Kleine-Levin syndrome: clues to aetiology
AbstractKleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1 –2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Fun ctional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the...
Source: Sleep and Breathing - March 12, 2018 Category: Respiratory Medicine Source Type: research
Kleine-Levin syndrome: clues to aetiology.
Abstract
Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1-2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the deve...
Source: Sleep and Breathing - March 12, 2018 Category: Sleep Medicine Authors: AlShareef SM, Smith RM, BaHammam AS Tags: Sleep Breath Source Type: research
The clinical characteristics of Kleine –Levin syndrome according to ethnicity and geographic location
Volume 128, Issue 9, September 2018, Page 842-848 . (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - February 21, 2018 Category: Neuroscience Authors: Saad M. Al Shareef Aljohara S. Almeneessier Richard M. Smith Ahmed S. BaHammam Source Type: research
The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome.
Conclusions: Sleep architecture of our cohort was relatively normal and broadly similar to other published studies, the main features being low sleep efficiency and low relative amounts of REM and stage N3 sleep. Time-course polysomnography studies with functional imaging may be useful to further establish the exact pathophysiology of this disease.
PMID: 29332107 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - January 16, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research
Putative mechanisms of action and clinical use of lithium in children and adolescents: a critical review.
CONCLUSIONS: Lithium seems an effective and well-tolerated medication on pediatric bipolar disorder and aggression, while further evidences are needed for other clinical indications.
PMID: 29256353 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 19, 2017 Category: Drugs & Pharmacology Authors: Pisano S, Pozzi M, Catone G, Scrinzi G, Clementi E, Coppola G, Milone A, Bravaccio C, Santosh P, Masi G Tags: Curr Neuropharmacol Source Type: research
Kleine Levin syndrome of the Pampas: review of diagnosed cases in Buenos Aires
Introduction: Kleine-Levin syndrome is an uncommon disorder with recurrent episodes of hypersomnia, associated with behavioral abnormalities like binge eating, hypersexuality and abnormal behavior. We aim to report the first cases of the Kleine-Levin syndrome in Buenos Aires, Argentina. (Source: Sleep Medicine)
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: S. Valiensi, A. Garay, O. Martinez, C. Podest á, M.E. Mazzola, C. Paleka Tags: Excessive Daytime Sleepiness (not Narcolepsy) Source Type: research
Cluster headache associated with Kleine-Levin syndrome in a young male patient
Here is reported a 18 years old male patient admitted with a complaint of long lasting sleeping periods together with masturbation episodes. His complaint began when he was 13 years old with nearly 10 days lasting sleeping period. Three weeks before first attack, he had periorbital headache that is associated with lacrimation, rhinorhea and redness in his eye. The headache continued prior to in his first 4 sleeping attacks and then disappeared. At the beginning, his 2 sleeping episodes characterized by sleeping lasting nearly 10 days associated with masturbation. (Source: Sleep Medicine)
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: Z. Pelin, M. Yuksel Tags: Excessive Daytime Sleepiness (not Narcolepsy) Source Type: research
Polysomnography, multiple sleep latency test and electroencephalography activity in Kleine-Levin syndrome
Introduction: Kleine-Levin syndrome is included in the group of Central Disorders of Hypersomnolence in the International Classification of Sleep Disorders (ICSD-3). It has been historically defined as a severe recurrent hypersomnia that also associates hyperphagia and hypersexuality. However, symptoms such as apathy or derealization in these patients are increasingly described instead of hyperphagia and hypersexuality. Actually, there are no criteria that define typical polysomnographic or EEG characteristics in this group of patients. (Source: Sleep Medicine)
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: C. Gutierrez Mu ñoz, M. Aguilar Andujar, L. Carranza Amores, L. Dinca Avarvarei, C. Menendez de Leon Tags: Excessive Daytime Sleepiness (not Narcolepsy) Source Type: research
[Kleine-Levin syndrome: immunogenetic hypothesis].
PMID: 28896006 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - September 13, 2017 Category: Neurology Authors: Peraita-Adrados R Tags: Rev Neurol Source Type: research
[A young boy with periodic strange behavior and hypersomnia: Kleine-Levin syndrome].
We present the case of an 11-year-old boy in whom the psychiatric symptoms were initially the most prominent ones.
PMID: 28880359 [PubMed - in process] (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 9, 2017 Category: Psychiatry Authors: Dauwe F, Imeraj L, Dhondt K Tags: Tijdschr Psychiatr Source Type: research
Kleine –Levin syndrome elicited by encephalopathy with reversible splenial lesion
We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5–10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine–...
Source: Pediatrics International - August 13, 2017 Category: Pediatrics Authors: Masaru Takayanagi, Shinichi Okabe, Katsuya Yamamoto, Juri Komatsu, Rikio Suzuki, Taro Kitamura, Toshihiro Ohura Tags: Patient Report Source Type: research
Narcolepsy and Other Central Hypersomnias
This article focuses on the clinical presentation, pathophysiology, diagnosis, differential diagnosis, and management of narcolepsy type 1 and narcolepsy type 2, idiopathic hypersomnia, Kleine-Levin syndrome, and other central disorders of hypersomnolence, as defined in the International Classification of Sleep Disorders, Third Edition (ICSD-3).
Recent Findings: In ICSD-3, the names of some central disorders of hypersomnolence have been changed: narcolepsy with cataplexy and narcolepsy without cataplexy have been renamed narcolepsy type 1 and narcolepsy type 2, respectively. A low level of hypocretin-1/orexin-A in the CSF...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2017 Category: Neurology Tags: Review Articles Source Type: research
Kleine & #8211;Levin syndrome: A neurological rarity
Samhita PandaNeurology India 2017 65(4):873-878 (Source: Neurology India)
Source: Neurology India - July 5, 2017 Category: Neurology Authors: Samhita Panda Source Type: research
Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents.
Case Report
Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research
