41 Photodynamic therapy using nano-encapsulated peptides in the complex treatment of anogenital lichen sclerosus

Introduction: Lichen sclerosus is an anogenital autoimmune inflammatory dermatosis,a variant of limited scleroderma.The disease manifests by unbearable anogenital itching,pain,dysuria,dyspareunia in both women and men.Photodynamic therapy are being standardized with new sensitizer containing 5-aminolevulinic acid nanopeptide complex.The complex induces protoporphyrin IX in the skin cell mitochondria.The latter releases singlet oxygen under red-light radiation that destroys collagen in the skin lesion.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research