Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Trends in Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Trends in Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Trends in Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Trends in Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Trends in Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Medical education empowered by generative artificial intelligence large language models
Trends Mol Med. 2023 Sep 15:S1471-4914(23)00211-3. doi: 10.1016/j.molmed.2023.08.012. Online ahead of print.ABSTRACTGenerative artificial intelligence (GAI) large language models (LLMs), like ChatGPT, have become the world's fastest growing applications. Here, we provide useful strategies for educators in medical and health science (M&HS) to integrate GAI-LLMs into learning and teaching practice, ultimately enhancing students' digital capability.PMID:37718142 | DOI:10.1016/j.molmed.2023.08.012 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - September 17, 2023 Category: Molecular Biology Authors: Tanisha Jowsey Jessica Stokes-Parish Rachelle Singleton Michael Todorovic Source Type: research
Medical education empowered by generative artificial intelligence large language models
Trends Mol Med. 2023 Sep 15:S1471-4914(23)00211-3. doi: 10.1016/j.molmed.2023.08.012. Online ahead of print.ABSTRACTGenerative artificial intelligence (GAI) large language models (LLMs), like ChatGPT, have become the world's fastest growing applications. Here, we provide useful strategies for educators in medical and health science (M&HS) to integrate GAI-LLMs into learning and teaching practice, ultimately enhancing students' digital capability.PMID:37718142 | DOI:10.1016/j.molmed.2023.08.012 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - September 17, 2023 Category: Molecular Biology Authors: Tanisha Jowsey Jessica Stokes-Parish Rachelle Singleton Michael Todorovic Source Type: research
Total recall: the role of PIDDosome components in neurodegeneration
Trends Mol Med. 2023 Sep 14:S1471-4914(23)00193-4. doi: 10.1016/j.molmed.2023.08.008. Online ahead of print.ABSTRACTThe PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell differentiation, tissue homeostasis, and organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal development was shown. Here, we focus on th...
Source: Trends in Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Pavel I Volik Gelina S Kopeina Boris Zhivotovsky Alexey V Zamaraev Source Type: research
Pulmonary fibrosis: from pathogenesis to clinical decision-making
Trends Mol Med. 2023 Sep 14:S1471-4914(23)00195-8. doi: 10.1016/j.molmed.2023.08.010. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) encompasses a spectrum of chronic lung diseases that progressively impact the interstitium, resulting in compromised gas exchange, breathlessness, diminished quality of life (QoL), and ultimately respiratory failure and mortality. Various diseases can cause PF, with their underlying causes primarily affecting the lung interstitium, leading to their referral as interstitial lung diseases (ILDs). The current understanding is that PF arises from abnormal wound healing processes triggered ...
Source: Trends in Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Thomas Koudstaal Manuela Funke-Chambour Michael Kreuter Philip L Molyneaux Marlies S Wijsenbeek Source Type: research
Neuropsychiatric biomarker discovery: go big or go home
Trends Mol Med. 2023 Sep 13:S1471-4914(23)00217-4. doi: 10.1016/j.molmed.2023.09.002. Online ahead of print.ABSTRACTTechnological advances have enabled high-throughput omics assays, such as parallelized screening of lipids across plasma samples. Pioneering a new paradigm for neuropsychiatric biomarker discovery, Yap et al. describe a large-scale systematic analysis of comprehensive phenotypic, genotypic, environmental, and lipidomic data to unravel the intricate interplay between these and autism-associated traits.PMID:37714797 | DOI:10.1016/j.molmed.2023.09.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Alicia Ljungdahl Stephan J Sanders Source Type: research
Neuropsychiatric biomarker discovery: go big or go home
Trends Mol Med. 2023 Sep 13:S1471-4914(23)00217-4. doi: 10.1016/j.molmed.2023.09.002. Online ahead of print.ABSTRACTTechnological advances have enabled high-throughput omics assays, such as parallelized screening of lipids across plasma samples. Pioneering a new paradigm for neuropsychiatric biomarker discovery, Yap et al. describe a large-scale systematic analysis of comprehensive phenotypic, genotypic, environmental, and lipidomic data to unravel the intricate interplay between these and autism-associated traits.PMID:37714797 | DOI:10.1016/j.molmed.2023.09.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Alicia Ljungdahl Stephan J Sanders Source Type: research
Targeting biophysical microenvironment for improved treatment of chronic obstructive pulmonary disease
We present the first comprehensive review of four distinct biophysical hallmarks [i.e., extracellular matrix (ECM) microarchitecture, stiffness, fluid shear stress, and mechanical stretch] in COPD, the possible involvement of pathological changes, possible effects, and correlated in vitro models and sum up the emerging COPD treatments targeting these biophysical hallmarks.PMID:37704492 | DOI:10.1016/j.molmed.2023.08.007 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Han Liu Pengbei Fan Fanli Jin Hui Ren Feng Xu Jiansheng Li Source Type: research
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality
Trends Mol Med. 2023 Sep 11:S1471-4914(23)00189-2. doi: 10.1016/j.molmed.2023.08.004. Online ahead of print.ABSTRACTThe past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable remission. However, 80% of patients do not respond. This review discusses how bacteria are unexpected drivers that reprogram tumor immunity. Manipulating the microbiota impacts on tumor development and reprograms the tumor microenvironment (TME) of mice on imm...
Source: Trends in Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Nicolas Guillot Barnab é Roméo Shima Sepehri Manesh Gerard Milano Patrick Brest Laurence Zitvogel Paul Hofman Baharia Mograbi Source Type: research
