A "Sleeping Beauty" With a "Heart-Hand": Kleine-Levin Syndrome Treated With Buproprion and Carbamazepine in a Patient With Holt-Oram Syndrome.
PMID: 27090505 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 17, 2016 Category: Neuroscience Authors: Gama Marques J, Faro Viana P, Peralta AR Tags: Clin EEG Neurosci Source Type: research
Kleine-Levin Syndrome
Opinion statement
Kleine-Levin Syndrome [KLS] is often under-recognized and also misdiagnosed. When suspicion for KLS is raised, a thorough clinical evaluation should be performed, including detailed history from family members and a neurologic and psychiatric examination. Additional studies may include PSG, EEG, neuroimaging, as well as serological and CSF studies to rule out alternative diagnoses as clinically indicated. After arriving at a diagnosis of KLS, the foundation of care is supportive. Patients and their families should be provided with education about the disease. During symptomatic periods...
Source: Current Treatment Options in Neurology - April 12, 2016 Category: Neurology Source Type: research
Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome
Conclusions:There are lower orexin A levels in the symptomatic phase than in remission and a fall and rise in blood pressure and heart rate, suggesting a role for orexin dysregulation in KLS pathophysiology.Citation:Wang JY, Han F, Dong SX, Li J, An P, Zhang XZ, Chang Y, Zhao L, Zhang XL, Liu YN, Yan H, Li QH, Hu Y, Lv CJ, Gao ZC, Strohl KP. Cerebrospinal fluid orexin A levels and autonomic function in Kleine-Levin syndrome. SLEEP 2016;39(4):855–860. (Source: Sleep)
Source: Sleep - April 1, 2016 Category: Sleep Medicine Source Type: research
