Agreement Between Swept-source Optical Coherence Tomography and Rotating Scheimpflug Camera in Measurement of Corneal Parameters in Normal and Keratoconic Eyes
CONCLUSION: Although the devices had different mean indices values, they had a good agreement based on the Bland-Altman plots. Since Pentacam is accepted as the standard tool for diagnosing ectatic cornea, pentacam CASIA2 is also helpful for early diagnosis of KCN.PMID:38250237 | PMC:PMC10794808 | DOI:10.18502/jovr.v18i4.14547 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - January 22, 2024 Category: Opthalmology Authors: Hamed Ghassemi Mehran Zarei-Ghanavati Mina Khastavan Mehrnaz Atighehchian Abbas Azimi Khorasani Golshan Latifi Source Type: research
Clinical Outcomes of Femtosecond Laser-assisted Implantation of 325-Degree Versus 340-Degree Arc Length Intracorneal Ring Segments in Naive Keratoconic Eyes
CONCLUSION: Both the 325-degree ICRS and the 340-degree ICRS effectively and equally improved visual, refractive, and keratometric outcomes in keratoconic eyes.PMID:38250234 | PMC:PMC10794807 | DOI:10.18502/jovr.v18i4.14545 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - January 22, 2024 Category: Opthalmology Authors: Amir Faramarzi Kiana Hassanpour Marjan Mazouchi Bahram Einollahi Sepehr Feizi Hamed Esfandiari Mohammad-Mehdi Sadoughi Majid Moshirfar Source Type: research
Agreement Between Swept-source Optical Coherence Tomography and Rotating Scheimpflug Camera in Measurement of Corneal Parameters in Normal and Keratoconic Eyes
CONCLUSION: Although the devices had different mean indices values, they had a good agreement based on the Bland-Altman plots. Since Pentacam is accepted as the standard tool for diagnosing ectatic cornea, pentacam CASIA2 is also helpful for early diagnosis of KCN.PMID:38250237 | PMC:PMC10794808 | DOI:10.18502/jovr.v18i4.14547 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - January 22, 2024 Category: Opthalmology Authors: Hamed Ghassemi Mehran Zarei-Ghanavati Mina Khastavan Mehrnaz Atighehchian Abbas Azimi Khorasani Golshan Latifi Source Type: research
Clinical Outcomes of Femtosecond Laser-assisted Implantation of 325-Degree Versus 340-Degree Arc Length Intracorneal Ring Segments in Naive Keratoconic Eyes
CONCLUSION: Both the 325-degree ICRS and the 340-degree ICRS effectively and equally improved visual, refractive, and keratometric outcomes in keratoconic eyes.PMID:38250234 | PMC:PMC10794807 | DOI:10.18502/jovr.v18i4.14545 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - January 22, 2024 Category: Opthalmology Authors: Amir Faramarzi Kiana Hassanpour Marjan Mazouchi Bahram Einollahi Sepehr Feizi Hamed Esfandiari Mohammad-Mehdi Sadoughi Majid Moshirfar Source Type: research
Clinical, Anatomical, and Densitometric Changes following Dresden vs. Accelerated Corneal Cross-Linking in Progressive Keratoconus
CONCLUSION: ACXL and DCXL effectively halted KC progression. ACXL proved to be a safe time-saving alternative to conventional DCXL. DCXL led to a reduction in CCT and an increment in the CD of the central anterior stroma during 24 months of follow-up.PMID:38232738 | DOI:10.1055/a-2206-1420 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - January 17, 2024 Category: Opthalmology Authors: Julia Prinz David Kuerten Hannah Schellhase Antonis Koutsonas Yassin Djalali-Talab Peter Walter Matthias Fuest Source Type: research
Corneal Epithelial Thickness Mapping: A Major Review
J Ophthalmol. 2024 Jan 2;2024:6674747. doi: 10.1155/2024/6674747. eCollection 2024.ABSTRACTThe corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling. In this comprehensive synthesis, we reviewed all available data on ETM with different methods, including very high-frequency ultrasound (V...
Source: Journal of Ophthalmology - January 11, 2024 Category: Opthalmology Authors: Mohammad-Ali Abtahi Amir Hushang Beheshtnejad Golshan Latifi Marjan Akbari-Kamrani Sadegh Ghafarian Ahmad Masoomi Seyed Ali Sonbolastan Hamidreaza Jahanbani-Ardakani Mehrnaz Atighechian Laleh Banan Hosein Nouri Seyed-Hossein Abtahi Source Type: research
Transcriptional profiling specifies the pathogen-specific human host response to infectious keratitis
ConclusionsHigh-resolution molecular profiling provides new insights into the human corneal host response to viral and bacterial/fungal infection. Pathogen-specific molecular profiles may provide the foundation for novel diagnostic biomarker and therapeutic approaches that target inflammation-induced damage to corneal host cells with the goal to improve the outcome of infectious keratitis. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 11, 2024 Category: Microbiology Source Type: research
Patterns in refractive error and treatment delay in keratoconus –An Australian study
by Samantha Bobba, Alanna Wood, John Males, Yves Kerdraon
Keratoconus is the most common primary corneal ectasia and is associated with significant morbidity. In its early stages, keratoconus is often asymptomatic, making the identification of subclinical disease challenging. Refractive error is a parameter that is documented at most routine optometry vi sits, yet interestingly, changes in refraction of keratoconic patients over time have not yet been studied and compared with the general population. Early diagnosis of keratoconus facilitates timely referral for treatments such as corneal collagen cross-linking, which has...
Source: PLoS One - January 11, 2024 Category: Biomedical Science Authors: Samantha Bobba Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
Squishy matters - Corneal mechanobiology in health and disease
Prog Retin Eye Res. 2024 Jan 2:101234. doi: 10.1016/j.preteyeres.2023.101234. Online ahead of print.ABSTRACTThe cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces in order to maintain its structural integrity, barrier function, transparency and refractive power. Cells within the cornea sense and respond to various mechanical forces that fundamentally regulate their morphology and fate in development, homeostasis and pathophysiology. Corneal cells also dynamically regulate their extracellular matrix (ECM) with ensuing cell-ECM crosstalk as the matrix serves as a dynamic signaling reservo...
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Sara M Thomasy Brian C Leonard Mark A Greiner Jessica M Skeie Vijay Krishna Raghunathan Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
Human corneal epithelial cell and fibroblast migration and growth factor secretion after rose bengal photodynamic therapy (RB-PDT) and the effect of conditioned medium
by Ning Chai, Tanja Stachon, Tim Berger, Zhen Li, Berthold Seitz, Achim Langenbucher, N óra Szentmáry
PurposeTo investigate human corneal epithelial cell and fibroblast migration and growth factor secretion after rose bengal photodynamic therapy (RB-PDT) and the effect of conditioned medium (CM). MethodsA human corneal epithelial cell line (HCE-T), human corneal fibroblasts (HCF) and keratoconus fibroblasts (KC-HCF) have been used. Twenty-four hours after RB-PDT (0.001% RB concentration, 565 nm wavelength illumination, 0.17 J/cm2 fluence) cell migration rate using scratch assay and growth factor concentrations in the cel...
Source: PLoS One - December 27, 2023 Category: Biomedical Science Authors: Ning Chai Source Type: research
Circular RNA expression profile identifies potential circulating biomarkers for keratoconus
In conclusion, the expression of circRNAs showed a relationship with KC, with four significantly differentially expressed circRNAs demonstrating potential as biomarkers for the disease.PMID:38142763 | DOI:10.1016/j.exer.2023.109759 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 24, 2023 Category: Opthalmology Authors: Xiao-Dan Hao Hai-Pai Gong Fei Li Sheng-Wei Ren Pei-Feng Li Source Type: research
Investigation of the safety and effectiveness of accelerated contact lens-assisted corneal cross-linking (A-CACXL) in thin corneas
CONCLUSION: A-CACXL method is a safe and effective method to stop keratoconic progression and improve functional vision in patients with thin corneas. However, larger randomised controlled studies are needed to validate these findings.PMID:38130115 | DOI:10.1177/11206721231222946 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - December 22, 2023 Category: Opthalmology Authors: Gulderen Karaca Serap Yurttaser Ocak Source Type: research
