Kleine-Levin syndrome: clues to aetiology.

Kleine-Levin syndrome: clues to aetiology.
Sleep Breath. 2018 Mar 12;:
Authors: AlShareef SM, Smith RM, BaHammam AS
Abstract
Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1-2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected. An autoimmune aetiology is consistent with the available data. In this review, we argue that, in order to further our understanding of KLS, there needs to be a co-ordinated international effort to standardise approaches to functional imaging studies, genetic analyses that specifically address the possibility of an autoimmune aetiology, and clinical trials of immunosuppressive therapies.
PMID: 29532411 [PubMed - as supplied by publisher]

Source: Sleep and Breathing - March 12, 2018 Category: Sleep Medicine Authors: AlShareef SM, Smith RM, BaHammam AS Tags: Sleep Breath Source Type: research