Assessment of the Cutaneous Hormone Landscapes and Microbiomes in Vulvar Lichen Sclerosus
Vulvar lichen sclerosus (VLS) is a progressive skin disease of unknown etiology. In this longitudinal case-control exploratory study, we evaluated the hormonal and microbial landscapes in 18 postmenopausal women (mean [SD] age: 64.4 [8.4]) with vulvar lichen sclerosus and controls. We reevaluated the VLS patients after 10-14 weeks of daily topical Class I steroid. We found that groin cutaneous estrone was lower in vulvar lichen sclerosus versus controls ( –22.33, 95% CI –36.96 to –7.70; P = 0.006); cutaneous progesterone was higher (5.73, 95% CI 3.74 to 7.73; P (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - February 16, 2024 Category: Dermatology Authors: Hunter J. Pyle, Jessica C. Evans, Methinee Artami, Prithvi Raj, Srisha Sridharan, Carlos Arana, Kaitlyn M. Eckert, Jeffrey G. McDonald, Tamia A. Harris-Tryon, Melissa M. Mauskar Tags: Original Article Source Type: research
Lichen Sclerosus of the Labial Mucosa: A Case Report and Literature Review
We report a case of a 58-year-old female referred from the otolaryngology department for evaluating an asymptomatic whitish sclerotic plaque on the lower lip mucosa that had existed for 1 year. Following a punch biopsy, the patient was diagnosed with LS of labial mucosa. The condition improved after 2 months of treatment with topical and intralesional corticosteroids. The present case report raises awareness in recognizing oral LS and contributes to knowledge of this rare disorder.PMID:38318493 | PMC:PMC10840517 | DOI:10.2147/CCID.S448367 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2024 Category: Dermatology Authors: Koramon Phuwaraks Suthinee Rutnin Poonkiat Suchonwanit Source Type: research
Hybrid cooperative complexes to decrease VAS score and enhance sexual function in women with vulvar lichen sclerosus
CONCLUSIONS: Overall, this preliminary study demonstrated the promising efficacy of HCC in menopausal women with VLS without side effects.PMID:38305624 | DOI:10.26355/eurrev_202401_35082 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 2, 2024 Category: Drugs & Pharmacology Authors: M Tedesco L Alei A Bonadies T Pallara P Parisi A Latini B Bellei F Sperati E Migliano Source Type: research
Hybrid cooperative complexes to decrease VAS score and enhance sexual function in women with vulvar lichen sclerosus
CONCLUSIONS: Overall, this preliminary study demonstrated the promising efficacy of HCC in menopausal women with VLS without side effects.PMID:38305624 | DOI:10.26355/eurrev_202401_35082 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 2, 2024 Category: Drugs & Pharmacology Authors: M Tedesco L Alei A Bonadies T Pallara P Parisi A Latini B Bellei F Sperati E Migliano Source Type: research
Vulvar lichen sclerosus – Innovative hifu treatment
Introduction and aim: Vulvar lichen sclerosus is a chronic inflammatory disease of the skin and mucous membranes of the vulva. Clinical symptoms include whitening of the skin of the vulva, burning, itching, cracking of the skin. It can also be burning and itching without skin changes. The aim of the study was to evaluate the effectiveness of the HIFU method in the treatment in a patient with VLS. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Adrianna Marzec, Anita Olejek, Kamila Stopi ńska Source Type: research
