Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a nafld/nash mouse model.
Authors: Tessitore A, Mastroiaco V, Vetuschi A, Sferra R, Pompili S, Cicciarelli G, Barnabei R, Capece D, Zazzeroni F, Capalbo C, Alesse E
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. It can progress to nonalcoholic steatohepatitis (NASH) and, in a percentage of cases, to hepatocarcinogenesis. The strong incidence in western countries of obesity and metabolic syndrome, whose NAFLD is the hepatic expression, is thought to be correlated to consumption of diets characterized by processed food and sweet beverages. Previous studies described high-fat diet-induced liver tu...
Source: Oncotarget - June 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple ‐negative breast cancer
Abstract
High animal fat consumption is associated with an increase in triple‐negative breast cancer (TNBC) risk. Based on previous MRI studies demonstrating the feasibility of detecting very early non‐palpable mammary cancers in simian virus 40 large T antigen (SV40TAg) mice, we examined the effect of dietary fat fed from weaning to young adulthood in this model of TNBC. Virgin female C3(1)SV40TAg mice (n = 16) were weaned at 3–4 weeks of age and then fed either a low fat diet (LFD) (n = 8, 3.7 kcal/g; 17.2% kcal from vegetable oil) or a high animal fat diet (HAFD) (n = 8, 5.3 kcal/g; 60% kcal from lard). A...
Source: NMR in Biomedicine - June 29, 2017 Category: Radiology Authors: Devkumar Mustafi, Sully Fernandez, Erica Markiewicz, Xiaobing Fan, Marta Zamora, Jeffrey Mueller, Matthew J. Brady, Suzanne D. Conzen, Gregory S. Karczmar Tags: RESEARCH ARTICLE Source Type: research
High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin ‐induced type 1 diabetic mice
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - June 20, 2017 Category: Cytology Authors: Adriana Lelis Carvalho, Victoria E. DeMambro, Anyonya R. Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco Jos é Albuquerque de Paula, Katherine J. Motyl Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Dietary Intake of Structured Lipids with Different Contents of Medium ‐Chain Fatty Acids on Obesity Prevention in C57BL/6J Mice
In this study, MLCT with high content of MCFA (30%, w/w) has been firstly prepared, and it showed the great potential in obesity prevention for C57BL/6J mice. Thus, it can be further applied to lose weight as cooking oil for stir‐frying use. (Source: Journal of Food Science)
Source: Journal of Food Science - June 20, 2017 Category: Food Science Authors: Shengmin Zhou, Yueqiang Wang, Yuanrong Jiang, Zhongfei Zhang, Xiangjun Sun, Liangli (Lucy) Yu Tags: Health, Nutrition, & Food Source Type: research
Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis
Conclusions: While inulin, and perhaps other fermentable fibers, can ameliorate low-grade inflammation and associated metabolic disease, it also has the potential to exacerbate disease severity in response to inducers of acute colitis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
A low-fat diet enriched in fish oil increased lipogenesis and fetal outcome of C57BL/6 mice
There is clear evidence that nutritional strategy employed during pregnancy has profound influence on the offspring health outcomes. However, the effect of the quality and the quantity of maternal fat intake on maternal metabolic profile during different stages of pregnancy and its impact on pregnancy sustainability is not known. Female C57BL/6 mice (7 weeks old) were fed diets varying in the quantity of fat (5% vs 11%) for two weeks prior to mating and throughout pregnancy. The 5% fat diet was enriched with longer chain omega (n)-3 polyunsaturated fatty acids (PUFA) from fish oil. Maternal plasma and tissues were collecte...
Source: Reproduction - June 17, 2017 Category: Reproduction Medicine Authors: Akerele, O. A., Cheema, S. K. Tags: Research Source Type: research
Substitutions of dairy product intake and risk of stroke: a Danish cohort study
AbstractLow fat dairy products are part of dietary guidelines to prevent stroke. However, epidemiological evidence is inconclusive with regard to the association between dairy products and stroke. We therefore investigated associations for substitutions between dairy product subgroups and risk of total stroke and stroke subtypes. We included 55,211 Danish men and women aged 50 –64 years without previous stroke. Baseline diet was assessed by a food frequency questionnaire. Cases were identified through a national register and subsequently verified. The associations were analyzed using Cox proportional hazard regression. ...
Source: European Journal of Epidemiology - June 12, 2017 Category: Epidemiology Source Type: research
Comparison of efficacy of low ‐carbohydrate and low‐fat diet education program in non‐alcoholic fatty liver disease; Randomized controlled study.
ConclusionsLow‐carbohydrate diet program is more realistic and effective in reducing total energy intake and hepatic fat contents in Korean NAFLD patients. (Source: Hepatology Research)
Source: Hepatology Research - June 7, 2017 Category: Internal Medicine Authors: Eun Chul Jang, Dae Won Jun, Seung Min Lee, Yong kyun. Cho, Sang Bong Ahn Tags: Original Article Source Type: research
Statin prescription strategies and atherogenic cholesterol goals attainment in Lebanese coronary artery disease patients
Conclusion Improvement of statin prescription strategies, such as using regular and scheduled dosage of high-intensity statins and combining statin therapy with ezetimibe, is therefore required when managing patients with CAD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 18, 2017 Category: Drugs & Pharmacology Source Type: research
Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy
Publication date: 23 June 2017 Source:Neuroscience, Volume 354 Author(s): Lucia Buccarello, Giuliano Grignaschi, Alessia Di Giancamillo, Cinzia Domeneghini, Roberto Cosimo Melcangi, Tiziana Borsello Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain. Although numerous studies in mouse models of Alzheimer disease (AD) have shown a correlation among diet, beta-amyloid and AD onset, little is known about the impact of diet on Tau. We investigated whether a low fat-protein diet (LFPD) may improve lifespan, cognitive and locomotor activity...
Source: Neuroscience - May 18, 2017 Category: Neuroscience Source Type: research
Low-fat dietary pattern and cardiovascular disease: results from the Women's Health Initiative randomized controlled trial.
Conclusions: CVD risk in postmenopausal women appears to be sensitive to a change to a low-fat dietary pattern and, among healthy women, includes both CHD benefit and stroke risk. This trial was registered at clinicaltrials.gov as NCT00000611.
PMID: 28515068 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - May 17, 2017 Category: Nutrition Authors: Prentice RL, Aragaki AK, Van Horn L, Thomson CA, Beresford SA, Robinson J, Snetselaar L, Anderson GL, Manson JE, Allison MA, Rossouw JE, Howard BV Tags: Am J Clin Nutr Source Type: research
Evaluation of diet pattern and weight gain in postmenopausal women enrolled in the Women's Health Initiative Observational Study.
Abstract
It is unclear which of four popular contemporary diet patterns is best for weight maintenance among postmenopausal women. Four dietary patterns were characterised among postmenopausal women aged 49-81 years (mean 63·6 (sd 7·4) years) from the Women's Health Initiative Observational Study: (1) a low-fat diet; (2) a reduced-carbohydrate diet; (3) a Mediterranean-style (Med) diet; and (4) a diet consistent with the US Department of Agriculture's Dietary Guidelines for Americans (DGA). Discrete-time hazards models were used to compare the risk of weight gain (≥10 %) among high adherers of each die...
Source: The British Journal of Nutrition - May 16, 2017 Category: Nutrition Authors: Ford C, Chang S, Vitolins MZ, Fenton JI, Howard BV, Rhee JJ, Stefanick M, Chen B, Snetselaar L, Urrutia R, Frazier-Wood AC Tags: Br J Nutr Source Type: research
Outcome of a Step-Up Treatment Strategy for Chyle Leakage After Esophagectomy
Conclusions A step-up treatment strategy, starting with dietary modifications, solved nearly 90% of chyle leaks conservatively. A minority of chyle leaks required surgery. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - May 16, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research
Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice.
CONCLUSIONS: These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.
PMID: 28500829 [PubMed - in process] (Source: Hormones)
Source: Hormones - May 15, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Outcome of a Step-Up Treatment Strategy for Chyle Leakage After Esophagectomy.
CONCLUSIONS: A step-up treatment strategy, starting with dietary modifications, solved nearly 90% of chyle leaks conservatively. A minority of chyle leaks required surgery.
PMID: 28499656 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - May 9, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Weijs TJ, Ruurda JP, Broekhuizen ME, Bracco Gartner TCL, van Hillegersberg R Tags: Ann Thorac Surg Source Type: research
