Role of intrinsic apoptosis in environmental exposure health outcomes
Trends Mol Med. 2023 Dec 5:S1471-4914(23)00264-2. doi: 10.1016/j.molmed.2023.11.003. Online ahead of print.ABSTRACTEnvironmental exposures are linked to diseases of high public health concern, including cancer, neurodegenerative disorders, and autoimmunity. These diseases are caused by excessive or insufficient cell death, prompting investigation of mechanistic links between environmental toxicants and dysregulation of cell death pathways, including apoptosis. This review describes how legacy and emerging environmental exposures target the intrinsic apoptosis pathway to potentially drive pathogenesis. Recent discoveries re...
Source: Trends in Molecular Medicine - December 6, 2023 Category: Molecular Biology Authors: Lissah Johnson Kristopher A Sarosiek Source Type: research
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases
Trends Mol Med. 2023 Dec 2:S1471-4914(23)00271-X. doi: 10.1016/j.molmed.2023.11.009. Online ahead of print.ABSTRACTInherited retinal diseases (IRDs) stem from genetic mutations that result in vision impairment. Gene therapy shows promising therapeutic potential, exemplified by the encouraging initial results with voretigene neparvovec. Nevertheless, the associated costs impede widespread access, particularly in low-to-middle income countries. The primary challenge remains: how can we make these therapies globally affordable? Leveraging advancements in mRNA therapies might offer a more economically viable alternative. Furth...
Source: Trends in Molecular Medicine - December 3, 2023 Category: Molecular Biology Authors: Pedro Antas Cl áudia Carvalho Joaquim Cabral-Teixeira Lu ísa de Lemos Miguel C Seabra Source Type: research
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases
Trends Mol Med. 2023 Dec 2:S1471-4914(23)00271-X. doi: 10.1016/j.molmed.2023.11.009. Online ahead of print.ABSTRACTInherited retinal diseases (IRDs) stem from genetic mutations that result in vision impairment. Gene therapy shows promising therapeutic potential, exemplified by the encouraging initial results with voretigene neparvovec. Nevertheless, the associated costs impede widespread access, particularly in low-to-middle income countries. The primary challenge remains: how can we make these therapies globally affordable? Leveraging advancements in mRNA therapies might offer a more economically viable alternative. Furth...
Source: Trends in Molecular Medicine - December 3, 2023 Category: Molecular Biology Authors: Pedro Antas Cl áudia Carvalho Joaquim Cabral-Teixeira Lu ísa de Lemos Miguel C Seabra Source Type: research
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases
Trends Mol Med. 2023 Dec 2:S1471-4914(23)00271-X. doi: 10.1016/j.molmed.2023.11.009. Online ahead of print.ABSTRACTInherited retinal diseases (IRDs) stem from genetic mutations that result in vision impairment. Gene therapy shows promising therapeutic potential, exemplified by the encouraging initial results with voretigene neparvovec. Nevertheless, the associated costs impede widespread access, particularly in low-to-middle income countries. The primary challenge remains: how can we make these therapies globally affordable? Leveraging advancements in mRNA therapies might offer a more economically viable alternative. Furth...
Source: Trends in Molecular Medicine - December 3, 2023 Category: Molecular Biology Authors: Pedro Antas Cl áudia Carvalho Joaquim Cabral-Teixeira Lu ísa de Lemos Miguel C Seabra Source Type: research
Reprogramming endothelial cells to empower cancer immunotherapy
Trends Mol Med. 2023 Nov 30:S1471-4914(23)00265-4. doi: 10.1016/j.molmed.2023.11.002. Online ahead of print.ABSTRACTCancer immunity is subject to spatiotemporal regulation by leukocyte interaction with the tumor microenvironment. Growing evidence suggests an emerging role for the vasculature in tumor immune evasion and immunotherapy resistance. Beyond the conventional functions of the tumor vasculature, such as providing oxygen and nutrients to support tumor progression, we propose multiplex mechanisms for vascular regulation of tumor immunity: The immunosuppressive vascular niche locoregionally educates circulation-derive...
Source: Trends in Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Abigail H Cleveland Yi Fan Source Type: research
Eating disorders: are gut microbiota to blame?
Trends Mol Med. 2023 Nov 30:S1471-4914(23)00269-1. doi: 10.1016/j.molmed.2023.11.007. Online ahead of print.ABSTRACTGut microbiota could be involved in weight regulation and impact brain function via the gut-brain axis. Moreover, gut microbiota may impact the development of eating disorders (EDs) since they are characterized by weight-related concerns and symptoms and may represent a therapeutic target if future research can establish a causal link.PMID:38040602 | DOI:10.1016/j.molmed.2023.11.007 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Jiayi Xu Ian M Carroll Laura M Huckins Source Type: research
Reprogramming endothelial cells to empower cancer immunotherapy
Trends Mol Med. 2023 Nov 30:S1471-4914(23)00265-4. doi: 10.1016/j.molmed.2023.11.002. Online ahead of print.ABSTRACTCancer immunity is subject to spatiotemporal regulation by leukocyte interaction with the tumor microenvironment. Growing evidence suggests an emerging role for the vasculature in tumor immune evasion and immunotherapy resistance. Beyond the conventional functions of the tumor vasculature, such as providing oxygen and nutrients to support tumor progression, we propose multiplex mechanisms for vascular regulation of tumor immunity: The immunosuppressive vascular niche locoregionally educates circulation-derive...
Source: Trends in Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Abigail H Cleveland Yi Fan Source Type: research
Eating disorders: are gut microbiota to blame?
Trends Mol Med. 2023 Nov 30:S1471-4914(23)00269-1. doi: 10.1016/j.molmed.2023.11.007. Online ahead of print.ABSTRACTGut microbiota could be involved in weight regulation and impact brain function via the gut-brain axis. Moreover, gut microbiota may impact the development of eating disorders (EDs) since they are characterized by weight-related concerns and symptoms and may represent a therapeutic target if future research can establish a causal link.PMID:38040602 | DOI:10.1016/j.molmed.2023.11.007 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Jiayi Xu Ian M Carroll Laura M Huckins Source Type: research
Redefining metalloproteases specificity through network proteolysis
Trends Mol Med. 2023 Nov 29:S1471-4914(23)00263-0. doi: 10.1016/j.molmed.2023.11.001. Online ahead of print.ABSTRACTProteolytic processes on cell surfaces and extracellular matrix (ECM) sustain cell behavior and tissue integrity in health and disease. Matrix metalloproteases (MMPs) and a disintegrin and metalloproteases (ADAMs) remodel cell microenvironments through irreversible proteolysis of ECM proteins and cell surface bioactive molecules. Pan-MMP inhibitors in inflammation and cancer clinical trials have encountered challenges due to promiscuous activities of MMPs. Systems biology advances revealed that MMPs initiate ...
Source: Trends in Molecular Medicine - November 30, 2023 Category: Molecular Biology Authors: Orit Kollet Alakesh Das Nikos Karamanos Ulrich Auf dem Keller Irit Sagi Source Type: research
Redefining metalloproteases specificity through network proteolysis
Trends Mol Med. 2023 Nov 29:S1471-4914(23)00263-0. doi: 10.1016/j.molmed.2023.11.001. Online ahead of print.ABSTRACTProteolytic processes on cell surfaces and extracellular matrix (ECM) sustain cell behavior and tissue integrity in health and disease. Matrix metalloproteases (MMPs) and a disintegrin and metalloproteases (ADAMs) remodel cell microenvironments through irreversible proteolysis of ECM proteins and cell surface bioactive molecules. Pan-MMP inhibitors in inflammation and cancer clinical trials have encountered challenges due to promiscuous activities of MMPs. Systems biology advances revealed that MMPs initiate ...
Source: Trends in Molecular Medicine - November 30, 2023 Category: Molecular Biology Authors: Orit Kollet Alakesh Das Nikos Karamanos Ulrich Auf dem Keller Irit Sagi Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
The ignored role of disadvantage in eating disorders
Trends Mol Med. 2023 Nov 23:S1471-4914(23)00268-X. doi: 10.1016/j.molmed.2023.11.006. Online ahead of print.ABSTRACTThe misconception that eating disorders are conditions of affluence has shaped research and public understanding for decades. Here, we highlight links between socioeconomic disadvantage and eating disorder risk. With prevailing stereotypes discredited, we argue that considering disadvantage as a key eating disorder risk factor will advance science and reduce disparities.PMID:38000984 | DOI:10.1016/j.molmed.2023.11.006 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: C Blair Burnette S Alexandra Burt Kelly L Klump Source Type: research
