Genetics and epigenetics of rare hypersomnia
Trends Genet. 2023 Feb 24:S0168-9525(23)00027-6. doi: 10.1016/j.tig.2023.02.003. Online ahead of print.ABSTRACTHerein we focus on connections between genetics and some central disorders of hypersomnolence - narcolepsy types 1 and 2 (NT1, NT2), idiopathic hypersomnia (IH), and Kleine-Levin syndrome (KLS) - for a better understanding of their etiopathogenetic mechanisms and a better diagnostic and therapeutic definition. Gene pleiotropism influences neurological and sleep disorders such as hypersomnia; therefore, genetics allows us to uncover common pathways to different pathologies, with potential new therapeutic perspectiv...
Source: Trends in Genetics : TIG - February 26, 2023 Category: Genetics & Stem Cells Authors: Maria Paola Mogavero Lourdes M DelRosso Oliviero Bruni Michele Salemi Maria Salsone Fabiana Novellino Marco Zucconi Luigi Ferini Strambi Raffaele Ferri Source Type: research

Genetics and epigenetics of rare hypersomnia
Trends Genet. 2023 Feb 24:S0168-9525(23)00027-6. doi: 10.1016/j.tig.2023.02.003. Online ahead of print.ABSTRACTHerein we focus on connections between genetics and some central disorders of hypersomnolence - narcolepsy types 1 and 2 (NT1, NT2), idiopathic hypersomnia (IH), and Kleine-Levin syndrome (KLS) - for a better understanding of their etiopathogenetic mechanisms and a better diagnostic and therapeutic definition. Gene pleiotropism influences neurological and sleep disorders such as hypersomnia; therefore, genetics allows us to uncover common pathways to different pathologies, with potential new therapeutic perspectiv...
Source: Trends in Genetics : TIG - February 26, 2023 Category: Genetics & Stem Cells Authors: Maria Paola Mogavero Lourdes M DelRosso Oliviero Bruni Michele Salemi Maria Salsone Fabiana Novellino Marco Zucconi Luigi Ferini Strambi Raffaele Ferri Source Type: research

Genetics and epigenetics of rare hypersomnia
Trends Genet. 2023 Feb 24:S0168-9525(23)00027-6. doi: 10.1016/j.tig.2023.02.003. Online ahead of print.ABSTRACTHerein we focus on connections between genetics and some central disorders of hypersomnolence - narcolepsy types 1 and 2 (NT1, NT2), idiopathic hypersomnia (IH), and Kleine-Levin syndrome (KLS) - for a better understanding of their etiopathogenetic mechanisms and a better diagnostic and therapeutic definition. Gene pleiotropism influences neurological and sleep disorders such as hypersomnia; therefore, genetics allows us to uncover common pathways to different pathologies, with potential new therapeutic perspectiv...
Source: Trends in Genetics : TIG - February 26, 2023 Category: Genetics & Stem Cells Authors: Maria Paola Mogavero Lourdes M DelRosso Oliviero Bruni Michele Salemi Maria Salsone Fabiana Novellino Marco Zucconi Luigi Ferini Strambi Raffaele Ferri Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research

Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19
Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29.ABSTRACTSleep is important for the well-being of school-aged children. Almost all schools in Hyogo prefecture in Japan were closed from April 7 to May 31, 2020, owing to the coronavirus disease 2019 pandemic. The pandemic restrictions resulted in the disruption of the sleep routines of children. The number of children who experienced sleepiness in class after school closure increased. The number of children who visited our hospital 1 year before and after the closure was 208 (11.73 ± 3.24 years of age) and 155 (11.45 ± 3.30 years), respectively. The number of chief complaints of ...
Source: Kobe J Med Sci - January 16, 2023 Category: General Medicine Authors: Shigemi Kimura Yutaka Takaoka Aki Sugano Source Type: research