Assessment of the Cutaneous Hormone Landscapes and Microbiomes in Vulvar Lichen Sclerosus

Vulvar lichen sclerosus (VLS) is a progressive skin disease of unknown etiology. In this longitudinal case-control exploratory study, we evaluated the hormonal and microbial landscapes in 18 postmenopausal women (mean [SD] age: 64.4 [8.4]) with vulvar lichen sclerosus and controls. We reevaluated the VLS patients after 10-14 weeks of daily topical Class I steroid. We found that groin cutaneous estrone was lower in vulvar lichen sclerosus versus controls ( –22.33, 95% CI –36.96 to –7.70; P = 0.006); cutaneous progesterone was higher (5.73, 95% CI 3.74 to 7.73; P

https://www.jidonline.org/article/S0022-202X(24)00111-8/fulltext?rss=yes

Source: Journal of Investigative Dermatology - February 16, 2024 Category: Dermatology Authors: Hunter J. Pyle, Jessica C. Evans, Methinee Artami, Prithvi Raj, Srisha Sridharan, Carlos Arana, Kaitlyn M. Eckert, Jeffrey G. McDonald, Tamia A. Harris-Tryon, Melissa M. Mauskar Tags: Original Article Source Type: research