High-throughput characterization of the effect of sodium chloride and potassium chloride on 31 lactic acid bacteria and their co-cultures
In this study, we characterized the effect of sodium chloride (NaCl) and potassium chloride (KCl) on the growth and acidification of 31 LAB strains. In addition, we evaluated the effect of salts on a total of 93 random pairwise strain combinations. Strains and co-cultures were tested at 3% NaCl, 5% NaCl, and 3% KCl on solid medium using an automated approach and image analysis. The results showed that the growth of LAB was significantly reduced by up to 68% at 5% NaCl (p < 0.0001). For the co-cultures, a reduction of up to 57% was observed at 5% NaCl (p < 0.0001). However, acidification was less affected by s...
Source: Frontiers in Microbiology - February 16, 2024 Category: Microbiology Source Type: research
In-situ one-step construction of poly(heptazine imide)/poly(triazine imide) heterojunctions
ChemSusChem. 2024 Feb 5:e202301849. doi: 10.1002/cssc.202301849. Online ahead of print.ABSTRACTThe construction of heterojunctions is challenging, requiring atomic-level contact and interface matching. Here, we have achieved atomic-level interfacial matching by constructing poly(heptazine imide)/poly(triazine imide) crystalline carbon nitride heterojunctions in an in-situ one-step method. The content of poly(triazine imide) in heterojunctions is positively related to the proportion of lithium chloride in potassium chloride and lithium chloride mixed-salts. The optimized heterojunction achieves an apparent quantum efficienc...
Source: ChemSusChem - February 5, 2024 Category: Chemistry Authors: Hui Li Guoqiang Zhang Peixin Zhang Hongwei Mi Source Type: research
The Management of Nausea and Vomiting in Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No. 69)
BJOG. 2024 Feb 4. doi: 10.1111/1471-0528.17739. Online ahead of print.ABSTRACTAn objective and validated index of nausea and vomiting such as the Pregnancy-Unique Quantification of Emesis (PUQE) and HyperEmesis Level Prediction (HELP) tools can be used to classify the severity of NVP and HG. [Grade C] Ketonuria is not an indicator of dehydration and should not be used to assess severity. [Grade A] There are safety and efficacy data for first line antiemetics such as anti (H1) histamines, phenothiazines and doxylamine/pyridoxine (Xonvea®) and they should be prescribed initially when required for NVP and HG (Appendix III). ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 4, 2024 Category: OBGYN Authors: Catherine Nelson-Piercy Caitlin Dean Manjeet Shehmar Roger Gadsby Margaret O'Hara Kenneth Hodson Melanie Nana Royal College of Obstetricians and Gynaecologists Source Type: research
Partial Replacement of NaCl with KCl in Cooked Meat Could Reduce the Liver Damage Through Renin –Angiotensin System in Mice
ConclusionPartial substitution of NaCl with KCl in cooked meat can be a feasible approach for improving the health benefits and developing novel functional meat products for nutritional health interventions. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 3, 2024 Category: Food Science Authors: Lifang Zou,
Xia Yu,
Jiahao Xiong,
Conggui Chen,
Guiran Xiao Tags: Research Article Source Type: research
Sensors, Vol. 24, Pages 883: Exploring Novel Sensor Design Ideas through Concentration-Induced Conformational Changes in PEG Single Chains
In this study, the dynamic response of PEG single chains to different ion concentrations was investigated from a microscopic point of view based on single-molecule force spectroscopy, revealing unique interactions that go beyond the traditional sensor-design paradigm. Under low concentrations of potassium chloride, PEG single chains exhibit a gradual reduction in rigidity, while, conversely, high concentrations induce a progressive increase in rigidity. This dichotomy serves as the cornerstone for a profound understanding of PEG conformational dynamics under diverse ion environments. Capitalizing on the remarkable sensitiv...
Source: Sensors - January 29, 2024 Category: Biotechnology Authors: Miao Yu Chong Jiang Bing Lai Kai Zhang Tags: Article Source Type: research
Tempol treatment normalizes membrane expression of epithelial transport proteins in the kidney of salt-loaded hypertensive diabetic db/db mice
CONCLUSIONS: This study demonstrates that tempol down-regulates epithelial transport mechanisms in each segment of the nephron and normalizes salt-induced high blood pressure in diabetic animals presumably in a PKC dependent manner.PMID:38186979 | PMC:PMC10767517 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 8, 2024 Category: Research Authors: Yunus E Dogan Niharika Bala Kevin M Chacko Kubra M Tuna Abdel A Alli Source Type: research
A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient formulations at 75°C for 3 days before characterization. Differentiating itself from other excipient compatibility methods, our methodology necessitates a saturated aqueous slurry rather than arbitrarily fixed water content. This allows bulk and surface water in the excipient to contribute to drug degradation. The synergistic impact of surface water and elevated temperature expedites degradation kinetics, resulting in accelerated data generation. Among excipient compatibility methods...
Source: AAPS PharmSciTech - January 5, 2024 Category: Drugs & Pharmacology Authors: Amol S Matharu Sundeep S Dhareshwar Yu Jade Cao Source Type: research
A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient formulations at 75°C for 3 days before characterization. Differentiating itself from other excipient compatibility methods, our methodology necessitates a saturated aqueous slurry rather than arbitrarily fixed water content. This allows bulk and surface water in the excipient to contribute to drug degradation. The synergistic impact of surface water and elevated temperature expedites degradation kinetics, resulting in accelerated data generation. Among excipient compatibility methods...
Source: AAPS PharmSciTech - January 5, 2024 Category: Drugs & Pharmacology Authors: Amol S Matharu Sundeep S Dhareshwar Yu Jade Cao Source Type: research
A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient formulations at 75°C for 3 days before characterization. Differentiating itself from other excipient compatibility methods, our methodology necessitates a saturated aqueous slurry rather than arbitrarily fixed water content. This allows bulk and surface water in the excipient to contribute to drug degradation. The synergistic impact of surface water and elevated temperature expedites degradation kinetics, resulting in accelerated data generation. Among excipient compatibility methods...
Source: AAPS PharmSciTech - January 5, 2024 Category: Drugs & Pharmacology Authors: Amol S Matharu Sundeep S Dhareshwar Yu Jade Cao Source Type: research
Magnetic Resonance Imaging Combined with Histological Techniques for Dynamic Assessment of Cytotoxic Edema after Cerebral Ischemia-Reperfusion Injury
CONCLUSIONS: MRI combined with histological techniques can dynamically assess cytotoxic edema after CIRI, in a manner that is clear and intuitive for scientific researchers and clinicians, and provides a scientific basis for the application of MRI techniques for monitoring the dynamic progress of CIRI.PMID:38176948 | DOI:10.31083/j.jin2206162 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Yuhui Ma Peilun Xiao Chenmeng Liu Haimo Zhang Zhen Li Chen Li Miao Yu Jinfeng Long Lin An Xizhen Wang Xiaoli Wang Source Type: research
Magnetic Resonance Imaging Combined with Histological Techniques for Dynamic Assessment of Cytotoxic Edema after Cerebral Ischemia-Reperfusion Injury
CONCLUSIONS: MRI combined with histological techniques can dynamically assess cytotoxic edema after CIRI, in a manner that is clear and intuitive for scientific researchers and clinicians, and provides a scientific basis for the application of MRI techniques for monitoring the dynamic progress of CIRI.PMID:38176948 | DOI:10.31083/j.jin2206162 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Yuhui Ma Peilun Xiao Chenmeng Liu Haimo Zhang Zhen Li Chen Li Miao Yu Jinfeng Long Lin An Xizhen Wang Xiaoli Wang Source Type: research
Magnetic Resonance Imaging Combined with Histological Techniques for Dynamic Assessment of Cytotoxic Edema after Cerebral Ischemia-Reperfusion Injury
CONCLUSIONS: MRI combined with histological techniques can dynamically assess cytotoxic edema after CIRI, in a manner that is clear and intuitive for scientific researchers and clinicians, and provides a scientific basis for the application of MRI techniques for monitoring the dynamic progress of CIRI.PMID:38176948 | DOI:10.31083/j.jin2206162 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Yuhui Ma Peilun Xiao Chenmeng Liu Haimo Zhang Zhen Li Chen Li Miao Yu Jinfeng Long Lin An Xizhen Wang Xiaoli Wang Source Type: research
Magnetic Resonance Imaging Combined with Histological Techniques for Dynamic Assessment of Cytotoxic Edema after Cerebral Ischemia-Reperfusion Injury
CONCLUSIONS: MRI combined with histological techniques can dynamically assess cytotoxic edema after CIRI, in a manner that is clear and intuitive for scientific researchers and clinicians, and provides a scientific basis for the application of MRI techniques for monitoring the dynamic progress of CIRI.PMID:38176948 | DOI:10.31083/j.jin2206162 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Yuhui Ma Peilun Xiao Chenmeng Liu Haimo Zhang Zhen Li Chen Li Miao Yu Jinfeng Long Lin An Xizhen Wang Xiaoli Wang Source Type: research
Magnetic Resonance Imaging Combined with Histological Techniques for Dynamic Assessment of Cytotoxic Edema after Cerebral Ischemia-Reperfusion Injury
CONCLUSIONS: MRI combined with histological techniques can dynamically assess cytotoxic edema after CIRI, in a manner that is clear and intuitive for scientific researchers and clinicians, and provides a scientific basis for the application of MRI techniques for monitoring the dynamic progress of CIRI.PMID:38176948 | DOI:10.31083/j.jin2206162 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Yuhui Ma Peilun Xiao Chenmeng Liu Haimo Zhang Zhen Li Chen Li Miao Yu Jinfeng Long Lin An Xizhen Wang Xiaoli Wang Source Type: research
