FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00279-4. doi: 10.1016/j.molmed.2023.11.017. Online ahead of print.ABSTRACTEncephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is an autosomal recessive disorder arising from biallelic F-box and leucine-rich repeat (LRR) protein 4 (FBXL4) gene mutations. Recent advances have shown that excessive BCL2 interacting protein 3 (BNIP3)/ BCL2 interacting protein 3 like (BNIP3L)-dependent mitophagy underlies the molecular pathogenesis of MTDPS13. Here, we provide an overview of these groundbreaking findings and discuss potential therapeutic strategies for this fatal...
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Kun Gao Xiayun Xu Chenji Wang Source Type: research
Endocrinology-informed neuroimaging in eating disorders: GLP1, orexins, and psilocybin
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00280-0. doi: 10.1016/j.molmed.2023.12.001. Online ahead of print.ABSTRACTThe neurobiology of eating disorders [EDs; anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED)] remains poorly understood. Here, I describe how neuroimaging, accompanied by peripheral endocrine measures, can provide insights into the neurobiological drivers of eating disorders. Orexins/hypocretins, glucagon-like peptide-1 receptor (GLP1R) agonists, and psilocybin are highlighted as avenues for investigation.PMID:38123380 | DOI:10.1016/j.molmed.2023.12.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Trevor Steward Source Type: research
FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00279-4. doi: 10.1016/j.molmed.2023.11.017. Online ahead of print.ABSTRACTEncephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is an autosomal recessive disorder arising from biallelic F-box and leucine-rich repeat (LRR) protein 4 (FBXL4) gene mutations. Recent advances have shown that excessive BCL2 interacting protein 3 (BNIP3)/ BCL2 interacting protein 3 like (BNIP3L)-dependent mitophagy underlies the molecular pathogenesis of MTDPS13. Here, we provide an overview of these groundbreaking findings and discuss potential therapeutic strategies for this fatal...
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Kun Gao Xiayun Xu Chenji Wang Source Type: research
Endocrinology-informed neuroimaging in eating disorders: GLP1, orexins, and psilocybin
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00280-0. doi: 10.1016/j.molmed.2023.12.001. Online ahead of print.ABSTRACTThe neurobiology of eating disorders [EDs; anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED)] remains poorly understood. Here, I describe how neuroimaging, accompanied by peripheral endocrine measures, can provide insights into the neurobiological drivers of eating disorders. Orexins/hypocretins, glucagon-like peptide-1 receptor (GLP1R) agonists, and psilocybin are highlighted as avenues for investigation.PMID:38123380 | DOI:10.1016/j.molmed.2023.12.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Trevor Steward Source Type: research
FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00279-4. doi: 10.1016/j.molmed.2023.11.017. Online ahead of print.ABSTRACTEncephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is an autosomal recessive disorder arising from biallelic F-box and leucine-rich repeat (LRR) protein 4 (FBXL4) gene mutations. Recent advances have shown that excessive BCL2 interacting protein 3 (BNIP3)/ BCL2 interacting protein 3 like (BNIP3L)-dependent mitophagy underlies the molecular pathogenesis of MTDPS13. Here, we provide an overview of these groundbreaking findings and discuss potential therapeutic strategies for this fatal...
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Kun Gao Xiayun Xu Chenji Wang Source Type: research
Endocrinology-informed neuroimaging in eating disorders: GLP1, orexins, and psilocybin
Trends Mol Med. 2023 Dec 19:S1471-4914(23)00280-0. doi: 10.1016/j.molmed.2023.12.001. Online ahead of print.ABSTRACTThe neurobiology of eating disorders [EDs; anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED)] remains poorly understood. Here, I describe how neuroimaging, accompanied by peripheral endocrine measures, can provide insights into the neurobiological drivers of eating disorders. Orexins/hypocretins, glucagon-like peptide-1 receptor (GLP1R) agonists, and psilocybin are highlighted as avenues for investigation.PMID:38123380 | DOI:10.1016/j.molmed.2023.12.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 20, 2023 Category: Molecular Biology Authors: Trevor Steward Source Type: research
Taking better advantage of the activity-based anorexia model
Trends Mol Med. 2023 Dec 15:S1471-4914(23)00273-3. doi: 10.1016/j.molmed.2023.11.011. Online ahead of print.ABSTRACTThe lack of specific treatments for anorexia nervosa (AN) is partly driven by an inadequate understanding of the neurobiological drivers of the condition. The activity-based anorexia (ABA) model recapitulates key characteristics of AN in rats and mice, and can be used to understand factors that predispose, maintain, and rescue anorectic behaviour. With the rapidly evolving suite of technologies to manipulate and record neural activity during the development of ABA, we are better placed than ever before to tak...
Source: Trends in Molecular Medicine - December 16, 2023 Category: Molecular Biology Authors: Claire J Foldi Source Type: research
Taking better advantage of the activity-based anorexia model
Trends Mol Med. 2023 Dec 15:S1471-4914(23)00273-3. doi: 10.1016/j.molmed.2023.11.011. Online ahead of print.ABSTRACTThe lack of specific treatments for anorexia nervosa (AN) is partly driven by an inadequate understanding of the neurobiological drivers of the condition. The activity-based anorexia (ABA) model recapitulates key characteristics of AN in rats and mice, and can be used to understand factors that predispose, maintain, and rescue anorectic behaviour. With the rapidly evolving suite of technologies to manipulate and record neural activity during the development of ABA, we are better placed than ever before to tak...
Source: Trends in Molecular Medicine - December 16, 2023 Category: Molecular Biology Authors: Claire J Foldi Source Type: research
Taking better advantage of the activity-based anorexia model
Trends Mol Med. 2023 Dec 15:S1471-4914(23)00273-3. doi: 10.1016/j.molmed.2023.11.011. Online ahead of print.ABSTRACTThe lack of specific treatments for anorexia nervosa (AN) is partly driven by an inadequate understanding of the neurobiological drivers of the condition. The activity-based anorexia (ABA) model recapitulates key characteristics of AN in rats and mice, and can be used to understand factors that predispose, maintain, and rescue anorectic behaviour. With the rapidly evolving suite of technologies to manipulate and record neural activity during the development of ABA, we are better placed than ever before to tak...
Source: Trends in Molecular Medicine - December 16, 2023 Category: Molecular Biology Authors: Claire J Foldi Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
TIM-3 blockade: immune and targeted therapy in DIPG
Trends Mol Med. 2023 Dec 12:S1471-4914(23)00276-9. doi: 10.1016/j.molmed.2023.11.014. Online ahead of print.ABSTRACTDiffuse intrinsic pontine glioma (DIPG) remains intractable to conventional treatments. While targeted therapy and immuno-oncology advances offer hope, few strategies show promising results. In a recent article in Cancer Cell, Ausejo-Mauleon et al. introduce TIM-3 blockade as a potential breakthrough for DIPG treatment by targeting cancer cells and regulating the immune microenvironment simultaneously.PMID:38092623 | DOI:10.1016/j.molmed.2023.11.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 13, 2023 Category: Molecular Biology Authors: Yan Hu Peishan Hu Xiaozhong Peng Source Type: research
TIM-3 blockade: immune and targeted therapy in DIPG
Trends Mol Med. 2023 Dec 12:S1471-4914(23)00276-9. doi: 10.1016/j.molmed.2023.11.014. Online ahead of print.ABSTRACTDiffuse intrinsic pontine glioma (DIPG) remains intractable to conventional treatments. While targeted therapy and immuno-oncology advances offer hope, few strategies show promising results. In a recent article in Cancer Cell, Ausejo-Mauleon et al. introduce TIM-3 blockade as a potential breakthrough for DIPG treatment by targeting cancer cells and regulating the immune microenvironment simultaneously.PMID:38092623 | DOI:10.1016/j.molmed.2023.11.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - December 13, 2023 Category: Molecular Biology Authors: Yan Hu Peishan Hu Xiaozhong Peng Source Type: research
Role of intrinsic apoptosis in environmental exposure health outcomes
Trends Mol Med. 2023 Dec 5:S1471-4914(23)00264-2. doi: 10.1016/j.molmed.2023.11.003. Online ahead of print.ABSTRACTEnvironmental exposures are linked to diseases of high public health concern, including cancer, neurodegenerative disorders, and autoimmunity. These diseases are caused by excessive or insufficient cell death, prompting investigation of mechanistic links between environmental toxicants and dysregulation of cell death pathways, including apoptosis. This review describes how legacy and emerging environmental exposures target the intrinsic apoptosis pathway to potentially drive pathogenesis. Recent discoveries re...
Source: Trends in Molecular Medicine - December 6, 2023 Category: Molecular Biology Authors: Lissah Johnson Kristopher A Sarosiek Source Type: research
