Kleine-Levin syndrome: clues to aetiology

AbstractKleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1 –2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Fun ctional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected. An autoimmune aetiology is consistent with the a vailable data. In this review, we argue that, in order to further our understanding of KLS, there needs to be a co-ordinated international effort to standardise approaches to functional imaging studies, genetic analyses that specifically address the possibility of an autoimmune aetiology, and clinic al trials of immunosuppressive therapies.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research