Targeting biophysical microenvironment for improved treatment of chronic obstructive pulmonary disease

We present the first comprehensive review of four distinct biophysical hallmarks [i.e., extracellular matrix (ECM) microarchitecture, stiffness, fluid shear stress, and mechanical stretch] in COPD, the possible involvement of pathological changes, possible effects, and correlated in vitro models and sum up the emerging COPD treatments targeting these biophysical hallmarks.PMID:37704492 | DOI:10.1016/j.molmed.2023.08.007
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Source Type: research