Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Feel so bac: is Fusobacterium the suspect causing endometriosis?
Trends Mol Med. 2023 Aug 18:S1471-4914(23)00188-0. doi: 10.1016/j.molmed.2023.08.003. Online ahead of print.ABSTRACTRecent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.PMID:37599125 | DOI:10.1016/j.molmed.2023.08.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 20, 2023 Category: Molecular Biology Authors: Huan-Tzu Hou Ting-Chien Lin Meng-Hsing Wu Shaw-Jenq Tsai Source Type: research
Mind the (guidance) signals! Translational relevance of semaphorins, plexins, and neuropilins in pancreatic cancer
Trends Mol Med. 2023 Aug 17:S1471-4914(23)00159-4. doi: 10.1016/j.molmed.2023.07.009. Online ahead of print.ABSTRACTPancreatic cancer is a major cause of demise worldwide. Although key associated genetic changes have been discovered, disease progression is sustained by pathogenic mechanisms that are poorly understood at the molecular level. In particular, the tissue microenvironment of pancreatic adenocarcinoma (PDAC) is usually characterized by high stromal content, scarce recruitment of immune cells, and the presence of neuronal fibers. Semaphorins and their receptors, plexins and neuropilins, comprise a wide family of r...
Source: Trends in Molecular Medicine - August 19, 2023 Category: Molecular Biology Authors: Damon Fard Enrico Giraudo Luca Tamagnone Source Type: research
Mind the (guidance) signals! Translational relevance of semaphorins, plexins, and neuropilins in pancreatic cancer
Trends Mol Med. 2023 Aug 17:S1471-4914(23)00159-4. doi: 10.1016/j.molmed.2023.07.009. Online ahead of print.ABSTRACTPancreatic cancer is a major cause of demise worldwide. Although key associated genetic changes have been discovered, disease progression is sustained by pathogenic mechanisms that are poorly understood at the molecular level. In particular, the tissue microenvironment of pancreatic adenocarcinoma (PDAC) is usually characterized by high stromal content, scarce recruitment of immune cells, and the presence of neuronal fibers. Semaphorins and their receptors, plexins and neuropilins, comprise a wide family of r...
Source: Trends in Molecular Medicine - August 19, 2023 Category: Molecular Biology Authors: Damon Fard Enrico Giraudo Luca Tamagnone Source Type: research
Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics
Trends Mol Med. 2023 Aug 15:S1471-4914(23)00160-0. doi: 10.1016/j.molmed.2023.07.010. Online ahead of print.ABSTRACTOligodendrocytes (OLGs), highly specialized glial cells that wrap axons with myelin sheaths, are critical for brain development and function. There is new recognition of the role of OLGs in the pathogenesis of neurodegenerative diseases (NDDs), including Huntington's disease (HD), a prototypic NDD caused by a polyglutamine tract expansion in huntingtin (HTT), which results in gain- and loss-of-function effects. Clinically, HD is characterized by a constellation of motor, cognitive, and psychiatric disturbance...
Source: Trends in Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Costanza Ferrari Bardile Carola I Radulescu Mahmoud A Pouladi Source Type: research
Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics
Trends Mol Med. 2023 Aug 15:S1471-4914(23)00160-0. doi: 10.1016/j.molmed.2023.07.010. Online ahead of print.ABSTRACTOligodendrocytes (OLGs), highly specialized glial cells that wrap axons with myelin sheaths, are critical for brain development and function. There is new recognition of the role of OLGs in the pathogenesis of neurodegenerative diseases (NDDs), including Huntington's disease (HD), a prototypic NDD caused by a polyglutamine tract expansion in huntingtin (HTT), which results in gain- and loss-of-function effects. Clinically, HD is characterized by a constellation of motor, cognitive, and psychiatric disturbance...
Source: Trends in Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Costanza Ferrari Bardile Carola I Radulescu Mahmoud A Pouladi Source Type: research
Roadmap for developing biologically inspired therapeutics for genetic brain disorders
Trends Mol Med. 2023 Aug 14:S1471-4914(23)00155-7. doi: 10.1016/j.molmed.2023.07.005. Online ahead of print.NO ABSTRACTPMID:37586931 | DOI:10.1016/j.molmed.2023.07.005 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 16, 2023 Category: Molecular Biology Authors: Kent Imaizumi Sergiu P Pa şca Source Type: research
Roadmap for developing biologically inspired therapeutics for genetic brain disorders
Trends Mol Med. 2023 Aug 14:S1471-4914(23)00155-7. doi: 10.1016/j.molmed.2023.07.005. Online ahead of print.NO ABSTRACTPMID:37586931 | DOI:10.1016/j.molmed.2023.07.005 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - August 16, 2023 Category: Molecular Biology Authors: Kent Imaizumi Sergiu P Pa şca Source Type: research
