Functional and metabolomic analysis of urinary extracellular vesicles from juvenile mice with renal compensatory hypertrophy

This study suggests that uEVs contain bioactive components capable of inducing protective, anti-inflammatory, anti-fibrinolytic, and antioxidative effects in renal cells. These findings contribute to our understanding of uEVs' role in renal compensatory mechanisms after unilateral nephrectomy and may hold promise for future therapeutic interventions in renal diseases.PMID:38499276 | DOI:10.1016/j.bbadis.2024.167096

Source: Biochimica et Biophysica Acta - March 18, 2024 Category: Biochemistry Authors: Rasha Aly Sara Darwish Niharika Bala Areej Ebrahim Lawrence R Shoemaker Joel McCray Timothy J Garrett Abdel A Alli Source Type: research