CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment
Trends Mol Med. 2023 Oct 18:S1471-4914(23)00238-1. doi: 10.1016/j.molmed.2023.10.003. Online ahead of print.ABSTRACTYang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses. This dual-action approach effectively curtails distant tumor growth, marking a pivotal advancement in cancer immunotherapy.PMID:37863716 | DOI:10.1016/j.molmed.2023.10.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Rahela Zaman Xiaojun Cai Quazi T H Shubhra Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
Diabetes: a tipping point in neurodegenerative diseases
Trends Mol Med. 2023 Oct 10:S1471-4914(23)00220-4. doi: 10.1016/j.molmed.2023.09.005. Online ahead of print.ABSTRACTDiabetes is associated with an increased risk and progression of Alzheimer's (AD) and Parkinson's (PD) diseases. Conversely, diabetes may confer neuroprotection against amyotrophic lateral sclerosis (ALS). It has been posited that perturbations in glucose and insulin regulation, cholesterol metabolism, and mitochondrial bioenergetics defects may underlie the molecular underpinnings of diabetes effects on the brain. Nevertheless, the precise molecular mechanisms remain elusive. Here, we discuss the evidence fr...
Source: Trends in Molecular Medicine - October 12, 2023 Category: Molecular Biology Authors: Jose A Santiago Mridula Karthikeyan Madison Lackey Diana Villavicencio Judith A Potashkin Source Type: research
