A large sample-based case-control study of related risk factors of two types of lichenoid vulvar disease (LVD)
Lichenoid vulvar dermatoses (LVD) present a kind of chronic inflammatory disease, and the most common clinical symptom of LVD is vulvar pruritus or pain. LVD include vulvar lichen sclerosus (VLS), lichen planus and vulvar lichen simplex chronicus (VLSC)[1]. Therefore, as the two most common types, VLS and VLSC are important part of LVD in clinic. Studies have shown that these VLS and VLSC are similar in histopathology, disease progression, clinical manifestation and natural outcome[2]. However, VLS and VLSC have their own characteristic manifestations, and their differential diagnosis is of great significance for the treat...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - December 11, 2023 Category: OBGYN Authors: Dongmei Wei, Can Luo, Yueyue Chen, Jijie Li, Xiaoyu Niu Tags: Full length article Source Type: research
The Novel Use of Bipolar Radiofrequency Microneedling in the Treatment of Lichen Sclerosus
CONCLUSION: Radiofrequency with microneedling treatments for persistent LS showed significant improvement in LS symptoms. As LS is a chronic recurring condition, the treatment protocol resulted in high patient satisfaction for these women who had not experienced these results in terms of amount of symptom resolution or duration of symptom resolution with prior treatments using topical steroid cream or other modalities.PMID:38038180 (Source: Surgical Technology International)
Source: Surgical Technology International - December 1, 2023 Category: Surgery Authors: Tracy A Blusewicz Katherine P Coley Robert D Moore John R Miklos Source Type: research
The vulvar microbiome in lichen sclerosus and high-grade intraepithelial lesions
ConclusionThis study is the first to examine the vulvar microbiome through metagenomic shotgun sequencing in LS and HSIL patients. Diseased vulvar skin presents a distinct signature compared to healthy vulvar skin with respect to bacterial and viral fractions of the microbiome. Key findings include the presence of papillomaviruses in LS as well as in vulvar HSIL, although LS is generally considered an HPV-independent risk factor for vulvar dysplasia. This exploratory study provides clues to the etiology of vulvar premalignancies and may act as a steppingstone for expanding the knowledge on potential drivers of disease prog...
Source: Frontiers in Microbiology - November 29, 2023 Category: Microbiology Source Type: research
Involvement of vulva in lichen sclerosus increases the risk of antidepressant and benzodiazepine prescriptions for psychiatric disorder diagnoses
International Journal of Impotence Research, Published online: 16 November 2023; doi:10.1038/s41443-023-00793-3Involvement of vulva in lichen sclerosus increases the risk of antidepressant and benzodiazepine prescriptions for psychiatric disorder diagnoses (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - November 16, 2023 Category: Urology & Nephrology Authors: Una E. Choi Ryan C. Nicholson Pranjal Agrawal Emelia Watts Taylor P. Kohn Jaden R. Kohn Marisa Clifton Source Type: research
213 Overlapping confusion: overlap of CTCL with lichen sclerosus et atrophicus and morphea
We present six cases of overlapping clinical presentation, histopathology, and treatment. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: E. Gordon, O. Adeuyan, B. Lapolla, M. Trager, C. Schreidah, L. Fahmy, L. Geskin Source Type: research
41 Photodynamic therapy using nano-encapsulated peptides in the complex treatment of anogenital lichen sclerosus
Introduction: Lichen sclerosus is an anogenital autoimmune inflammatory dermatosis,a variant of limited scleroderma.The disease manifests by unbearable anogenital itching,pain,dysuria,dyspareunia in both women and men.Photodynamic therapy are being standardized with new sensitizer containing 5-aminolevulinic acid nanopeptide complex.The complex induces protoporphyrin IX in the skin cell mitochondria.The latter releases singlet oxygen under red-light radiation that destroys collagen in the skin lesion. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: L. Shamilova, E. Snarskaya Source Type: research
Patients with vulvar lichen sclerosus prioritize education on disease etiology, triggers and treatment
J Dermatolog Treat. 2023 Oct 30;34(1):2262632. doi: 10.1080/09546634.2023.2262632. Epub 2023 Oct 31.NO ABSTRACTPMID:37905436 | DOI:10.1080/09546634.2023.2262632 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 31, 2023 Category: Dermatology Authors: Emily A Parks Mallory L Zaino Jessica N Pixley Vani Mangalam Subramanian Deepak Sirdeshmukh Steven R Feldman Rita O Pichardo Source Type: research
