Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Multiomics tools for improved atherosclerotic cardiovascular disease management
Trends Mol Med. 2023 Oct 6:S1471-4914(23)00219-8. doi: 10.1016/j.molmed.2023.09.004. Online ahead of print.ABSTRACTMultiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) approaches, it is possible to integrate multiple 'omics and clinical data sets into tools that can be utilized for the development of personalized diagnostic and therapeutic approaches. However, currently multiple challenges in data quality, integration, and privacy still need to be addressed. ...
Source: Trends in Molecular Medicine - October 8, 2023 Category: Molecular Biology Authors: Miron Sopic Baiba Vilne Eva Gerdts F ábio Trindade Shizuka Uchida Soliman Khatib Stephanie Bezzina Wettinger Yvan Devaux Paolo Magni EU-AtheroNET COST Action CA21153 Source Type: research
Multiomics tools for improved atherosclerotic cardiovascular disease management
Trends Mol Med. 2023 Oct 6:S1471-4914(23)00219-8. doi: 10.1016/j.molmed.2023.09.004. Online ahead of print.ABSTRACTMultiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) approaches, it is possible to integrate multiple 'omics and clinical data sets into tools that can be utilized for the development of personalized diagnostic and therapeutic approaches. However, currently multiple challenges in data quality, integration, and privacy still need to be addressed. ...
Source: Trends in Molecular Medicine - October 8, 2023 Category: Molecular Biology Authors: Miron Sopic Baiba Vilne Eva Gerdts F ábio Trindade Shizuka Uchida Soliman Khatib Stephanie Bezzina Wettinger Yvan Devaux Paolo Magni EU-AtheroNET COST Action CA21153 Source Type: research
Multiomics tools for improved atherosclerotic cardiovascular disease management
Trends Mol Med. 2023 Oct 6:S1471-4914(23)00219-8. doi: 10.1016/j.molmed.2023.09.004. Online ahead of print.ABSTRACTMultiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) approaches, it is possible to integrate multiple 'omics and clinical data sets into tools that can be utilized for the development of personalized diagnostic and therapeutic approaches. However, currently multiple challenges in data quality, integration, and privacy still need to be addressed. ...
Source: Trends in Molecular Medicine - October 8, 2023 Category: Molecular Biology Authors: Miron Sopic Baiba Vilne Eva Gerdts F ábio Trindade Shizuka Uchida Soliman Khatib Stephanie Bezzina Wettinger Yvan Devaux Paolo Magni EU-AtheroNET COST Action CA21153 Source Type: research
Multiomics tools for improved atherosclerotic cardiovascular disease management
Trends Mol Med. 2023 Oct 6:S1471-4914(23)00219-8. doi: 10.1016/j.molmed.2023.09.004. Online ahead of print.ABSTRACTMultiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) approaches, it is possible to integrate multiple 'omics and clinical data sets into tools that can be utilized for the development of personalized diagnostic and therapeutic approaches. However, currently multiple challenges in data quality, integration, and privacy still need to be addressed. ...
Source: Trends in Molecular Medicine - October 8, 2023 Category: Molecular Biology Authors: Miron Sopic Baiba Vilne Eva Gerdts F ábio Trindade Shizuka Uchida Soliman Khatib Stephanie Bezzina Wettinger Yvan Devaux Paolo Magni EU-AtheroNET COST Action CA21153 Source Type: research
Human genetics and molecular genomics of Chiari malformation type 1
Trends Mol Med. 2023 Oct 4:S1471-4914(23)00215-0. doi: 10.1016/j.molmed.2023.08.013. Online ahead of print.ABSTRACTChiari malformation type 1 (CM1) is the most common structural brain disorder involving the pboard1 junction, characterized by caudal displacement of the cerebellar tonsils below the foramen magnum into the spinal canal. Despite the heterogeneity of CM1, its poorly understood patho-etiology has led to a 'one-size-fits-all' surgical approach, with predictably high rates of morbidity and treatment failure. In this review we present multiplex CM1 families, associated Mendelian syndromes, and candidate genes from ...
Source: Trends in Molecular Medicine - October 6, 2023 Category: Molecular Biology Authors: Kedous Y Mekbib William Mu ñoz Garrett Allington Stephen McGee Neel H Mehta John P Shofi Carla Fortes Hao Thi Le Carol Nelson-Williams Pranav Nanda Evan Dennis Adam J Kundishora Arjun Khanna Hannah Smith Jack Ocken Ana B W Greenberg Rui Wu Andres Moreno- Source Type: research
