Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy
This study suggests that uEVs contain bioactive components capable of inducing protective, anti-inflammatory, anti-fibrinolytic, and antioxidative effects in renal cells. These findings contribute to our understanding of uEVs' role in renal compensatory mechanisms after unilateral nephrectomy and may hold promise for future therapeutic interventions in renal diseases.PMID:38499276 | DOI:10.1016/j.bbadis.2024.167096 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 18, 2024 Category: Biochemistry Authors: Rasha Aly Sara Darwish Niharika Bala Areej Ebrahim Lawrence R Shoemaker Joel McCray Timothy J Garrett Abdel A Alli Source Type: research
Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy
This study suggests that uEVs contain bioactive components capable of inducing protective, anti-inflammatory, anti-fibrinolytic, and antioxidative effects in renal cells. These findings contribute to our understanding of uEVs' role in renal compensatory mechanisms after unilateral nephrectomy and may hold promise for future therapeutic interventions in renal diseases.PMID:38499276 | DOI:10.1016/j.bbadis.2024.167096 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 18, 2024 Category: Biochemistry Authors: Rasha Aly Sara Darwish Niharika Bala Areej Ebrahim Lawrence R Shoemaker Joel McCray Timothy J Garrett Abdel A Alli Source Type: research
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Exp Neurol. 2024 Mar 15:114754. doi: 10.1016/j.expneurol.2024.114754. Online ahead of print.ABSTRACTSpasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI) and currently lacks adequate treatment options. This sensorimotor condition is burdensome as hyperexcitability of reflex pathways result in exacerbated reflex responses, co-contractions of antagonistic muscles, and involuntary movements. Transcutaneous spinal cord stimulation (tSCS) has become a popular tool in the human SCI research field. The likeliness for this intervention to be successful as a nonin...
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Dillon C Malloy Marie-Pascale C ôté Source Type: research
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Exp Neurol. 2024 Mar 15:114754. doi: 10.1016/j.expneurol.2024.114754. Online ahead of print.ABSTRACTSpasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI) and currently lacks adequate treatment options. This sensorimotor condition is burdensome as hyperexcitability of reflex pathways result in exacerbated reflex responses, co-contractions of antagonistic muscles, and involuntary movements. Transcutaneous spinal cord stimulation (tSCS) has become a popular tool in the human SCI research field. The likeliness for this intervention to be successful as a nonin...
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Dillon C Malloy Marie-Pascale C ôté Source Type: research
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Exp Neurol. 2024 Mar 15:114754. doi: 10.1016/j.expneurol.2024.114754. Online ahead of print.ABSTRACTSpasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI) and currently lacks adequate treatment options. This sensorimotor condition is burdensome as hyperexcitability of reflex pathways result in exacerbated reflex responses, co-contractions of antagonistic muscles, and involuntary movements. Transcutaneous spinal cord stimulation (tSCS) has become a popular tool in the human SCI research field. The likeliness for this intervention to be successful as a nonin...
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Dillon C Malloy Marie-Pascale C ôté Source Type: research
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Exp Neurol. 2024 Mar 15:114754. doi: 10.1016/j.expneurol.2024.114754. Online ahead of print.ABSTRACTSpasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI) and currently lacks adequate treatment options. This sensorimotor condition is burdensome as hyperexcitability of reflex pathways result in exacerbated reflex responses, co-contractions of antagonistic muscles, and involuntary movements. Transcutaneous spinal cord stimulation (tSCS) has become a popular tool in the human SCI research field. The likeliness for this intervention to be successful as a nonin...
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Dillon C Malloy Marie-Pascale C ôté Source Type: research
Extrusion 3D-printed tricalcium phosphate-polycaprolactone biocomposites for quercetin-KCl delivery in bone tissue engineering
This study provides valuable insights as a promising strategy for bone tissue engineering (BTE) in orthopedic repair.PMID:38477071 | DOI:10.1002/jbm.a.37692 (Source: Cell Research)
Source: Cell Research - March 13, 2024 Category: Cytology Authors: Connor Toulou Vishal Sharad Chaudhari Susmita Bose Source Type: research
Extrusion 3D-printed tricalcium phosphate-polycaprolactone biocomposites for quercetin-KCl delivery in bone tissue engineering
This study provides valuable insights as a promising strategy for bone tissue engineering (BTE) in orthopedic repair.PMID:38477071 | DOI:10.1002/jbm.a.37692 (Source: Biomed Res)
Source: Biomed Res - March 13, 2024 Category: Research Authors: Connor Toulou Vishal Sharad Chaudhari Susmita Bose Source Type: research
Extrusion 3D-printed tricalcium phosphate-polycaprolactone biocomposites for quercetin-KCl delivery in bone tissue engineering
This study provides valuable insights as a promising strategy for bone tissue engineering (BTE) in orthopedic repair.PMID:38477071 | DOI:10.1002/jbm.a.37692 (Source: Biomed Res)
Source: Biomed Res - March 13, 2024 Category: Research Authors: Connor Toulou Vishal Sharad Chaudhari Susmita Bose Source Type: research
Reticular abscess in buffaloes and cattle: clinical-biochemical, diagnostic imaging findings, treatment and long-term follow-up
This study aims to describe clinical features, hemato-biochemical alterations, management, productive and reproductive performance, long term follow-up of reticular abscess in bovines. This prospective study was conducted on 12 bovines diagnosed with reticular abscess. All the animals were subjected to hematological and biochemical evaluation along with a healthy control group. The diseased animals were subjected to radiography, ultrasonography, and surgical treatment. The clinical findings were chronic anorexia, dehydration, persistent or recurrent tympany, scanty feces, mushy rumen, tachypnea, gradual reduction in milk y...
Source: Comparative Clinical Pathology - March 7, 2024 Category: Pathology Source Type: research
Azathioprine and hydroxychloroquine overdose in Sj ögren’s syndrome patient with hypocalcemia: a case report
ConclusionHydroxychloroquine and azathioprine toxicity are considered rare, but it is likely to increase in frequency given the prevalence and increase in autoimmune diseases and the increasing usage of these drugs in treating such diseases. We found hypocalcemia as the presentation to this patient, which needs further investigation into the probable mechanism. Clinicians need to consider the unique effects of hydroxychloroquine and azathioprine poisoning and initiate appropriate emergency interventions to improve the outcomes in similar patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 27, 2024 Category: General Medicine Source Type: research
In-vitro and preclinical testing of < em > bacillus subtilis < /em > UBBS-14 probiotic in rats shows no toxicity
CONCLUSION: B. subtilis UBBS-14's no-observed-effect level (NOEL) was thus determined to be >1,000 mg/kg bw/day following a 28-day oral dosing.PMID:38406637 | PMC:PMC10891425 | DOI:10.1093/toxres/tfae021 (Source: Cell Research)
Source: Cell Research - February 26, 2024 Category: Cytology Authors: Ankit Negi Tulasi Pasam Syed Muhammad Farqadain Y Mahalaxmi Manoj P Dandekar Source Type: research
A LC-MS/MS method for the simultaneous quantification of 17 opioids in biosolids
Talanta. 2024 Feb 8;272:125775. doi: 10.1016/j.talanta.2024.125775. Online ahead of print.ABSTRACTThe solid product of wastewater treatment plants is commonly used as a fertiliser to increase sustainability and waste reuse. It has undergone extensive treatment to remove high nutrient loads, pathogens and heavy metals but the extensive matrix of household chemicals, pesticides and pharmaceuticals remains, untargeted by most treatment technologies. These compounds, particularly pharmaceuticals, have been detected in biosolids with there being evidence of uptake by plants. With the current opioid pandemic in North America and...
Source: Talanta - February 24, 2024 Category: Chemistry Authors: Jamie Simpson Bradley S Simpson Cobus Gerber Source Type: research
Ion-Induced PIP2 Clustering with Martini3: Modification of Phosphate-Ion Interactions and Comparison with CHARMM36
J Phys Chem B. 2024 Feb 23. doi: 10.1021/acs.jpcb.3c06523. Online ahead of print.ABSTRACTPhosphatidylinositol 4,5-bisphosphate (PIP2) is a critical lipid for cellular signaling. The specific phosphorylation of the inositol ring controls protein binding as well as clustering behavior. Two popular models to describe ion-mediated clustering of PIP2 are Martini3 (M3) and CHARMM36 (C36). Molecular dynamics simulations of PIP2-containing bilayers in solutions of potassium chloride, sodium chloride, and calcium chloride, and at two different resolutions are performed to understand the aggregation and the model parameters that dri...
Source: Health Physics - February 23, 2024 Category: Physics Authors: Zack Jarin Richard M Venable Kyungreem Han Richard W Pastor Source Type: research
A Review on Enhancing the Life of Teeth by Toothpaste Containing Bioactive Glass Particles
AbstractPurpose of ReviewDental caries or tooth decay is one of the communal problems in the world which can affect not only the oral health but also the general health conditions. The main objective of this systematic review is to explore the efficacy of bioactive glass-based toothpastes against cariogenic bacteria.Recent FindingsBioactive glass particulates containing toothpaste show better remineralization potential on demineralized enamel and dentin when compared with toothpaste containing various bioactive constituents such as fluoride and potassium chloride. These constituents in conventional toothpaste can rapidly s...
Source: Current Oral Health Reports - February 16, 2024 Category: Dentistry Source Type: research
