Abrocitinib as a novel treatment for lichen sclerosus
Br J Dermatol. 2023 Apr 24:ljad129. doi: 10.1093/bjd/ljad129. Online ahead of print.NO ABSTRACTPMID:37093680 | DOI:10.1093/bjd/ljad129 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 24, 2023 Category: Dermatology Authors: Chengbei Bao Qiuyun Xu Zhixun Xiao Haiqing Wang Renwei Luo Bo Cheng Chao Ji Ting Gong Source Type: research
386 Association between lichen sclerosus, and atopic dermatitis: A cross-sectional study in adults with atopic dermatitis
Atopic Dermatitis (AD) is a pruritic inflammatory skin condition that frequently occurs in childhood and is also highly prevalent in adults. AD has been associated with a number of comorbid diseases including atopic and non-atopic conditions. Lichen sclerosus (LS) is a chronic, inflammatory skin disorder that can result in permanent scarring and has been previously reported to be associated with AD. However, the nature of this association has not been well characterized. The purpose of this study was to explore the association between AD and LS in patients with AD.vWe performed a single-center, retrospective chart review o...
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: V. Foy, Z. C. Chiesa Fuxench, G. Munayco Maldonado Source Type: research
500 Comorbidities in 630 male patients with lichen sclerosus: A case-control study
We studied the comorbidities in 630 male patients with lichen sclerosus (LS). The patients were diagnosed between 2004 and 2020 in Turku University Hospital, and identified either by the ICD-10 diagnosis code for lichen sclerosus (L90.0), or leukoplakia of the penis/balanitis xerotica obliterans (N48.0), or from the pathology information system. Ten age- and sex-matched controls with no diagnosis of LS were randomly selected from the hospital ’s electronic health records for each identified patient. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: N. Hieta, M. Haataja, L. Tapana Source Type: research
992 The prevalence of human papillomavirus (HPV) DNA in male genital lichen sclerosus (MGLSc)
MGLSc is an acquired, chronic skin disease that can lead to sexual dysfunction and urological morbidity. Although both MGLSc and HPV are considered risk factors for penile cancer, no clear link has been found between the two. To further investigate the possibility of an association we correlated the presence of MGLSc and HPV across the prepuce. Preputial fresh frozen samples were collected from nine patients with clinically diagnosed MGLSc. The specimens were divided into a grid and biopsies were obtained to determine the spatial distribution of MGLSc and for HPV DNA sequencing. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: G. Kravvas, C. Ganier, H. van den Munckhof, M. de Koning, W. Quint, A. Freeman, A. Haider, H. Alnajjar, A. Muneer, M. Lynch, C. Bunker Source Type: research
1044 Transcriptionally active human papillomavirus (HPV) in male genital lichen sclerosus (MGLSc), penile intraepithelial neoplasia (PeIN), and penile squamous cell carcinoma (PeSCC)
Although HPV infection is clearly implicated in the pathogenesis of undifferentiated PeIN and PeSCC, the role of HPV in MGLSc and differentiated PeIN remains unclear. Whilst the prevalence of HPV in MGLSc in most studies is reported as ≥20%, this number largely reflects HPV latency and not transcriptional activity. Formalin-fixed, paraffin-embedded blocks of penile tissue from 94 patients with MGLSc, PeSCC, differentiated (MGLSc-related) and undifferentiated (HPV-related) PeIN, as well as disease-adjacent unaffected penile skin were used to create microarrays. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: G. Kravvas, B. Xie, C. Thrasivoulou, M. Millar, A. Freeman, A. Haider, H. Alnajjar, A. Muneer, M. Lynch, C. Bunker Source Type: research
1614 A systematic review and meta-analysis of comorbidities in lichen sclerosus with a screening recommendation
Lichen sclerosus (LS) may be associated with various diseases. Differences in the occurrence of comorbidities between men and women with LS are assumed, but have not been analyzed in detail. The purpose of the study was to identify the influence of gender on the prevalence of comorbidities amongst individuals with and without LS and to suggest their screening strategy in LS. This systematic review of case-control studies was registered in PROSPERO (registration number CRD42022333520) and was performed according to the PRISMA guidelines. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: S. Suler Baglama, G.B. Jemec, K. Tr čko Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Mar 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Mar 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Apr 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Apr 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Apr 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Apr 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
A comparative study of two single-stage oral mucosal substitution urethroplasty (Kulkarni and Asopa) in the surgical treatments of lichen sclerosus urethral strictures
Asian J Androl. 2023 Apr 7. doi: 10.4103/aja20236. Online ahead of print.ABSTRACTLong-segment lichen sclerosus (LS) urethral stricture is a challenge for urologists. Limited data are available for surgeons to make a surgical decision between Kulkarni and Asopa urethroplasty. In this retrospective study, we investigated the outcomes of these two procedures in patients with LS urethral stricture. Between January 2015 and December 2020, 77 patients with LS urethral stricture underwent Kulkarni and Asopa procedures for urethroplasty in the Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University S...
Source: Asian Journal of Andrology - April 11, 2023 Category: Urology & Nephrology Authors: Xiang Wan Hai-Jun Yao Min-Kai Xie Jian-Shu Ni Da-Jun Gao Zhong Wang Bin Xu Da-Chao Zheng Source Type: research
The efficacy and safety of 5-aminolevulinic acid photodynamic therapy for lichen sclerosus: A meta analysis
Conclusions: The current limited evidence supports the efficacy and safety of ALA-PDT in treating LS. The adverse reactions included pain, swelling, redness and exfoliation which would decrease with the continuing sessions of treatment. Further high-qualified RCTs of large samples are necessarily needed. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 31, 2023 Category: Dermatology Authors: Chun Qing Xiaoyong Mao Gaoqing Liu Yibin Deng Xiaokun Yang Source Type: research
A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study
CONCLUSION: In this study, we were able to compare multiple variables between 47 circumcised patients diagnosed with LSc and a control group. We found that LSc patients showed higher rates of diabetes and hypertension. A potential protective effect of alcohol consumption is to be explored in future projects with bigger sample sizes and higher statistical powers.PMID:36970324 | PMC:PMC10033206 | DOI:10.1155/2023/7208312 (Source: Advances in Urology)
Source: Advances in Urology - March 27, 2023 Category: Urology & Nephrology Authors: Joey El Khoury Jessica Andraos Anthony Kanbar Rami Halabi Serge Assaf Anthony Mina Sabine El Breidi Charbel Dabal Charbel El Hachem Rodrigue Saad Antoine Kassis Maher Abdessater Raghid El Khoury Source Type: research
