Genes, Vol. 14, Pages 2108: Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort
This study included 98 KC cases and 167 controls. Polymorphisms rs6187644 and rs138380 were genotyped using TaqMan assays, and rs429358 and rs7412 were genotyped via Sanger sequencing. Although the allele frequency of rs61876744(T) in PNPLA2 was a protective effect against KC (odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.44–0.93), the p-value (p = 0.020) was not significant for multiple testing correction (p = 0.05/4 = 0.015). However, rs6187644 genotype showed a modestly significant protective effect in the dominant model (OR = 0.53, 95% CI = 0.32–0.88, p = 0.013). Polymorphisms rs1...
Source: Genes - November 21, 2023 Category: Genetics & Stem Cells Authors: Altaf A. Kondkar Taif A. Azad Tahira Sultan Tanvir Khatlani Abdulaziz A. Alshehri Glenn P. Lobo Hatem Kalantan Saleh A. Al-Obeidan Abdulrahman M. Al-Muammar Tags: Article Source Type: research
Identification of genetic variants in two families with Keratoconus
This research investigated the genetic characteristic of two Chinese families with keratoconus (KC). (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - November 21, 2023 Category: Genetics & Stem Cells Authors: Qinghong Lin, Xuejun Wang, Tian Han and Xingtao Zhou Tags: Research Source Type: research
Observation and assessment of the immediate use of a silicon hydrogel contact lens after transepithelial corneal cross linking: a prospective study
Transepithelial corneal crosslinking (CXL) is a novel surgical approach for the treatment of keratoconus, which is a bilateral asymmetrical ophthalmological disease accompanied by progressive corneal ectasia. ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - November 20, 2023 Category: Opthalmology Authors: Liu Liu, Teruko Fukuyama, Tian Han, Zhe Zhang, Lin Jiang, Yanlan Ding, Xingtao Zhou and Jifang Wang Tags: Research Source Type: research
Artificial intelligence for detecting keratoconus
CONCLUSIONS: AI appears to be a promising triage tool in ophthalmologic practice for diagnosing keratoconus. Test accuracy was very high for manifest keratoconus and slightly lower for subclinical keratoconus, indicating a higher chance of missing a diagnosis in people without clinical signs. This could lead to progression of keratoconus or an erroneous indication for refractive surgery, which would worsen the disease. We are unable to draw clear and reliable conclusions due to the high risk of bias, the unexplained heterogeneity of the results, and high applicability concerns, all of which reduced our confidence in the ev...
Source: Cochrane Database of Systematic Reviews - November 15, 2023 Category: General Medicine Authors: Magali Ms Vandevenne Eleonora Favuzza Mitko Veta Ersilia Lucenteforte Tos Tjm Berendschot Rita Mencucci Rudy Mma Nuijts Gianni Virgili Mor M Dickman Source Type: research
Artificial intelligence for detecting keratoconus
CONCLUSIONS: AI appears to be a promising triage tool in ophthalmologic practice for diagnosing keratoconus. Test accuracy was very high for manifest keratoconus and slightly lower for subclinical keratoconus, indicating a higher chance of missing a diagnosis in people without clinical signs. This could lead to progression of keratoconus or an erroneous indication for refractive surgery, which would worsen the disease. We are unable to draw clear and reliable conclusions due to the high risk of bias, the unexplained heterogeneity of the results, and high applicability concerns, all of which reduced our confidence in the ev...
Source: Cochrane Database of Systematic Reviews - November 15, 2023 Category: General Medicine Authors: Magali Ms Vandevenne Eleonora Favuzza Mitko Veta Ersilia Lucenteforte Tos Tjm Berendschot Rita Mencucci Rudy Mma Nuijts Gianni Virgili Mor M Dickman Source Type: research
Prevalence and economic burden of Keratoconus in the United States
To assess the prevalence and economic burden of Keratoconus in the United States. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - November 9, 2023 Category: Opthalmology Authors: Rohan Bir Singh, Uday Pratap Singh Parmar, Vishal Jhanji Tags: Original Articles Source Type: research
New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration
Stem Cell Res Ther. 2023 Nov 6;14(1):317. doi: 10.1186/s13287-023-03548-5.ABSTRACTKeratoconus is a progressive, ectatic and blinding disorder of the cornea, characterized by thinning of corneal stroma. As a highly prevalent among adolescents, keratoconus has been a leading indication for corneal transplantation worldwide. However, the severe shortage of donor corneas is a global issue, and the traditional corneal transplantation surgeries may superinduce multiple complications, necessitating efforts to develop more effective strategies for keratoconus treatment. In this review, we summarized several strategies to promote c...
Source: Cell Research - November 7, 2023 Category: Cytology Authors: Shengqian Dou Xiaoxue Liu Weiyun Shi Hua Gao Source Type: research
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice
This study indicates that VAD affects the transcriptomics of murine cornea with gender differences, which specifically affects the inflammatory status of the female murine cornea.PMID:37931772 | DOI:10.1016/j.exer.2023.109714 (Source: Experimental Eye Research)
Source: Experimental Eye Research - November 6, 2023 Category: Opthalmology Authors: Hanrui Yu Jie Wu Kaixiu Li Yulei Huang Tengyun Wu Liqiang Wang Yifei Huang Source Type: research
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice
This study indicates that VAD affects the transcriptomics of murine cornea with gender differences, which specifically affects the inflammatory status of the female murine cornea.PMID:37931772 | DOI:10.1016/j.exer.2023.109714 (Source: Experimental Eye Research)
Source: Experimental Eye Research - November 6, 2023 Category: Opthalmology Authors: Hanrui Yu Jie Wu Kaixiu Li Yulei Huang Tengyun Wu Liqiang Wang Yifei Huang Source Type: research
Bowman layer onlay grafting as a minimally invasive treatment for the most challenging cases in keratoconus
To analyze the clinical outcomes after Bowman layer (BL) onlay grafting for the treatment of progressive, advanced keratoconus. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - November 5, 2023 Category: Opthalmology Authors: Lydia van der Star, Indr ė Vasiliauskaitė, Silke Oellerich, Esther A. Groeneveld-van Beek, Mohamed Ghaly, Achraf Laouani, Keamela Vasanthananthan, Korine van Dijk, Isabel Dapena, Gerrit R.J. Melles, Viridiana Kocaba Tags: Original Articles Source Type: research
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF- κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, < em > In Vitro < /em >
CONCLUSIONS: Our study demonstrates that RB-PDT reduces collagen I, collagen V and TGF-β1 mRNA expression, while increasing IL-6 mRNA and protein expression in KC-HCFs. In HCFs, RB-PDT increases TGF-β1 and IL-6 protein level after 24 h.PMID:37921272 | DOI:10.1080/02713683.2023.2276057 (Source: Current Eye Research)
Source: Current Eye Research - November 3, 2023 Category: Opthalmology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF- κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, < em > In Vitro < /em >
CONCLUSIONS: Our study demonstrates that RB-PDT reduces collagen I, collagen V and TGF-β1 mRNA expression, while increasing IL-6 mRNA and protein expression in KC-HCFs. In HCFs, RB-PDT increases TGF-β1 and IL-6 protein level after 24 h.PMID:37921272 | DOI:10.1080/02713683.2023.2276057 (Source: Cell Research)
Source: Cell Research - November 3, 2023 Category: Cytology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF- κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, < em > In Vitro < /em >
CONCLUSIONS: Our study demonstrates that RB-PDT reduces collagen I, collagen V and TGF-β1 mRNA expression, while increasing IL-6 mRNA and protein expression in KC-HCFs. In HCFs, RB-PDT increases TGF-β1 and IL-6 protein level after 24 h.PMID:37921272 | DOI:10.1080/02713683.2023.2276057 (Source: Current Eye Research)
Source: Current Eye Research - November 3, 2023 Category: Opthalmology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF- κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, < em > In Vitro < /em >
CONCLUSIONS: Our study demonstrates that RB-PDT reduces collagen I, collagen V and TGF-β1 mRNA expression, while increasing IL-6 mRNA and protein expression in KC-HCFs. In HCFs, RB-PDT increases TGF-β1 and IL-6 protein level after 24 h.PMID:37921272 | DOI:10.1080/02713683.2023.2276057 (Source: Cell Research)
Source: Cell Research - November 3, 2023 Category: Cytology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF- κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, < em > In Vitro < /em >
CONCLUSIONS: Our study demonstrates that RB-PDT reduces collagen I, collagen V and TGF-β1 mRNA expression, while increasing IL-6 mRNA and protein expression in KC-HCFs. In HCFs, RB-PDT increases TGF-β1 and IL-6 protein level after 24 h.PMID:37921272 | DOI:10.1080/02713683.2023.2276057 (Source: Current Eye Research)
Source: Current Eye Research - November 3, 2023 Category: Opthalmology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research
