Redefining metalloproteases specificity through network proteolysis
Trends Mol Med. 2023 Nov 29:S1471-4914(23)00263-0. doi: 10.1016/j.molmed.2023.11.001. Online ahead of print.ABSTRACTProteolytic processes on cell surfaces and extracellular matrix (ECM) sustain cell behavior and tissue integrity in health and disease. Matrix metalloproteases (MMPs) and a disintegrin and metalloproteases (ADAMs) remodel cell microenvironments through irreversible proteolysis of ECM proteins and cell surface bioactive molecules. Pan-MMP inhibitors in inflammation and cancer clinical trials have encountered challenges due to promiscuous activities of MMPs. Systems biology advances revealed that MMPs initiate ...
Source: Trends in Molecular Medicine - November 30, 2023 Category: Molecular Biology Authors: Orit Kollet Alakesh Das Nikos Karamanos Ulrich Auf dem Keller Irit Sagi Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
Digital health applications for eating disorders treatment
Trends Mol Med. 2023 Nov 22:S1471-4914(23)00266-6. doi: 10.1016/j.molmed.2023.11.004. Online ahead of print.ABSTRACTEating disorders (EDs) are characterized by multifaceted etiologies, difficulties in accessing care (especially in regional locations), and variable responsiveness to treatments. Digital technologies are viewed as an important innovation in the assessment and treatment of EDs. We discuss current implementation of these innovations as well as important future directions for the field.PMID:37996311 | DOI:10.1016/j.molmed.2023.11.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 23, 2023 Category: Molecular Biology Authors: Matthew Fuller-Tyszkiewicz Mariel Messer Isabel Krug Jake Linardon Source Type: research
Digital health applications for eating disorders treatment
Trends Mol Med. 2023 Nov 22:S1471-4914(23)00266-6. doi: 10.1016/j.molmed.2023.11.004. Online ahead of print.ABSTRACTEating disorders (EDs) are characterized by multifaceted etiologies, difficulties in accessing care (especially in regional locations), and variable responsiveness to treatments. Digital technologies are viewed as an important innovation in the assessment and treatment of EDs. We discuss current implementation of these innovations as well as important future directions for the field.PMID:37996311 | DOI:10.1016/j.molmed.2023.11.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 23, 2023 Category: Molecular Biology Authors: Matthew Fuller-Tyszkiewicz Mariel Messer Isabel Krug Jake Linardon Source Type: research
Embodiment illusions and eating disorders: snapshot of implications for research and interventions
Trends Mol Med. 2023 Nov 17:S1471-4914(23)00267-8. doi: 10.1016/j.molmed.2023.11.005. Online ahead of print.ABSTRACTIn recent years, researchers have increasingly used the embodiment illusion paradigm in subclinical and clinical eating disorder (ED) populations. This has important implications for understanding and ultimately improving bodily misperception. Here, we provide a brief overview of the current 'state of the art' of these implications while highlighting challenges and future directions.PMID:37981534 | DOI:10.1016/j.molmed.2023.11.005 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 19, 2023 Category: Molecular Biology Authors: Jade Portingale Isabel Krug David Butler Source Type: research
Embodiment illusions and eating disorders: snapshot of implications for research and interventions
Trends Mol Med. 2023 Nov 17:S1471-4914(23)00267-8. doi: 10.1016/j.molmed.2023.11.005. Online ahead of print.ABSTRACTIn recent years, researchers have increasingly used the embodiment illusion paradigm in subclinical and clinical eating disorder (ED) populations. This has important implications for understanding and ultimately improving bodily misperception. Here, we provide a brief overview of the current 'state of the art' of these implications while highlighting challenges and future directions.PMID:37981534 | DOI:10.1016/j.molmed.2023.11.005 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 19, 2023 Category: Molecular Biology Authors: Jade Portingale Isabel Krug David Butler Source Type: research
Embodiment illusions and eating disorders: snapshot of implications for research and interventions
Trends Mol Med. 2023 Nov 17:S1471-4914(23)00267-8. doi: 10.1016/j.molmed.2023.11.005. Online ahead of print.ABSTRACTIn recent years, researchers have increasingly used the embodiment illusion paradigm in subclinical and clinical eating disorder (ED) populations. This has important implications for understanding and ultimately improving bodily misperception. Here, we provide a brief overview of the current 'state of the art' of these implications while highlighting challenges and future directions.PMID:37981534 | DOI:10.1016/j.molmed.2023.11.005 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 19, 2023 Category: Molecular Biology Authors: Jade Portingale Isabel Krug David Butler Source Type: research
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Trends Mol Med. 2023 Nov 15:S1471-4914(23)00236-8. doi: 10.1016/j.molmed.2023.10.001. Online ahead of print.ABSTRACTThe innate immune system initiates cell death pathways in response to pathogens and cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis, and necroptosis). PANoptosis has been identified as an inflammatory, lytic cell death pathway driven by caspases and RIPKs that is regulated by PANoptosome complexes, making it distinct from other cell death pathways. Several PANoptosome complexes (including ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosomes) have been characterized to...
Source: Trends in Molecular Medicine - November 17, 2023 Category: Molecular Biology Authors: Ankit Pandeya Thirumala-Devi Kanneganti Source Type: research
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Trends Mol Med. 2023 Nov 15:S1471-4914(23)00236-8. doi: 10.1016/j.molmed.2023.10.001. Online ahead of print.ABSTRACTThe innate immune system initiates cell death pathways in response to pathogens and cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis, and necroptosis). PANoptosis has been identified as an inflammatory, lytic cell death pathway driven by caspases and RIPKs that is regulated by PANoptosome complexes, making it distinct from other cell death pathways. Several PANoptosome complexes (including ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosomes) have been characterized to...
Source: Trends in Molecular Medicine - November 17, 2023 Category: Molecular Biology Authors: Ankit Pandeya Thirumala-Devi Kanneganti Source Type: research
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Trends Mol Med. 2023 Nov 15:S1471-4914(23)00236-8. doi: 10.1016/j.molmed.2023.10.001. Online ahead of print.ABSTRACTThe innate immune system initiates cell death pathways in response to pathogens and cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis, and necroptosis). PANoptosis has been identified as an inflammatory, lytic cell death pathway driven by caspases and RIPKs that is regulated by PANoptosome complexes, making it distinct from other cell death pathways. Several PANoptosome complexes (including ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosomes) have been characterized to...
Source: Trends in Molecular Medicine - November 17, 2023 Category: Molecular Biology Authors: Ankit Pandeya Thirumala-Devi Kanneganti Source Type: research
RyR-mediated calcium release in hippocampal health and disease
This article highlights the central role of Ca2+ release from the endoplasmic reticulum (ER) in hippocampal synaptic plasticity and hippocampus-dependent memory in health and disease. The key participation of ryanodine receptor (RyR) channels, which are the principal Ca2+ release channels expressed in the hippocampus, in these processes is emphasized. It is proposed that the increased neuronal oxidative tone displayed by hippocampal neurons during aging or Alzheimer's disease (AD) leads to excessive activation of RyR-mediated Ca2+ release, a process that is highly redox-sensitive, and that this abnormal response contribute...
Source: Trends in Molecular Medicine - November 13, 2023 Category: Molecular Biology Authors: Cecilia Hidalgo Andrea Paula-Lima Source Type: research
