for clinical studies during the COVID-19 pandemic. Stakeholder experiences and viewpoints
DiscussionPotential response strategies for challenges with informed consent and study prioritization partly share common ground. High quality procedures for study prioritization, for example, seem to be a core response strategy in dealing with informed consent challenges. Especially in a research environment with particularly high uncertainty regarding potential treatment effects and further limitations for valid informed consent should the selection of clinical trials be very well justified from a scientific, medical, and ethics viewpoint. (Source: PLoS One)
Source: PLoS One - April 30, 2024 Category: Biomedical Science Authors: Stefanie Weigold Source Type: research
Repurposing of dextromethorphan as an adjunct therapy in patients with major depressive disorder: a randomised, group sequential adaptive design, controlled clinical trial protocol
This study was approved by the Institutional Ethics Committee of All India Institute of Medical Sciences, Bhubaneswar, India, and the study conformed to the provisions of the Declaration of Helsinki and ICMR’s ethical guidelines for biomedical research on human subjects (2017). Written informed consent will be obtained from the participants before recruitment. The results of this study will be published in peer-reviewed publications.
Trial registration number
NCT05181527. (Source: BMJ Open)
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Maji, S., Mohapatra, D., Jena, M., Srinivasan, A., Maiti, R. Tags: Open access, Mental health Source Type: research
On Freedom from Remorse (Avipratis āra/Avippaṭisāra): Its Place on the Well-Trodden Path from Moral Discipline to Samādhi Meditation
AbstractThe primary objective of this study is to shed light on the role and significance of freedom from remorse (avipratis āra/avippa ṭisāra) in the cultivation of Buddhist concentration (sam ādhi) meditation. The study delves into the progression fromavipratis āra/avippa ṭisāra tosam ādhi, examining how moral discipline influences an individual ’s conscience and, consequently, meditation. We commence by examining the well-established path of cultivation leading towardsam ādhi. A comprehensive study was undertaken to understand the termavipratis āra/avippa ṭisāra, its significance for Buddhist meditation...
Source: Mindfulness - April 30, 2024 Category: Psychiatry & Psychology Source Type: research
Clinical and laboratory features of sickle cell disease s/d punjab: impact of hbf and hydroxyurea
Conclusion: SD Punjab is the third most common SCD genotype in Oman and was associated with recurrent VOC, ACS, AVN, and gall stones comparable to other SCD genotypes. Patients with> 3 VOC/year had significantly increased incidence of Stroke, AVN, and gallstones. However, HU was not associated with improved prognosis and better survival in this cohort of patients.Keywords: Sickle Cell Disease; Haemoglobin SD Punjab; vaso-occlusive crises; acute chest syndrome; Avascular Necrosis; HbF; hydroxyurea. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: r. Salam Al-Kindi, Isra Al-Busaidi, Anil Pathare Source Type: research
Translational Strategies for Understanding Neural Circuitry Dysfunction in Schizophrenia
The locus of the disease process in most psychiatric disorders, the human brain, is an appropriately privileged organ that is currently not subjected to biopsy in the diagnostic process of psychiatric illnesses for both clinical and ethical reasons. As a result, research in psychiatry has lacked the means to directly study the molecular and structural alterations of the brain at cell type-specific resolution in the living state, a key strategy that has led to major advances in understanding diseases of other organs that are biopsied. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: David Lewis Source Type: research
Evaluating the Impact and Effectiveness of Flint's Community Ethics Review Board (CBOP-CERB): A Pilot Study
Prog Community Health Partnersh. 2024;18(1):e5-e6.NO ABSTRACTPMID:38682407 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 29, 2024 Category: International Medicine & Public Health Authors: Stephanie Solomon Cargill Bryan Spencer Briah Spencer Source Type: research
Hopelessness and Social Support among Cancer Patients in Saudi Arabia
CONCLUSION: The findings of the present study suggest that the levels of hopelessness in cancer patients are moderate, and the levels of social support received by participants are high. In addition, the relationship between the levels of hopelessness and the levels of social support received is inversely proportional.PMID:38679998 | DOI:10.31557/APJCP.2024.25.4.1363 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hawazen Rawas Jennifer De Beer Osamah Alturki Mohammed Altorki Tareq Alhelali Anas Althagfi Nawaf Faisal Faisal Albalawi Muhammad Anwar Khan Source Type: research
The Evolution of Telehealth in Heart Failure Management: The Role of Large Language Models and HerzMobil as a Potential Use Case
This study examines the integration of LLMs in heart failure management, with a focus on HerzMobil as a pioneering telehealth program. The technical underpinnings of LLMs, their current applications in the medical field, and their potential to enhance telehealth services, have been explored. The paper highlights the benefits of LLMs in patient interaction, clinical documentation, and decision-making processes. Through the HerzMobil case study, improvements in patient self-management and reductions in hospital readmission rates have been observed, showcasing the successful application of telehealth in chronic disease manage...
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Hillary Farmer Karl Kreiner Thomas Sch ütz Gerhard P ölzl Christian Puelacher G ünter Schreier Source Type: research
Symbiosis of Technology and Ethics: Preliminary Results of an Inquiry into the Moral Dimensions in the Use of Robotic Systems in Patient Care
Stud Health Technol Inform. 2024 Apr 26;313:41-42. doi: 10.3233/SHTI240009.ABSTRACTThe present study aims to describe ethical and social requirements for technical and robotic systems for caregiving from the perspective of users. Users are interviewed in the ReduSys project during the development phase (prospective viewpoint) and after technology testing in the clinical setting (retrospective viewpoint). The preliminary results presented here refer to the prospective viewpoint.PMID:38682502 | DOI:10.3233/SHTI240009 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Carolin Mirbeth Christoph Ohneberg Inge Eberl Source Type: research
The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms
Glob Health Action. 2024 Dec 31;17(1):2326253. doi: 10.1080/16549716.2024.2326253. Epub 2024 Apr 29.ABSTRACTEffective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. The Tools for Integrated Management of Childhood Illness (TIMCI) project aims to support healthcare providers to identify and manage severe illness, whilst promoting resource stewardship, by introducing pulse oximetry and clinical decision support algorithms (CDSAs) to primary care facilities in India, Kenya, Senegal and Tanzania. Health impact is assessed through: a ...
Source: Global Health Action - April 29, 2024 Category: International Medicine & Public Health Authors: Fenella Beynon H élène Langet Leah F Bohle Shally Awasthi Ousmane Ndiaye James Machoki M'Imunya Honorati Masanja Susan Horton Maymouna Ba Silvia Cicconi Mira Emmanuel-Fabula Papa Moctar Faye Tracy R Glass Kristina Keitel Divas Kumar Gaurav Kumar Gillian Source Type: research
Evaluating the Impact and Effectiveness of Flint's Community Ethics Review Board (CBOP-CERB): A Pilot Study
Prog Community Health Partnersh. 2024;18(1):e5-e6.NO ABSTRACTPMID:38682407 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 29, 2024 Category: International Medicine & Public Health Authors: Stephanie Solomon Cargill Bryan Spencer Briah Spencer Source Type: research
Practice Guidelines for Central Venous Access 2020 - Time for German Guidelines
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Apr;59(4):252-262. doi: 10.1055/a-1690-5730. Epub 2024 Apr 29.ABSTRACTThe American Society of Anesthesiologists released practice guidelines for central venous access in 2020, and the entire world literature was examined for evidence on how to perform the entire process with best practice and minimal risk and harm to the patient. These guidelines may serve as a gold standard for individual procedural steps, allowing practitioners and hospital departments to critically question the own standard and improve upon them.We interpreted the guidelines for individual procedural ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Wolf Armbruster R üdiger Eichholz Thomas Notheisen Source Type: research
The Evolution of Telehealth in Heart Failure Management: The Role of Large Language Models and HerzMobil as a Potential Use Case
This study examines the integration of LLMs in heart failure management, with a focus on HerzMobil as a pioneering telehealth program. The technical underpinnings of LLMs, their current applications in the medical field, and their potential to enhance telehealth services, have been explored. The paper highlights the benefits of LLMs in patient interaction, clinical documentation, and decision-making processes. Through the HerzMobil case study, improvements in patient self-management and reductions in hospital readmission rates have been observed, showcasing the successful application of telehealth in chronic disease manage...
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Hillary Farmer Karl Kreiner Thomas Sch ütz Gerhard P ölzl Christian Puelacher G ünter Schreier Source Type: research
