HDL and SARS CoV-2: emerging theragnostic implications
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00026-1. doi: 10.1016/j.molmed.2024.02.001. Online ahead of print.ABSTRACTHigh-density lipoproteins (HDLs) are complex particles with multiple functions. They are thought to have evolved as part of the body's innate defense system against infection. Recent research suggests that HDL levels influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the severity of associated complications, making it a promising target for therapeutic intervention.PMID:38431503 | DOI:10.1016/j.molmed.2024.02.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Alankrita Rani Julia T Stadler Gunther Marsche Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
HDL and SARS CoV-2: emerging theragnostic implications
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00026-1. doi: 10.1016/j.molmed.2024.02.001. Online ahead of print.ABSTRACTHigh-density lipoproteins (HDLs) are complex particles with multiple functions. They are thought to have evolved as part of the body's innate defense system against infection. Recent research suggests that HDL levels influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the severity of associated complications, making it a promising target for therapeutic intervention.PMID:38431503 | DOI:10.1016/j.molmed.2024.02.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Alankrita Rani Julia T Stadler Gunther Marsche Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
HDL and SARS CoV-2: emerging theragnostic implications
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00026-1. doi: 10.1016/j.molmed.2024.02.001. Online ahead of print.ABSTRACTHigh-density lipoproteins (HDLs) are complex particles with multiple functions. They are thought to have evolved as part of the body's innate defense system against infection. Recent research suggests that HDL levels influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the severity of associated complications, making it a promising target for therapeutic intervention.PMID:38431503 | DOI:10.1016/j.molmed.2024.02.001 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Alankrita Rani Julia T Stadler Gunther Marsche Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients
Trends Mol Med. 2024 Feb 25:S1471-4914(24)00007-8. doi: 10.1016/j.molmed.2024.01.007. Online ahead of print.ABSTRACTEarlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote muscle regeneration. Further identification of constitutive HDAC activation in dystrophin-deficient muscles, caused by dysregulated nitric oxide (NO) signaling, provided the rationale for HDACi-based therapeutic interventions for Duchenne muscular dystrophy (DMD). In this rev...
Source: Trends in Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients
Trends Mol Med. 2024 Feb 25:S1471-4914(24)00007-8. doi: 10.1016/j.molmed.2024.01.007. Online ahead of print.ABSTRACTEarlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote muscle regeneration. Further identification of constitutive HDAC activation in dystrophin-deficient muscles, caused by dysregulated nitric oxide (NO) signaling, provided the rationale for HDACi-based therapeutic interventions for Duchenne muscular dystrophy (DMD). In this rev...
Source: Trends in Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients
Trends Mol Med. 2024 Feb 25:S1471-4914(24)00007-8. doi: 10.1016/j.molmed.2024.01.007. Online ahead of print.ABSTRACTEarlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote muscle regeneration. Further identification of constitutive HDAC activation in dystrophin-deficient muscles, caused by dysregulated nitric oxide (NO) signaling, provided the rationale for HDACi-based therapeutic interventions for Duchenne muscular dystrophy (DMD). In this rev...
Source: Trends in Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients
Trends Mol Med. 2024 Feb 25:S1471-4914(24)00007-8. doi: 10.1016/j.molmed.2024.01.007. Online ahead of print.ABSTRACTEarlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote muscle regeneration. Further identification of constitutive HDAC activation in dystrophin-deficient muscles, caused by dysregulated nitric oxide (NO) signaling, provided the rationale for HDACi-based therapeutic interventions for Duchenne muscular dystrophy (DMD). In this rev...
Source: Trends in Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients
Trends Mol Med. 2024 Feb 25:S1471-4914(24)00007-8. doi: 10.1016/j.molmed.2024.01.007. Online ahead of print.ABSTRACTEarlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote muscle regeneration. Further identification of constitutive HDAC activation in dystrophin-deficient muscles, caused by dysregulated nitric oxide (NO) signaling, provided the rationale for HDACi-based therapeutic interventions for Duchenne muscular dystrophy (DMD). In this rev...
Source: Trends in Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
Science around the world
Trends Mol Med. 2024 Feb 23:S1471-4914(24)00008-X. doi: 10.1016/j.molmed.2024.01.008. Online ahead of print.NO ABSTRACTPMID:38402077 | DOI:10.1016/j.molmed.2024.01.008 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 24, 2024 Category: Molecular Biology Authors: Jeremy P Burton Rikke Hahn Kofoed Ruslan Rust Source Type: research
Science around the world
Trends Mol Med. 2024 Feb 23:S1471-4914(24)00008-X. doi: 10.1016/j.molmed.2024.01.008. Online ahead of print.NO ABSTRACTPMID:38402077 | DOI:10.1016/j.molmed.2024.01.008 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 24, 2024 Category: Molecular Biology Authors: Jeremy P Burton Rikke Hahn Kofoed Ruslan Rust Source Type: research
There is nothing as inconsistent as the OSFED diagnostic criteria
Trends Mol Med. 2024 Feb 22:S1471-4914(24)00006-6. doi: 10.1016/j.molmed.2024.01.006. Online ahead of print.ABSTRACTAtypical anorexia nervosa (AAN), purging disorder (PD), night eating syndrome (NES), and subthreshold bulimia nervosa and binge-eating disorder (Sub-BN/BED) are the five categories that comprise the 'Other Specified Feeding or Eating Disorder' (OSFED) category in the Diagnostic and Statistical Manual for Mental Disorders (DSM-5). In this review, we examine problems with the diagnostic criteria that are currently proposed for the five OSFED types. We conclude that the existing diagnostic criteria for OSFED are...
Source: Trends in Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Isabel Krug An Binh Dang Elizabeth K Hughes Source Type: research
There is nothing as inconsistent as the OSFED diagnostic criteria
Trends Mol Med. 2024 Feb 22:S1471-4914(24)00006-6. doi: 10.1016/j.molmed.2024.01.006. Online ahead of print.ABSTRACTAtypical anorexia nervosa (AAN), purging disorder (PD), night eating syndrome (NES), and subthreshold bulimia nervosa and binge-eating disorder (Sub-BN/BED) are the five categories that comprise the 'Other Specified Feeding or Eating Disorder' (OSFED) category in the Diagnostic and Statistical Manual for Mental Disorders (DSM-5). In this review, we examine problems with the diagnostic criteria that are currently proposed for the five OSFED types. We conclude that the existing diagnostic criteria for OSFED are...
Source: Trends in Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Isabel Krug An Binh Dang Elizabeth K Hughes Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
